| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 0 | 2,854,000 | +2,854,000 | 0.00 | 1.81 | +1.81 | buy |
| Integral Health Asset Management, LLC | 0 | 2,250,000 | +2,250,000 | 0.00 | 1.16 | +1.16 | buy |
| VR Adviser, LLC | 0 | 1,555,556 | +1,555,556 | 0.00 | 0.39 | +0.39 | buy |
| VANGUARD GROUP INC | 2,459,444 | 2,862,916 | +403,472 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 400,000 | +400,000 | 0.00 | 0.00 | +0.00 | buy |
| Casdin Capital, LLC | 6,381,377 | 6,732,971 | +351,594 | 2.04 | 2.62 | +0.58 | buy |
| MORGAN STANLEY | 0 | 315,889 | +315,889 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,654,751 | 2,910,126 | +255,375 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 5,507,347 | 5,755,050 | +247,703 | 0.28 | 0.38 | +0.10 | buy |
| CITADEL ADVISORS LLC | 2,001,205 | 2,247,516 | +246,311 | 0.01 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 222,222 | +222,222 | 0.00 | 0.06 | +0.06 | buy |
| BARCLAYS PLC | 66,395 | 274,013 | +207,618 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 0 | 200,668 | +200,668 | 0.00 | 0.09 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 193,221 | +193,221 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 190,000 | +190,000 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 127,232 | +127,232 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 122,222 | +122,222 | 0.00 | 0.06 | +0.06 | buy |
| NEOS Investment Management LLC | 62,159 | 183,420 | +121,261 | 0.02 | 0.06 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 928,763 | 1,040,046 | +111,283 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 88,353 | 168,565 | +80,212 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 148,801 | 225,869 | +77,068 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 45,014 | 110,176 | +65,162 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 60,798 | +60,798 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 56,000 | +56,000 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 919,222 | 969,297 | +50,075 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 42,048 | 79,968 | +37,920 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 30,876 | +30,876 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 0 | 25,891 | +25,891 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,122 | 26,612 | +20,490 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 18,267 | +18,267 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 15,251 | +15,251 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 11,315 | +11,315 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 10,765 | +10,765 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 119,532 | 128,120 | +8,588 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 389,682 | 397,661 | +7,979 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 74,485 | 82,112 | +7,627 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 6,802 | 14,109 | +7,307 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 14,429 | 20,371 | +5,942 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 2,776 | +2,776 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 68,486 | 70,719 | +2,233 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,286 | 16,435 | +2,149 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 211,441 | 211,494 | +53 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 900 | 940 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,317 | 3,317 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 193,000 | 193,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 33,180 | 33,180 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DENALI ADVISORS LLC | 43,300 | 43,300 | 0 | 0.04 | 0.07 | +0.02 | hold |
| Jasper Ridge Partners, L.P. | 10,250 | 10,250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| StepStone Group LP | 462,163 | 462,163 | 0 | 0.27 | 0.51 | +0.24 | hold |
| HighPoint Advisor Group LLC | 70,390 | 70,390 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Alphabet Inc. | 915,705 | 915,705 | 0 | 0.14 | 0.19 | +0.05 | hold |
| Integrated Wealth Concepts LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Euclidean Capital LLC | 1,015,705 | 1,015,705 | 0 | 0.37 | 0.68 | +0.31 | hold |
| Column Group LLC | 9,400,290 | 9,400,290 | 0 | 20.12 | 30.62 | +10.50 | hold |
| BAILARD, INC. | 32,900 | 32,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 4,251 | 4,251 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,020 | 7,005 | -15 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 23,091 | 22,894 | -197 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 12,719 | 11,926 | -793 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 5,207 | 3,354 | -1,853 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 3,509 | 979 | -2,530 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 7,646 | 4,671 | -2,975 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,324 | 2,248 | -3,076 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 6,743 | 3,638 | -3,105 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 18,385 | 14,767 | -3,618 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 23,394 | 18,914 | -4,480 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 25,337 | 16,194 | -9,143 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 12,065 | 0 | -12,065 | 0.00 | 0.00 | -0.00 | sell |
| ATTICUS WEALTH MANAGEMENT, LLC | 69,324 | 56,512 | -12,812 | 0.08 | 0.10 | +0.02 | sell |
| Redwood Wealth Management Group, LLC | 16,350 | 0 | -16,350 | 0.06 | 0.00 | -0.06 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 81,255 | 64,563 | -16,692 | 0.04 | 0.05 | +0.01 | sell |
| MARSHALL WACE, LLP | 18,941 | 0 | -18,941 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 28,100 | 0 | -28,100 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 29,856 | 0 | -29,856 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,323 | 54,453 | -29,870 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 145,000 | 114,700 | -30,300 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 102,035 | 71,580 | -30,455 | 0.00 | 0.00 | +0.00 | sell |
| Man Group plc | 38,540 | 0 | -38,540 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 80,509 | 16,199 | -64,310 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 145,495 | 64,888 | -80,607 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 189,881 | 108,345 | -81,536 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 95,567 | 0 | -95,567 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 294,505 | 179,132 | -115,373 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 502,670 | 375,102 | -127,568 | 0.00 | 0.00 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 219,932 | 0 | -219,932 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 470,845 | 224,051 | -246,794 | 0.13 | 0.09 | -0.04 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 482,325 | 64,500 | -417,825 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,544,543 | 3,346,522 | -1,198,021 | 0.00 | 0.00 | +0.00 | sell |