| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,567,001 | 9,067,001 | +3,500,000 | 0.73 | 1.46 | +0.74 | buy |
| Commodore Capital LP | 0 | 3,250,000 | +3,250,000 | 0.00 | 1.12 | +1.12 | buy |
| Siren, L.L.C. | 1,300,000 | 3,734,866 | +2,434,866 | 0.20 | 0.62 | +0.41 | buy |
| Cormorant Asset Management, LP | 0 | 1,450,000 | +1,450,000 | 0.00 | 0.43 | +0.43 | buy |
| QVT Financial LP | 0 | 1,310,593 | +1,310,593 | 0.00 | 0.62 | +0.62 | buy |
| EcoR1 Capital, LLC | 0 | 1,179,715 | +1,179,715 | 0.00 | 0.30 | +0.30 | buy |
| VR Adviser, LLC | 5,345,115 | 6,434,990 | +1,089,875 | 1.38 | 1.43 | +0.05 | buy |
| Boxer Capital Management, LLC | 50,000 | 900,000 | +850,000 | 0.06 | 0.70 | +0.65 | buy |
| BRAIDWELL LP | 3,180,389 | 3,988,989 | +808,600 | 0.53 | 0.79 | +0.26 | buy |
| STEMPOINT CAPITAL LP | 0 | 753,520 | +753,520 | 0.00 | 0.86 | +0.86 | buy |
| Affinity Asset Advisors, LLC | 1,813,671 | 2,564,303 | +750,632 | 0.68 | 0.89 | +0.21 | buy |
| Saturn V Capital Management LP | 0 | 739,960 | +739,960 | 0.00 | 0.80 | +0.80 | buy |
| Point72 Asset Management, L.P. | 226,833 | 872,662 | +645,829 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 560,651 | +560,651 | 0.00 | 0.39 | +0.39 | buy |
| Vestal Point Capital, LP | 0 | 511,000 | +511,000 | 0.00 | 0.09 | +0.09 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,032,680 | 1,508,063 | +475,383 | 0.00 | 0.01 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 450,000 | +450,000 | 0.00 | 0.58 | +0.58 | buy |
| GREAT POINT PARTNERS LLC | 3,815,930 | 4,215,930 | +400,000 | 6.48 | 6.14 | -0.34 | buy |
| Ikarian Capital, LLC | 802,322 | 1,193,492 | +391,170 | 0.54 | 1.02 | +0.47 | buy |
| Qube Research & Technologies Ltd | 59,869 | 450,311 | +390,442 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 282,207 | +282,207 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 136,523 | +136,523 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 404,479 | 527,691 | +123,212 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 48,661 | 169,833 | +121,172 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 116,686 | +116,686 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 262,283 | 374,506 | +112,223 | 0.04 | 0.05 | +0.02 | buy |
| BlackRock, Inc. | 369,365 | 457,359 | +87,994 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 200 | 84,865 | +84,665 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 77,505 | +77,505 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 75,000 | +75,000 | 0.00 | 0.02 | +0.02 | buy |
| Brevan Howard Capital Management LP | 0 | 72,038 | +72,038 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 562,065 | 630,403 | +68,338 | 0.22 | 0.23 | +0.01 | buy |
| XTX Topco Ltd | 66,453 | 119,712 | +53,259 | 0.01 | 0.01 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 46,062 | +46,062 | 0.00 | 0.05 | +0.05 | buy |
| STATE STREET CORP | 156,363 | 194,963 | +38,600 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 63,084 | 95,355 | +32,271 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 31,096 | +31,096 | 0.00 | 0.00 | +0.00 | buy |
| Brendel Financial Advisors LLC | 0 | 28,052 | +28,052 | 0.00 | 0.08 | +0.08 | buy |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 21,600 | +21,600 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 23,532 | 43,135 | +19,603 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 53,389 | 70,192 | +16,803 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 16,146 | +16,146 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 15,681 | +15,681 | 0.00 | 0.02 | +0.02 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 15,300 | +15,300 | 0.00 | 0.02 | +0.02 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 14,791 | +14,791 | 0.00 | 0.01 | +0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,383 | 33,733 | +12,350 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 33,801 | 44,939 | +11,138 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 303,100 | 313,300 | +10,200 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 5,750 | 13,316 | +7,566 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 7,500 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 100,836 | 104,130 | +3,294 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 26,509 | 26,892 | +383 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 318 | +318 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 529,304 | 529,346 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,750,000 | 2,750,000 | 0 | 0.02 | 0.03 | +0.00 | hold |
| Alberta Investment Management Corp | 133,200 | 133,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 24 | 24 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 702 | 702 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Abel Hall, LLC | 13,190 | 13,189 | -1 | 0.02 | 0.02 | +0.00 | sell |
| SBI Securities Co., Ltd. | 138 | 106 | -32 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 19,577 | 14,901 | -4,676 | 0.09 | 0.08 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 8,280 | 0 | -8,280 | 0.00 | 0.00 | -0.00 | sell |
| RBF Capital, LLC | 68,193 | 58,193 | -10,000 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF MONTREAL /CAN/ | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 18,758 | 7,335 | -11,423 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 36,616 | 24,734 | -11,882 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 31,161 | 18,491 | -12,670 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 4,472,756 | 4,458,851 | -13,905 | 0.00 | 0.00 | +0.00 | sell |
| Lighthouse Investment Partners, LLC | 21,660 | 0 | -21,660 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 877,763 | 852,340 | -25,423 | 0.00 | 0.01 | +0.00 | sell |
| INSIGNEO ADVISORY SERVICES, LLC | 55,650 | 25,650 | -30,000 | 0.02 | 0.01 | -0.01 | sell |
| CITIGROUP INC | 39,759 | 9,409 | -30,350 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 117,995 | 85,348 | -32,647 | 0.01 | 0.01 | -0.00 | sell |
| Quadrature Capital Ltd | 36,572 | 0 | -36,572 | 0.00 | 0.00 | -0.00 | sell |
| OMERS ADMINISTRATION Corp | 67,200 | 29,800 | -37,400 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 46,921 | 0 | -46,921 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 77,700 | 28,063 | -49,637 | 0.01 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 52,040 | 0 | -52,040 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 1,560,000 | 1,507,000 | -53,000 | 0.20 | 0.30 | +0.10 | sell |
| Dauntless Investment Group, LLC | 61,010 | 0 | -61,010 | 1.18 | 0.00 | -1.18 | sell |
| GOLDMAN SACHS GROUP INC | 216,810 | 152,915 | -63,895 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 80,400 | 0 | -80,400 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 412,423 | 318,186 | -94,237 | 0.00 | 0.00 | -0.00 | sell |
| PFIZER INC | 2,970,022 | 2,838,913 | -131,109 | 6.58 | 7.05 | +0.47 | sell |
| 683 Capital Management, LLC | 259,165 | 110,000 | -149,165 | 0.11 | 0.06 | -0.05 | sell |
| Caption Management, LLC | 155,936 | 0 | -155,936 | 0.04 | 0.00 | -0.04 | sell |
| UBS Group AG | 470,540 | 241,027 | -229,513 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 284,097 | 0 | -284,097 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 309,157 | 0 | -309,157 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 657,854 | 278,890 | -378,964 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,509,411 | 872,950 | -636,461 | 0.00 | 0.00 | -0.00 | sell |