| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 4,472,843 | +4,472,843 | 0.00 | 1.61 | +1.61 | buy |
| BlackRock, Inc. | 457,359 | 3,614,695 | +3,157,336 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 739,960 | 2,101,119 | +1,361,159 | 0.80 | 1.78 | +0.98 | buy |
| ADAR1 Capital Management, LLC | 630,403 | 1,759,295 | +1,128,892 | 0.23 | 0.49 | +0.26 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 527,691 | 1,584,209 | +1,056,518 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 194,963 | 1,001,637 | +806,674 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 511,000 | 1,173,956 | +662,956 | 0.09 | 0.16 | +0.08 | buy |
| STEMPOINT CAPITAL LP | 753,520 | 1,368,215 | +614,695 | 0.86 | 1.40 | +0.54 | buy |
| QVT Financial LP | 1,310,593 | 1,895,153 | +584,560 | 0.62 | 0.72 | +0.10 | buy |
| GOLDMAN SACHS GROUP INC | 152,915 | 573,946 | +421,031 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 104,130 | 500,086 | +395,956 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 9,067,001 | 9,443,001 | +376,000 | 1.46 | 1.17 | -0.29 | buy |
| CITADEL ADVISORS LLC | 0 | 300,719 | +300,719 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 28,063 | 231,600 | +203,537 | 0.00 | 0.01 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 174,395 | +174,395 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 31,096 | 174,395 | +143,299 | 0.00 | 0.00 | +0.00 | buy |
| ARMISTICE CAPITAL, LLC | 1,507,000 | 1,636,000 | +129,000 | 0.30 | 0.27 | -0.03 | buy |
| Nuveen, LLC | 0 | 126,204 | +126,204 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 124,365 | +124,365 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 65,888 | +65,888 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 58,648 | +58,648 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 53,776 | +53,776 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,335 | 59,437 | +52,102 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 48,385 | +48,385 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 36,749 | +36,749 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 318,186 | 350,902 | +32,716 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 0 | 32,029 | +32,029 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 31,740 | +31,740 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 28,806 | +28,806 | 0.00 | 0.04 | +0.04 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 27,030 | +27,030 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 70,192 | 96,414 | +26,222 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 1,193,492 | 1,218,492 | +25,000 | 1.02 | 1.18 | +0.16 | buy |
| UBS Group AG | 241,027 | 265,314 | +24,287 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 9,409 | 27,763 | +18,354 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 17,387 | +17,387 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 17,042 | +17,042 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 16,916 | +16,916 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 119,712 | 136,224 | +16,512 | 0.01 | 0.01 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 13,200 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 14,901 | 26,968 | +12,067 | 0.08 | 0.17 | +0.09 | buy |
| DIMENSIONAL FUND ADVISORS LP | 43,135 | 55,129 | +11,994 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,616 | +11,616 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 55 | 9,878 | +9,823 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 313,300 | 321,702 | +8,402 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 33,733 | 40,461 | +6,728 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 5,726 | +5,726 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 5,350 | +5,350 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 374,506 | 379,177 | +4,671 | 0.05 | 0.04 | -0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 3,383 | +3,383 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 812 | +812 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 323 | +323 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 207 | +207 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 1 | 50 | +49 | 0.00 | 0.00 | +0.00 | buy |
| Abel Hall, LLC | 13,189 | 13,229 | +40 | 0.02 | 0.01 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 85,348 | 85,348 | 0 | 0.01 | 0.01 | -0.00 | hold |
| RBF Capital, LLC | 58,193 | 58,193 | 0 | 0.02 | 0.01 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,750,000 | 2,750,000 | 0 | 0.03 | 0.02 | -0.00 | hold |
| GREAT POINT PARTNERS LLC | 4,215,930 | 4,215,930 | 0 | 6.14 | 5.86 | -0.28 | hold |
| Alberta Investment Management Corp | 133,200 | 133,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 1,179,715 | 1,179,715 | 0 | 0.30 | 0.35 | +0.05 | hold |
| VR Adviser, LLC | 6,434,990 | 6,434,990 | 0 | 1.43 | 1.15 | -0.28 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Commodore Capital LP | 3,250,000 | 3,250,000 | 0 | 1.12 | 1.14 | +0.02 | hold |
| Siren, L.L.C. | 3,734,866 | 3,734,866 | 0 | 0.62 | 0.45 | -0.17 | hold |
| Foresite Capital Management VI LLC | 450,000 | 450,000 | 0 | 0.58 | 0.41 | -0.17 | hold |
| Boxer Capital Management, LLC | 900,000 | 900,000 | 0 | 0.70 | 0.40 | -0.30 | hold |
| US BANCORP \DE\ | 318 | 318 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 282,207 | 282,207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 702 | 702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Optiver Holding B.V. | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 106 | 77 | -29 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 529,346 | 528,284 | -1,062 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 24,734 | 23,102 | -1,632 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 4,000 | 0 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| INSIGNEO ADVISORY SERVICES, LLC | 25,650 | 20,650 | -5,000 | 0.01 | 0.00 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 21,600 | 16,000 | -5,600 | 0.01 | 0.01 | -0.00 | sell |
| Rockefeller Capital Management L.P. | 7,500 | 0 | -7,500 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 13,316 | 5,788 | -7,528 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 3,988,989 | 3,980,295 | -8,694 | 0.79 | 0.87 | +0.08 | sell |
| MANGROVE PARTNERS IM, LLC | 14,791 | 0 | -14,791 | 0.01 | 0.00 | -0.01 | sell |
| Catalyst Funds Management Pty Ltd | 15,300 | 0 | -15,300 | 0.02 | 0.00 | -0.02 | sell |
| Diametric Capital, LP | 15,681 | 0 | -15,681 | 0.02 | 0.00 | -0.02 | sell |
| SIMPLEX TRADING, LLC | 18,491 | 2,640 | -15,851 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 16,146 | 0 | -16,146 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 44,939 | 27,164 | -17,775 | 0.00 | 0.00 | -0.00 | sell |
| Ghisallo Capital Management LLC | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 26,892 | 0 | -26,892 | 0.00 | 0.00 | -0.00 | sell |
| Brendel Financial Advisors LLC | 28,052 | 0 | -28,052 | 0.08 | 0.00 | -0.08 | sell |
| OMERS ADMINISTRATION Corp | 29,800 | 0 | -29,800 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 136,523 | 97,033 | -39,490 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 46,062 | 0 | -46,062 | 0.05 | 0.00 | -0.05 | sell |
| BARCLAYS PLC | 169,833 | 105,746 | -64,087 | 0.00 | 0.00 | -0.00 | sell |
| Brevan Howard Capital Management LP | 72,038 | 0 | -72,038 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 75,000 | 0 | -75,000 | 0.02 | 0.00 | -0.02 | sell |
| HRT FINANCIAL LP | 77,505 | 0 | -77,505 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 116,686 | 38,800 | -77,886 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 84,865 | 0 | -84,865 | 0.02 | 0.00 | -0.02 | sell |
| Hudson Bay Capital Management LP | 95,355 | 0 | -95,355 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 4,458,851 | 4,354,715 | -104,136 | 0.00 | 0.00 | -0.00 | sell |