| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,860,939 | 5,472,891 | +611,952 | 0.19 | 0.72 | +0.53 | buy |
| VR Adviser, LLC | 4,631,216 | 4,631,216 | 0 | 0.36 | 1.13 | +0.76 | hold |
| JPMORGAN CHASE & CO | 4,659,951 | 4,624,199 | -35,752 | 0.00 | 0.00 | +0.00 | sell |
| GREAT POINT PARTNERS LLC | 3,170,194 | 3,815,930 | +645,736 | 2.16 | 6.90 | +4.73 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 3,045,444 | +3,045,444 | 0.00 | 0.02 | +0.02 | buy |
| PFIZER INC | 2,970,022 | 2,970,022 | 0 | 0.54 | 2.94 | +2.40 | hold |
| BRAIDWELL LP | 2,472,806 | 2,472,806 | 0 | 0.09 | 0.32 | +0.23 | hold |
| Ikarian Capital, LLC | 0 | 2,132,322 | +2,132,322 | 0.00 | 1.87 | +1.87 | buy |
| ARMISTICE CAPITAL, LLC | 1,536,000 | 1,560,000 | +24,000 | 0.06 | 0.21 | +0.15 | buy |
| Affinity Asset Advisors, LLC | 223,335 | 1,274,351 | +1,051,016 | 0.03 | 0.51 | +0.48 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 824,078 | +824,078 | 0.00 | 0.09 | +0.09 | buy |
| Point72 Asset Management, L.P. | 2,350,000 | 726,328 | -1,623,672 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 720,452 | +720,452 | 0.00 | 0.45 | +0.45 | buy |
| ADAR1 Capital Management, LLC | 997,547 | 652,154 | -345,393 | 0.17 | 0.28 | +0.11 | sell |
| MILLENNIUM MANAGEMENT LLC | 789,309 | 589,700 | -199,609 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 569,139 | 531,286 | -37,853 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 517,144 | 517,144 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMERIPRISE FINANCIAL INC | 0 | 500,000 | +500,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 407,236 | 405,304 | -1,932 | 0.00 | 0.00 | +0.00 | sell |
| BlackRock, Inc. | 578,127 | 365,674 | -212,453 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 0 | 305,329 | +305,329 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 276,000 | +276,000 | 0.00 | 0.10 | +0.10 | buy |
| Deep Track Capital, LP | 1,727,562 | 259,014 | -1,468,548 | 0.06 | 0.03 | -0.03 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 204,133 | 255,400 | +51,267 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 247,747 | +247,747 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 107,712 | 211,882 | +104,170 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 144,363 | 144,363 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 244,925 | 136,303 | -108,622 | 0.00 | 0.00 | +0.00 | sell |
| Alberta Investment Management Corp | 133,200 | 133,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA ADVISERS, LP | 100,100 | 119,100 | +19,000 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 117,995 | +117,995 | 0.00 | 0.01 | +0.01 | buy |
| DLD Asset Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 94,161 | 86,437 | -7,724 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 302,691 | 81,723 | -220,968 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 80,528 | +80,528 | 0.00 | 0.00 | +0.00 | buy |
| RBF Capital, LLC | 120,000 | 80,000 | -40,000 | 0.01 | 0.02 | +0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 114,191 | 76,609 | -37,582 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 44,862 | 65,900 | +21,038 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 21,504 | 49,360 | +27,856 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 156,291 | 44,215 | -112,076 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 16,383 | 38,764 | +22,381 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 31,938 | +31,938 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 25,121 | +25,121 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 63,985 | 21,518 | -42,467 | 0.03 | 0.09 | +0.06 | sell |
| Forefront Wealth Partners, LLC | 0 | 21,518 | +21,518 | 0.00 | 0.02 | +0.02 | buy |
| Savant Capital, LLC | 32,409 | 18,990 | -13,419 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 30,553 | 18,422 | -12,131 | 0.01 | 0.01 | +0.01 | sell |
| Abel Hall, LLC | 13,343 | 13,190 | -153 | 0.01 | 0.02 | +0.02 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 15,560 | 10,692 | -4,868 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 0 | 10,369 | +10,369 | 0.00 | 0.02 | +0.02 | buy |
| MAI Capital Management | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SBI Securities Co., Ltd. | 234 | 1,506 | +1,272 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,369 | 1,369 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 1,206 | 1,206 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Steward Partners Investment Advisory, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 6,973 | 838 | -6,135 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 22,029 | 186 | -21,843 | 0.00 | 0.00 | -0.00 | sell |
| True Wealth Design, LLC | 382 | 78 | -304 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 9,179 | 57 | -9,122 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CIBC WORLD MARKET INC. | 15,000 | 0 | -15,000 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 32,195 | 0 | -32,195 | 0.00 | 0.00 | -0.00 | sell |
| Rangeley Capital, LLC | 21,000 | 0 | -21,000 | 0.03 | 0.00 | -0.03 | sell |
| Ground Swell Capital, LLC | 13,308 | 0 | -13,308 | 0.02 | 0.00 | -0.02 | sell |
| Quadrature Capital Ltd | 15,158 | 0 | -15,158 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 107,881 | 0 | -107,881 | 0.00 | 0.00 | -0.00 | sell |
| IEQ CAPITAL, LLC | 13,841 | 0 | -13,841 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 10,201 | 0 | -10,201 | 0.01 | 0.00 | -0.01 | sell |
| Catalyst Funds Management Pty Ltd | 23,300 | 0 | -23,300 | 0.01 | 0.00 | -0.01 | sell |
| Point72 (DIFC) Ltd | 601 | 0 | -601 | 0.00 | 0.00 | -0.00 | sell |
| Jain Global LLC | 48,750 | 0 | -48,750 | 0.00 | 0.00 | -0.00 | sell |
| Clearstead Advisors, LLC | 239 | 0 | -239 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,180 | 0 | -169,180 | 0.00 | 0.00 | -0.00 | sell |