| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 5,755,050 | 7,622,347 | +1,867,297 | 0.38 | 0.31 | -0.07 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 1,000,000 | +600,000 | 0.00 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 2,862,916 | 3,164,266 | +301,350 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,040,046 | 1,229,188 | +189,142 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 190,000 | 357,500 | +167,500 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,346,522 | 3,513,724 | +167,202 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 82,112 | 219,983 | +137,871 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 64,500 | 157,460 | +92,960 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 969,297 | 1,049,392 | +80,095 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 2,250,000 | 2,325,000 | +75,000 | 1.16 | 0.72 | -0.44 | buy |
| ExodusPoint Capital Management, LP | 0 | 74,715 | +74,715 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 64,888 | 120,704 | +55,816 | 0.00 | 0.00 | -0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 52,744 | +52,744 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 56,000 | 101,717 | +45,717 | 0.00 | 0.00 | +0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 30,600 | +30,600 | 0.00 | 0.07 | +0.07 | buy |
| DIMENSIONAL FUND ADVISORS LP | 71,580 | 102,026 | +30,446 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 211,494 | 237,597 | +26,103 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 128,120 | 152,588 | +24,468 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 23,837 | +23,837 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 193,221 | 216,898 | +23,677 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 79,968 | 102,114 | +22,146 | 0.00 | 0.00 | -0.00 | buy |
| LEAVELL INVESTMENT MANAGEMENT, INC. | 0 | 21,844 | +21,844 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 21,749 | +21,749 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 33,180 | 49,570 | +16,390 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 16,227 | +16,227 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 13,720 | +13,720 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,248 | 15,594 | +13,346 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 12,065 | +12,065 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 11,513 | +11,513 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,719 | 78,160 | +7,441 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,199 | 23,199 | +7,000 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,435 | 22,421 | +5,986 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 3,638 | 9,552 | +5,914 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,891 | 31,642 | +5,751 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 14,767 | 19,534 | +4,767 | 0.00 | 0.00 | -0.00 | buy |
| nVerses Capital, LLC | 0 | 3,300 | +3,300 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 30,876 | 32,603 | +1,727 | 0.02 | 0.01 | -0.01 | buy |
| Russell Investments Group, Ltd. | 0 | 1,617 | +1,617 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 940 | 1,912 | +972 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 612 | +612 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 979 | 1,587 | +608 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 1 | 414 | +413 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 4,251 | 4,618 | +367 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 10,765 | 10,979 | +214 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,005 | 7,039 | +34 | 0.00 | 0.00 | -0.00 | buy |
| CWM, LLC | 1 | 21 | +20 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,317 | 3,317 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 222,222 | 222,222 | 0 | 0.06 | 0.04 | -0.02 | hold |
| Jasper Ridge Partners, L.P. | 10,250 | 10,250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| StepStone Group LP | 462,163 | 462,163 | 0 | 0.51 | 0.29 | -0.22 | hold |
| Casdin Capital, LLC | 6,732,971 | 6,732,971 | 0 | 2.62 | 1.59 | -1.03 | hold |
| VR Adviser, LLC | 1,555,556 | 1,555,556 | 0 | 0.39 | 0.31 | -0.08 | hold |
| Alphabet Inc. | 915,705 | 915,705 | 0 | 0.19 | 0.14 | -0.05 | hold |
| Integrated Wealth Concepts LLC | 15,000 | 15,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Euclidean Capital LLC | 1,015,705 | 1,015,705 | 0 | 0.68 | 0.40 | -0.29 | hold |
| Column Group LLC | 9,400,290 | 9,400,290 | 0 | 30.62 | 40.88 | +10.26 | hold |
| BIT Capital GmbH | 200,668 | 200,668 | 0 | 0.09 | 0.06 | -0.04 | hold |
| BAILARD, INC. | 32,900 | 32,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 11 | 0 | -11 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 11,926 | 11,848 | -78 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 274,013 | 273,486 | -527 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,671 | 3,997 | -674 | 0.00 | 0.00 | -0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 64,563 | 63,838 | -725 | 0.05 | 0.03 | -0.02 | sell |
| Catalyst Funds Management Pty Ltd | 733 | 0 | -733 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 108,345 | 107,579 | -766 | 0.00 | 0.00 | -0.00 | sell |
| HighPoint Advisor Group LLC | 70,390 | 68,890 | -1,500 | 0.02 | 0.02 | -0.01 | sell |
| CITIGROUP INC | 14,109 | 12,314 | -1,795 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 2,776 | 0 | -2,776 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 3,354 | 217 | -3,137 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 26,612 | 23,214 | -3,398 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 397,661 | 394,004 | -3,657 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 18,914 | 13,978 | -4,936 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 11,315 | 0 | -11,315 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 54,453 | 43,018 | -11,435 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 15,251 | 0 | -15,251 | 0.02 | 0.00 | -0.02 | sell |
| SG Americas Securities, LLC | 16,194 | 0 | -16,194 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 18,267 | 0 | -18,267 | 0.00 | 0.00 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 20,371 | 0 | -20,371 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 22,894 | 0 | -22,894 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 193,000 | 168,000 | -25,000 | 0.02 | 0.01 | -0.01 | sell |
| ATTICUS WEALTH MANAGEMENT, LLC | 56,512 | 30,563 | -25,949 | 0.10 | 0.03 | -0.07 | sell |
| NEOS Investment Management LLC | 183,420 | 156,074 | -27,346 | 0.06 | 0.02 | -0.04 | sell |
| TWO SIGMA ADVISERS, LP | 114,700 | 80,000 | -34,700 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 224,051 | 182,062 | -41,989 | 0.09 | 0.04 | -0.05 | sell |
| DENALI ADVISORS LLC | 43,300 | 0 | -43,300 | 0.07 | 0.00 | -0.07 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 168,565 | 110,799 | -57,766 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 60,798 | 0 | -60,798 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 375,102 | 280,661 | -94,441 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 225,869 | 125,686 | -100,183 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 2,247,516 | 2,143,073 | -104,443 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 110,176 | 0 | -110,176 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 122,222 | 0 | -122,222 | 0.06 | 0.00 | -0.06 | sell |
| Qube Research & Technologies Ltd | 127,232 | 0 | -127,232 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 179,132 | 11,862 | -167,270 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 2,854,000 | 2,576,200 | -277,800 | 1.81 | 1.32 | -0.50 | sell |
| MORGAN STANLEY | 315,889 | 0 | -315,889 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,910,126 | 1,320,435 | -1,589,691 | 0.00 | 0.00 | -0.00 | sell |