| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAR1 Capital Management, LLC | 0 | 3,770,649 | +3,770,649 | 0.00 | 2.57 | +2.57 | buy |
| BRAIDWELL LP | 0 | 2,472,806 | +2,472,806 | 0.00 | 0.28 | +0.28 | buy |
| STEMPOINT CAPITAL LP | 0 | 1,044,168 | +1,044,168 | 0.00 | 1.27 | +1.27 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 738,718 | +738,718 | 0.00 | 0.49 | +0.49 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 535,080 | 912,625 | +377,545 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 612,389 | 813,443 | +201,054 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 172,853 | 344,411 | +171,558 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 267,759 | 395,059 | +127,300 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 51,737 | 176,973 | +125,236 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 192,835 | 291,807 | +98,972 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 97,374 | +97,374 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 57,858 | +57,858 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 56,866 | +56,866 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 7,304 | 64,061 | +56,757 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 17,400 | 63,900 | +46,500 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 45,455 | +45,455 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 43,858 | +43,858 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 47,109 | 85,872 | +38,763 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 38,335 | +38,335 | 0.00 | 0.06 | +0.06 | buy |
| CITIGROUP INC | 4,357 | 32,098 | +27,741 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 27,260 | +27,260 | 0.00 | 0.00 | +0.00 | buy |
| ANGELO GORDON & CO., L.P. | 0 | 22,500 | +22,500 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 0 | 21,653 | +21,653 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 17,495 | +17,495 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 17,442 | +17,442 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,135 | 24,300 | +16,165 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 15,324 | +15,324 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 15,177 | +15,177 | 0.00 | 0.00 | +0.00 | buy |
| Millington Financial Advisors, LLC | 0 | 14,574 | +14,574 | 0.00 | 0.04 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 13,915 | +13,915 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 13,674 | +13,674 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 10,768 | 23,738 | +12,970 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 11,250 | +11,250 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 16,894 | 27,426 | +10,532 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 73,396 | 80,912 | +7,516 | 0.01 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 626 | 4,497 | +3,871 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,906 | 4,779 | +2,873 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 515,899 | 518,656 | +2,757 | 0.02 | 0.02 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 12,319 | 14,502 | +2,183 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,450 | 3,285 | +1,835 | 0.00 | 0.00 | +0.00 | buy |
| CLEAR STREET LLC | 0 | 1,681 | +1,681 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 986 | +986 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 750 | +750 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 187 | 934 | +747 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,308 | 2,735 | +427 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 6 | 11 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 28,840 | 28,840 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Polar Asset Management Partners Inc. | 259,241 | 259,241 | 0 | 0.02 | 0.03 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,217,503 | 3,217,503 | 0 | 0.15 | 0.15 | +0.00 | hold |
| Hudson Bay Capital Management LP | 38,999 | 38,999 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,860,939 | 4,860,939 | 0 | 0.69 | 0.71 | +0.01 | hold |
| Arax Advisory Partners | 245 | 245 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital Advisors, Ltd. LLC | 138 | 138 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 2,413,127 | 2,413,127 | 0 | 0.03 | 0.03 | +0.01 | hold |
| Affinity Asset Advisors, LLC | 223,335 | 223,335 | 0 | 0.12 | 0.14 | +0.02 | hold |
| Deep Track Capital, LP | 3,283,783 | 3,283,783 | 0 | 0.34 | 0.43 | +0.08 | hold |
| SUPERSTRING CAPITAL MANAGEMENT LP | 156,626 | 156,626 | 0 | 0.69 | 0.57 | -0.12 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 8,547 | 8,547 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 1,500 | 1,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 256 | 256 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 628 | 0 | -628 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 7,221 | 3,154 | -4,067 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 41,569 | 30,810 | -10,759 | 0.07 | 0.06 | -0.01 | sell |
| Mariner, LLC | 11,279 | 0 | -11,279 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 77,416 | 0 | -77,416 | 0.03 | 0.00 | -0.03 | sell |
| CITADEL ADVISORS LLC | 633,663 | 336,828 | -296,835 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 328,504 | 0 | -328,504 | 0.28 | 0.00 | -0.28 | sell |
| ARMISTICE CAPITAL, LLC | 2,524,000 | 1,500,000 | -1,024,000 | 0.23 | 0.16 | -0.07 | sell |
| GREAT POINT PARTNERS LLC | 4,642,241 | 3,263,672 | -1,378,569 | 3.11 | 4.00 | +0.89 | sell |
| VR Adviser, LLC | 6,023,166 | 2,023,166 | -4,000,000 | 1.34 | 0.43 | -0.91 | sell |