| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 1,509,411 | +1,509,411 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 1,300,000 | +1,300,000 | 0.00 | 0.20 | +0.20 | buy |
| MARSHALL WACE, LLP | 0 | 877,763 | +877,763 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 4,631,216 | 5,345,115 | +713,899 | 1.13 | 1.38 | +0.25 | buy |
| BRAIDWELL LP | 2,472,806 | 3,180,389 | +707,583 | 0.32 | 0.53 | +0.22 | buy |
| Affinity Asset Advisors, LLC | 1,274,351 | 1,813,671 | +539,320 | 0.51 | 0.68 | +0.17 | buy |
| JANE STREET GROUP, LLC | 211,882 | 657,854 | +445,972 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 589,700 | 1,032,680 | +442,980 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 136,303 | 412,423 | +276,120 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 259,165 | +259,165 | 0.00 | 0.11 | +0.11 | buy |
| CITADEL ADVISORS LLC | 80,528 | 309,157 | +228,629 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 305,329 | 470,540 | +165,211 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 155,936 | +155,936 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 81,723 | 216,810 | +135,087 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 5,472,891 | 5,567,001 | +94,110 | 0.72 | 0.73 | +0.01 | buy |
| Jump Financial, LLC | 0 | 77,700 | +77,700 | 0.00 | 0.01 | +0.01 | buy |
| OMERS ADMINISTRATION Corp | 0 | 67,200 | +67,200 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 66,453 | +66,453 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 63,084 | +63,084 | 0.00 | 0.00 | +0.00 | buy |
| Dauntless Investment Group, LLC | 0 | 61,010 | +61,010 | 0.00 | 1.18 | +1.18 | buy |
| INSIGNEO ADVISORY SERVICES, LLC | 0 | 55,650 | +55,650 | 0.00 | 0.02 | +0.02 | buy |
| ALPS ADVISORS INC | 0 | 53,389 | +53,389 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 517,144 | 568,118 | +50,974 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 2 | 48,661 | +48,659 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 255,400 | 303,100 | +47,700 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 46,921 | +46,921 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 57 | 39,759 | +39,702 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 36,572 | +36,572 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 247,747 | 284,097 | +36,350 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 31,161 | +31,161 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 31,938 | 59,869 | +27,931 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 23,532 | +23,532 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 21,660 | +21,660 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 21,383 | +21,383 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 86,437 | 100,836 | +14,399 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 144,363 | 156,363 | +12,000 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 25,121 | 33,801 | +8,680 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 186 | 8,280 | +8,094 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 10,692 | 18,758 | +8,066 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 5,750 | +5,750 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 365,674 | 369,365 | +3,691 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| MAI Capital Management | 4,000 | 4,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 117,995 | 117,995 | 0 | 0.01 | 0.01 | +0.00 | hold |
| GREAT POINT PARTNERS LLC | 3,815,930 | 3,815,930 | 0 | 6.90 | 6.48 | -0.42 | hold |
| Alberta Investment Management Corp | 133,200 | 133,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ARMISTICE CAPITAL, LLC | 1,560,000 | 1,560,000 | 0 | 0.21 | 0.20 | -0.01 | hold |
| Steward Partners Investment Advisory, LLC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 16 | 16 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Abel Hall, LLC | 13,190 | 13,190 | 0 | 0.02 | 0.02 | -0.01 | hold |
| PFIZER INC | 2,970,022 | 2,970,022 | 0 | 2.94 | 6.58 | +3.64 | hold |
| Arax Advisory Partners | 36 | 24 | -12 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 78 | 0 | -78 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,206 | 702 | -504 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 405,304 | 404,479 | -825 | 0.00 | 0.00 | +0.00 | sell |
| CWM, LLC | 838 | 0 | -838 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 1,506 | 138 | -1,368 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 1,369 | 0 | -1,369 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Analytics, LLC | 21,518 | 19,577 | -1,941 | 0.09 | 0.09 | +0.00 | sell |
| FMR LLC | 531,286 | 529,304 | -1,982 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 38,764 | 36,616 | -2,148 | 0.00 | 0.00 | +0.00 | sell |
| Scientech Research LLC | 10,369 | 0 | -10,369 | 0.02 | 0.00 | -0.02 | sell |
| RBF Capital, LLC | 80,000 | 68,193 | -11,807 | 0.02 | 0.02 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 65,900 | 52,040 | -13,860 | 0.00 | 0.00 | -0.00 | sell |
| Savant Capital, LLC | 18,990 | 0 | -18,990 | 0.00 | 0.00 | -0.00 | sell |
| Forefront Wealth Partners, LLC | 21,518 | 0 | -21,518 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA ADVISERS, LP | 119,100 | 80,400 | -38,700 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 44,215 | 0 | -44,215 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 76,609 | 26,509 | -50,100 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 652,154 | 562,065 | -90,089 | 0.28 | 0.22 | -0.06 | sell |
| DLD Asset Management, LP | 100,000 | 0 | -100,000 | 0.06 | 0.00 | -0.06 | sell |
| JPMORGAN CHASE & CO | 4,624,199 | 4,472,756 | -151,443 | 0.00 | 0.00 | +0.00 | sell |
| Deep Track Capital, LP | 259,014 | 0 | -259,014 | 0.03 | 0.00 | -0.03 | sell |
| Atika Capital Management LLC | 276,000 | 0 | -276,000 | 0.10 | 0.00 | -0.10 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 3,045,444 | 2,750,000 | -295,444 | 0.02 | 0.02 | +0.00 | sell |
| Point72 Asset Management, L.P. | 726,328 | 226,833 | -499,495 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 500,000 | 0 | -500,000 | 0.00 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 824,078 | 262,283 | -561,795 | 0.09 | 0.04 | -0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 720,452 | 0 | -720,452 | 0.45 | 0.00 | -0.45 | sell |
| Ikarian Capital, LLC | 2,132,322 | 802,322 | -1,330,000 | 1.87 | 0.54 | -1.32 | sell |