| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 4,950,549 | +4,950,549 | 0.00 | 0.01 | +0.01 | buy |
| TPG GP A, LLC | 0 | 3,967,422 | +3,967,422 | 0.00 | 1.66 | +1.66 | buy |
| Yu Fan | 0 | 1,222,202 | +1,222,202 | 0.00 | 59.41 | +59.41 | buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 0 | 1,088,101 | +1,088,101 | 0.00 | 64.42 | +64.42 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 824,582 | +824,582 | 0.00 | 0.28 | +0.28 | buy |
| BlackRock, Inc. | 0 | 762,212 | +762,212 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 696,087 | +696,087 | 0.00 | 0.00 | +0.00 | buy |
| Board of Trustees of The Leland Stanford Junior University | 0 | 623,751 | +623,751 | 0.00 | 1.38 | +1.38 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 503,695 | +503,695 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 0 | 481,446 | +481,446 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 0 | 435,239 | +435,239 | 0.00 | 0.79 | +0.79 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 415,361 | +415,361 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 372,251 | +372,251 | 0.00 | 0.02 | +0.02 | buy |
| Novo Holdings A/S | 0 | 328,809 | +328,809 | 0.00 | 0.52 | +0.52 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 318,072 | +318,072 | 0.00 | 0.01 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 0 | 296,050 | +296,050 | 0.00 | 0.02 | +0.02 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 280,005 | +280,005 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 257,070 | +257,070 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 230,787 | +230,787 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 210,000 | +210,000 | 0.00 | 0.16 | +0.16 | buy |
| CITADEL ADVISORS LLC | 0 | 206,350 | +206,350 | 0.00 | 0.00 | +0.00 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 0 | 204,760 | +204,760 | 0.00 | 0.40 | +0.40 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 180,546 | +180,546 | 0.00 | 0.13 | +0.13 | buy |
| STATE STREET CORP | 0 | 154,988 | +154,988 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 0 | 151,441 | +151,441 | 0.00 | 0.01 | +0.01 | buy |
| RTW INVESTMENTS, LP | 0 | 150,000 | +150,000 | 0.00 | 0.06 | +0.06 | buy |
| Alyeska Investment Group, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 0 | 120,805 | +120,805 | 0.00 | 0.12 | +0.12 | buy |
| ORBIMED ADVISORS LLC | 0 | 112,500 | +112,500 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 0 | 102,828 | +102,828 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 96,582 | +96,582 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 77,835 | +77,835 | 0.00 | 0.12 | +0.12 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 75,000 | +75,000 | 0.00 | 0.03 | +0.03 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 69,663 | +69,663 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 68,701 | +68,701 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 65,002 | +65,002 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 60,761 | +60,761 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 58,800 | +58,800 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 41,900 | +41,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 35,686 | +35,686 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 34,013 | +34,013 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 32,002 | +32,002 | 0.00 | 0.11 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 31,215 | +31,215 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 0 | 24,274 | +24,274 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 24,011 | +24,011 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 20,561 | +20,561 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 19,256 | +19,256 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 19,190 | +19,190 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 16,316 | +16,316 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 14,231 | +14,231 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 12,353 | +12,353 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 9,742 | +9,742 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 9,728 | +9,728 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 7,749 | +7,749 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,957 | +6,957 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 6,434 | +6,434 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 6,122 | +6,122 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 5,448 | +5,448 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,797 | +1,797 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,667 | +1,667 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,411 | +1,411 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,288 | +1,288 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,247 | +1,247 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 914 | +914 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 420 | +420 | 0.00 | 0.00 | +0.00 | buy |
| CREATIVE FINANCIAL DESIGNS INC /ADV | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| MCF Advisors LLC | 0 | 242 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 191 | +191 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |