| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Novo Holdings A/S | 328,809 | 880,000 | +551,191 | 0.52 | 1.29 | +0.77 | buy |
| TimesSquare Capital Management, LLC | 0 | 536,829 | +536,829 | 0.00 | 0.17 | +0.17 | buy |
| Verition Fund Management LLC | 24,011 | 440,538 | +416,527 | 0.00 | 0.05 | +0.05 | buy |
| FEDERATED HERMES, INC. | 372,251 | 786,751 | +414,500 | 0.02 | 0.03 | +0.01 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 262,516 | +262,516 | 0.00 | 0.04 | +0.04 | buy |
| CenterBook Partners LP | 0 | 183,795 | +183,795 | 0.00 | 0.22 | +0.22 | buy |
| BlackRock, Inc. | 762,212 | 863,867 | +101,655 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 154,988 | 218,352 | +63,364 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 68,701 | 118,991 | +50,290 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 257,070 | 288,238 | +31,168 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 481,446 | 512,179 | +30,733 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 0 | 24,300 | +24,300 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 296,050 | 319,501 | +23,451 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 16,667 | +16,667 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 914 | 11,458 | +10,544 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 24,274 | 34,542 | +10,268 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 9,103 | +9,103 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 20,561 | 27,303 | +6,742 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,247 | 7,494 | +6,247 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 102,828 | 108,001 | +5,173 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 3,500 | +3,500 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 12,353 | 15,629 | +3,276 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 69,663 | 72,034 | +2,371 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 696,087 | 698,350 | +2,263 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 2,175 | +2,175 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 1,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 415,361 | 416,908 | +1,547 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 230,787 | 231,629 | +842 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 617 | +617 | 0.00 | 0.00 | +0.00 | buy |
| Legacy Advisors, LLC | 0 | 442 | +442 | 0.00 | 0.02 | +0.02 | buy |
| SOROS FUND MANAGEMENT LLC | 25,000 | 25,356 | +356 | 0.01 | 0.01 | -0.00 | buy |
| EMERALD ADVISERS, LLC | 120,805 | 121,142 | +337 | 0.12 | 0.10 | -0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,957 | 7,269 | +312 | 0.00 | 0.00 | -0.00 | buy |
| Costello Asset Management, INC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 146 | +146 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 145 | +145 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 0 | 141 | +141 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,434 | 6,575 | +141 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL INVESTMENT MANAGEMENT, LLC | 0 | 118 | +118 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 0 | 53 | +53 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorNet Financial, Inc | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 48 | +48 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 46 | +46 | 0.00 | 0.00 | +0.00 | buy |
| HUNTINGTON NATIONAL BANK | 0 | 45 | +45 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 112,500 | 112,500 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Ameritas Investment Partners, Inc. | 1,288 | 1,288 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Board of Trustees of The Leland Stanford Junior University | 623,751 | 623,751 | 0 | 1.38 | 1.02 | -0.36 | hold |
| MARSHALL WACE, LLP | 31,215 | 31,215 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 824,582 | 824,582 | 0 | 0.28 | 0.26 | -0.02 | hold |
| EMERALD MUTUAL FUND ADVISERS TRUST | 77,835 | 77,835 | 0 | 0.12 | 0.11 | -0.02 | hold |
| Redmile Group, LLC | 435,239 | 435,239 | 0 | 0.79 | 0.79 | +0.01 | hold |
| RTW INVESTMENTS, LP | 150,000 | 150,000 | 0 | 0.06 | 0.04 | -0.01 | hold |
| MetLife Investment Management, LLC | 7,749 | 7,749 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MCF Advisors LLC | 242 | 242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Yu Fan | 1,222,202 | 1,222,202 | 0 | 59.41 | 24.13 | -35.29 | hold |
| Steward Partners Investment Advisory, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Larson Financial Group LLC | 191 | 191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 1,088,101 | 1,088,101 | 0 | 64.42 | 54.54 | -9.87 | hold |
| TPG GP A, LLC | 3,967,422 | 3,967,422 | 0 | 1.66 | 1.54 | -0.12 | hold |
| Red Tree Management, LLC | 2,205,661 | 2,205,661 | 0 | 37.57 | 45.75 | +8.18 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 135 | 80 | -55 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 6,122 | 6,033 | -89 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 290 | 0 | -290 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 9,742 | 9,316 | -426 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,582 | 96,053 | -529 | 0.00 | 0.00 | -0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 204,760 | 204,129 | -631 | 0.40 | 0.35 | -0.05 | sell |
| Tower Research Capital LLC (TRC) | 1,411 | 509 | -902 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 280,005 | 279,079 | -926 | 0.06 | 0.05 | -0.01 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,667 | 693 | -974 | 0.00 | 0.00 | -0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,797 | 0 | -1,797 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 2,300 | 0 | -2,300 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 19,190 | 16,105 | -3,085 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 5,448 | 0 | -5,448 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 9,728 | 0 | -9,728 | 0.00 | 0.00 | -0.00 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 14,231 | 0 | -14,231 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 35,686 | 19,951 | -15,735 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 16,316 | 0 | -16,316 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 19,256 | 0 | -19,256 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 34,013 | 5,824 | -28,189 | 0.00 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 60,761 | 28,820 | -31,941 | 0.01 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 32,002 | 0 | -32,002 | 0.11 | 0.00 | -0.11 | sell |
| FMR LLC | 4,950,549 | 4,915,291 | -35,258 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 41,900 | 0 | -41,900 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 65,002 | 21,137 | -43,865 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 58,800 | 13,228 | -45,572 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 125,000 | 75,000 | -50,000 | 0.01 | 0.01 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 75,000 | 0 | -75,000 | 0.03 | 0.00 | -0.03 | sell |
| Woodline Partners LP | 100,000 | 0 | -100,000 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 503,695 | 376,899 | -126,796 | 0.01 | 0.01 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 151,441 | 0 | -151,441 | 0.01 | 0.00 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 180,546 | 0 | -180,546 | 0.13 | 0.00 | -0.13 | sell |
| CITADEL ADVISORS LLC | 206,350 | 0 | -206,350 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 210,000 | 0 | -210,000 | 0.16 | 0.00 | -0.16 | sell |