| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 57,698 | 1,436,964 | +1,379,266 | 0.83 | 14.36 | +13.53 | buy |
| Paradigm Biocapital Advisors LP | 3,858,008 | 4,177,830 | +319,822 | 13.31 | 11.04 | -2.26 | buy |
| NORGES BANK | 0 | 314,240 | +314,240 | 0.00 | 0.00 | +0.00 | buy |
| Rubric Capital Management LP | 0 | 261,874 | +261,874 | 0.00 | 0.58 | +0.58 | buy |
| FRED ALGER MANAGEMENT, LLC | 321,952 | 544,372 | +222,420 | 0.13 | 0.20 | +0.07 | buy |
| Commodore Capital LP | 1,331,037 | 1,487,756 | +156,719 | 8.56 | 7.47 | -1.09 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 86,707 | 228,115 | +141,408 | 0.01 | 0.02 | +0.01 | buy |
| Rock Springs Capital Management LP | 0 | 125,302 | +125,302 | 0.00 | 0.24 | +0.24 | buy |
| BANK OF MONTREAL /CAN/ | 89,078 | 194,178 | +105,100 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,823 | 98,123 | +73,300 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 3,339,850 | 3,412,072 | +72,222 | 0.01 | 0.01 | -0.00 | buy |
| FMR LLC | 8,725,070 | 8,794,857 | +69,787 | 0.05 | 0.04 | -0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 59,558 | +59,558 | 0.00 | 0.02 | +0.02 | buy |
| Nicholas Investment Partners, LP | 79,200 | 122,790 | +43,590 | 0.68 | 0.94 | +0.26 | buy |
| TWINBEECH CAPITAL LP | 0 | 38,562 | +38,562 | 0.00 | 0.06 | +0.06 | buy |
| Cubist Systematic Strategies, LLC | 0 | 37,491 | +37,491 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 68,856 | 102,431 | +33,575 | 0.01 | 0.01 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 32,192 | +32,192 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,078 | +31,078 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 654,747 | 681,596 | +26,849 | 0.01 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 170,599 | 195,142 | +24,543 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 23,000 | +23,000 | 0.00 | 0.06 | +0.06 | buy |
| J. Goldman & Co LP | 0 | 20,164 | +20,164 | 0.00 | 0.07 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 19,217 | +19,217 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 18,977 | +18,977 | 0.00 | 0.19 | +0.19 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,100 | 33,749 | +18,649 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 175,436 | 194,037 | +18,601 | 0.01 | 0.00 | -0.00 | buy |
| Renaissance Capital LLC | 0 | 17,327 | +17,327 | 0.00 | 0.68 | +0.68 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,832 | 22,147 | +13,315 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 255,897 | 265,897 | +10,000 | 2.70 | 2.99 | +0.28 | buy |
| Engineers Gate Manager LP | 0 | 8,749 | +8,749 | 0.00 | 0.02 | +0.02 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 8,555 | +8,555 | 0.00 | 0.37 | +0.37 | buy |
| Pictet Asset Management Holding SA | 194,004 | 202,356 | +8,352 | 0.02 | 0.02 | +0.00 | buy |
| Jump Financial, LLC | 0 | 7,800 | +7,800 | 0.00 | 0.02 | +0.02 | buy |
| Nebula Research & Development LLC | 8,349 | 15,546 | +7,197 | 0.19 | 0.25 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 6,926 | 13,611 | +6,685 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 6,141 | +6,141 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 54,083 | 60,011 | +5,928 | 1.44 | 1.61 | +0.16 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 5,418 | +5,418 | 0.00 | 0.04 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,881 | 242,044 | +5,163 | 0.00 | 0.00 | -0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,154 | 26,825 | +4,671 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,619 | 11,262 | +4,643 | 0.09 | 0.11 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 4,125 | +4,125 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 280,009 | 284,009 | +4,000 | 0.14 | 0.14 | -0.01 | buy |
| HSBC HOLDINGS PLC | 0 | 3,925 | +3,925 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 7,883 | 11,807 | +3,924 | 0.08 | 0.11 | +0.03 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,178 | 33,042 | +3,864 | 0.03 | 0.03 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 3,522 | +3,522 | 0.00 | 0.06 | +0.06 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 4,346 | 7,781 | +3,435 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 80,631 | 84,018 | +3,387 | 0.00 | 0.00 | -0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 3,354 | +3,354 | 0.00 | 0.01 | +0.01 | buy |
| Kapitalo Investimentos Ltda | 0 | 2,823 | +2,823 | 0.00 | 0.05 | +0.05 | buy |
| NEOS Investment Management LLC | 0 | 2,758 | +2,758 | 0.00 | 0.01 | +0.01 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 2,718 | +2,718 | 0.00 | 0.00 | +0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 0 | 2,687 | +2,687 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,270 | 13,853 | +2,583 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 5,089 | 7,612 | +2,523 | 0.08 | 0.08 | -0.00 | buy |
| LPL Financial LLC | 4,795 | 7,148 | +2,353 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 4,200 | 6,200 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 37,315 | 39,191 | +1,876 | 0.00 | 0.00 | -0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 8,075 | 9,760 | +1,685 | 0.01 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 29,381 | 31,062 | +1,681 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 1,611 | +1,611 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Fund Management Co., Ltd | 0 | 1,495 | +1,495 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 11,700 | 12,900 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF HAWAII | 5,716 | 6,804 | +1,088 | 0.02 | 0.02 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 15,165 | 16,083 | +918 | 0.01 | 0.01 | +0.00 | buy |
| ProShare Advisors LLC | 8,054 | 8,884 | +830 | 0.00 | 0.00 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 501 | +501 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 14,154 | 14,609 | +455 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 2,960 | 3,368 | +408 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 50,500 | 50,900 | +400 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 50 | 299 | +249 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 17,994 | 18,216 | +222 | 0.23 | 0.17 | -0.06 | buy |
| Allspring Global Investments Holdings, LLC | 2,046 | 2,235 | +189 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 10,484 | 10,627 | +143 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 2 | 122 | +120 | 0.00 | 0.01 | +0.01 | buy |
| First Horizon Advisors, Inc. | 158 | 254 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,182 | 28,252 | +70 | 0.00 | 0.00 | -0.00 | buy |
| PRIVATE TRUST CO NA | 16 | 60 | +44 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 71 | 97 | +26 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 315 | 341 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 98 | 106 | +8 | 0.00 | 0.00 | -0.00 | buy |
| JANUS HENDERSON GROUP PLC | 12,843 | 12,850 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Bell Investment Advisors, Inc | 10 | 17 | +7 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 9,774 | 9,780 | +6 | 0.00 | 0.00 | -0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 12 | 13 | +1 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 19,991,024 | 0 | 27.16 | 26.12 | -1.05 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 2,751 | 2,751 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Handelsbanken Fonder AB | 5,400 | 5,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KBC Group NV | 713 | 713 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 17,000 | 17,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mitsubishi UFJ Asset Management Co., Ltd. | 70 | 70 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 14,018 | 14,018 | 0 | 0.01 | 0.01 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 22 | 22 | 0 | 0.00 | 0.00 | -0.00 | hold |