| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 4,915,291 | 4,838,938 | -76,353 | 0.01 | 0.01 | -0.00 | sell |
| TPG GP A, LLC | 3,967,422 | 3,967,422 | 0 | 1.54 | 3.96 | +2.42 | hold |
| Red Tree Management, LLC | 2,205,661 | 2,205,661 | 0 | 45.75 | 56.36 | +10.61 | hold |
| BlackRock, Inc. | 863,867 | 1,519,622 | +655,755 | 0.00 | 0.00 | +0.00 | buy |
| Yu Fan | 1,222,202 | 1,353,166 | +130,964 | 24.13 | 34.63 | +10.50 | buy |
| VANGUARD GROUP INC | 698,350 | 1,326,843 | +628,493 | 0.00 | 0.00 | +0.00 | buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 1,088,101 | 1,088,101 | 0 | 54.54 | 76.17 | +21.62 | hold |
| Novo Holdings A/S | 880,000 | 900,000 | +20,000 | 1.29 | 1.19 | -0.10 | buy |
| TimesSquare Capital Management, LLC | 536,829 | 796,945 | +260,116 | 0.17 | 0.22 | +0.05 | buy |
| FEDERATED HERMES, INC. | 786,751 | 786,751 | 0 | 0.03 | 0.03 | -0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 416,908 | 555,364 | +138,456 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 512,179 | 507,324 | -4,855 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 376,899 | 470,149 | +93,250 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 288,238 | 447,936 | +159,698 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 435,239 | 435,239 | 0 | 0.79 | 0.87 | +0.08 | hold |
| STATE STREET CORP | 218,352 | 384,350 | +165,998 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,824 | 380,003 | +374,179 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 262,516 | 359,187 | +96,671 | 0.04 | 0.05 | +0.01 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 341,659 | +341,659 | 0.00 | 0.19 | +0.19 | buy |
| LORD, ABBETT & CO. LLC | 319,501 | 295,769 | -23,732 | 0.02 | 0.02 | -0.00 | sell |
| NEXT CENTURY GROWTH INVESTORS LLC | 204,129 | 199,082 | -5,047 | 0.35 | 0.29 | -0.06 | sell |
| NORTHERN TRUST CORP | 108,001 | 168,592 | +60,591 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 164,639 | +164,639 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 150,000 | 150,000 | 0 | 0.04 | 0.04 | -0.00 | hold |
| UBS Group AG | 19,951 | 149,437 | +129,486 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 693 | 143,831 | +143,138 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 118,991 | 128,867 | +9,876 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 96,053 | 128,048 | +31,995 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 121,142 | 125,869 | +4,727 | 0.10 | 0.09 | -0.02 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 123,306 | +123,306 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 77,835 | 98,185 | +20,350 | 0.11 | 0.11 | +0.01 | buy |
| Nuveen, LLC | 16,186 | 91,633 | +75,447 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 183,795 | 86,970 | -96,825 | 0.22 | 0.09 | -0.13 | sell |
| DEUTSCHE BANK AG\ | 231,629 | 84,371 | -147,258 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 78,809 | +78,809 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 0 | 76,165 | +76,165 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 72,568 | +72,568 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 66,432 | +66,432 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 34,542 | 59,527 | +24,985 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 27,303 | 57,786 | +30,483 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 56,269 | +56,269 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| SEI INVESTMENTS CO | 0 | 47,089 | +47,089 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 46,533 | +46,533 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 16,105 | 46,410 | +30,305 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 44,208 | +44,208 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 31,215 | 44,143 | +12,928 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 15,629 | 32,806 | +17,177 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,667 | 29,857 | +13,190 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 28,820 | 28,791 | -29 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 24,300 | 24,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 7,269 | 21,651 | +14,382 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 440,538 | 21,284 | -419,254 | 0.05 | 0.00 | -0.05 | sell |
| F/m Investments LLC | 0 | 20,350 | +20,350 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 16,960 | +16,960 | 0.00 | 0.01 | +0.01 | buy |
| Quantbot Technologies LP | 9,103 | 15,504 | +6,401 | 0.01 | 0.01 | +0.00 | buy |
| MetLife Investment Management, LLC | 7,749 | 15,365 | +7,616 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,227 | +14,227 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,575 | 13,079 | +6,504 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,467 | +12,467 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 11,458 | 12,099 | +641 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 11,606 | +11,606 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 10,509 | +10,509 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 21,137 | 10,134 | -11,003 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 9,316 | 10,095 | +779 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,500 | 8,700 | +5,200 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 7,494 | 7,565 | +71 | 0.00 | 0.00 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,175 | 5,677 | +3,502 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,288 | 2,544 | +1,256 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 509 | 2,310 | +1,801 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 1,900 | 1,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Quarry LP | 0 | 957 | +957 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 420 | 420 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 44 | 389 | +345 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 145 | 365 | +220 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 323 | +323 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 313 | +313 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 63 | 265 | +202 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 242 | 242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Costello Asset Management, INC | 200 | 200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GROUP ONE TRADING LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 191 | 191 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 146 | 146 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Washington Trust Advisors, Inc. | 141 | 141 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Steward Partners Investment Advisory, LLC | 80 | 80 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fortitude Family Office, LLC | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 80 | 60 | -20 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorNet Financial, Inc | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 46 | 9 | -37 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 25,356 | 0 | -25,356 | 0.01 | 0.00 | -0.01 | sell |
| ORBIMED ADVISORS LLC | 112,500 | 0 | -112,500 | 0.05 | 0.00 | -0.05 | sell |
| Board of Trustees of The Leland Stanford Junior University | 623,751 | 0 | -623,751 | 1.02 | 0.00 | -1.02 | sell |
| RA CAPITAL MANAGEMENT, L.P. | 824,582 | 0 | -824,582 | 0.26 | 0.00 | -0.26 | sell |
| Alyeska Investment Group, L.P. | 75,000 | 0 | -75,000 | 0.01 | 0.00 | -0.01 | sell |
| SIGNATUREFD, LLC | 48 | 0 | -48 | 0.00 | 0.00 | -0.00 | sell |
| Legacy Advisors, LLC | 442 | 0 | -442 | 0.02 | 0.00 | -0.02 | sell |
| Walleye Capital LLC | 13,228 | 0 | -13,228 | 0.00 | 0.00 | -0.00 | sell |
| BELLEVUE ASSET MANAGEMENT, LLC | 53 | 0 | -53 | 0.00 | 0.00 | -0.00 | sell |