| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Darwin Global Management, Ltd. | 57,698 | 1,436,964 | +1,379,266 | 0.83 | 14.36 | +13.53 | buy |
| Paradigm Biocapital Advisors LP | 3,858,008 | 4,177,830 | +319,822 | 13.31 | 11.04 | -2.26 | buy |
| FRED ALGER MANAGEMENT, LLC | 321,952 | 544,372 | +222,420 | 0.13 | 0.20 | +0.07 | buy |
| Commodore Capital LP | 1,331,037 | 1,487,756 | +156,719 | 8.56 | 7.47 | -1.09 | buy |
| Nicholas Investment Partners, LP | 79,200 | 122,790 | +43,590 | 0.68 | 0.94 | +0.26 | buy |
| D. E. Shaw & Co., Inc. | 468,183 | 445,382 | +22,801 | 0.06 | 0.05 | 0.00 | sell |
| First Turn Management, LLC | 255,897 | 265,897 | +10,000 | 2.70 | 2.99 | +0.28 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 185,121 | 176,245 | +8,876 | 0.01 | 0.01 | -0.00 | sell |
| Nebula Research & Development LLC | 8,349 | 15,546 | +7,197 | 0.19 | 0.25 | +0.07 | buy |
| HighVista Strategies LLC | 54,083 | 60,011 | +5,928 | 1.44 | 1.61 | +0.16 | buy |
| China Universal Asset Management Co., Ltd. | 6,619 | 11,262 | +4,643 | 0.09 | 0.11 | +0.01 | buy |
| Candriam S.C.A. | 280,009 | 284,009 | +4,000 | 0.14 | 0.14 | -0.01 | buy |
| Legato Capital Management LLC | 7,883 | 11,807 | +3,924 | 0.08 | 0.11 | +0.03 | buy |
| PROFUND ADVISORS LLC | 20,695 | 17,039 | +3,656 | 0.07 | 0.05 | 0.00 | sell |
| OMERS ADMINISTRATION Corp | 4,200 | 6,200 | +2,000 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF HAWAII | 5,716 | 6,804 | +1,088 | 0.02 | 0.02 | +0.00 | buy |
| ProShare Advisors LLC | 8,054 | 8,884 | +830 | 0.00 | 0.00 | 0.00 | buy |
| Atom Investors LP | 17,994 | 18,216 | +222 | 0.23 | 0.17 | -0.06 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 98 | 106 | +8 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,172 | 1,096 | -76 | 0.05 | 0.04 | -0.01 | sell |
| E Fund Management Co., Ltd. | 6,798 | 5,136 | -1,662 | 0.03 | 0.02 | -0.01 | sell |
| LORD, ABBETT & CO. LLC | 454,151 | 452,192 | -1,959 | 0.12 | 0.11 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 59,867 | 47,808 | -12,059 | 0.62 | 0.44 | -0.18 | sell |
| Informed Momentum Co LLC | 50,180 | 34,981 | -15,199 | 0.66 | 0.41 | -0.25 | sell |
| Global IMC LLC | 62,656 | 45,292 | -17,364 | 1.11 | 0.79 | -0.33 | sell |
| Rafferty Asset Management, LLC | 127,046 | 108,668 | -18,378 | 0.04 | 0.03 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 175,000 | 150,000 | -25,000 | 2.57 | 1.83 | -0.74 | sell |
| Rhenman & Partners Asset Management AB | 112,929 | 87,500 | -25,429 | 0.83 | 0.62 | -0.21 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 193,000 | 157,750 | -35,250 | 4.38 | 3.32 | -1.06 | sell |
| ArrowMark Colorado Holdings LLC | 199,051 | 140,959 | -58,092 | 0.16 | 0.12 | -0.04 | sell |
| PERCEPTIVE ADVISORS LLC | 2,917,991 | 2,783,454 | -134,537 | 4.79 | 3.66 | -1.14 | sell |
| Ikarian Capital, LLC | 258,142 | 101,601 | -156,541 | 5.20 | 2.08 | -3.12 | sell |
| Deep Track Capital, LP | 450,000 | 274,512 | -175,488 | 1.16 | 0.59 | -0.57 | sell |
| Soleus Capital Management, L.P. | 322,888 | 129,288 | -193,600 | 2.64 | 0.85 | -1.78 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,106,382 | 858,161 | -248,221 | 0.01 | 0.01 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 937,728 | 672,877 | -264,851 | 0.83 | 0.50 | -0.33 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,577,267 | 2,697,267 | -880,000 | 25.23 | 16.28 | -8.96 | sell |