| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 19,991,024 | 0 | 27.16 | 26.12 | -1.05 | hold |
| FMR LLC | 8,725,070 | 8,794,857 | +69,787 | 0.05 | 0.04 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 3,858,008 | 4,177,830 | +319,822 | 13.31 | 11.04 | -2.26 | buy |
| VANGUARD GROUP INC | 3,339,850 | 3,412,072 | +72,222 | 0.01 | 0.01 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,917,991 | 2,783,454 | -134,537 | 4.80 | 3.68 | -1.12 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,577,267 | 2,697,267 | -880,000 | 25.23 | 16.28 | -8.96 | sell |
| Fairmount Funds Management LLC | 1,924,626 | 1,924,626 | 0 | 14.96 | 15.75 | +0.79 | hold |
| STATE STREET CORP | 1,701,234 | 1,514,106 | -187,128 | 0.01 | 0.01 | -0.00 | sell |
| Commodore Capital LP | 1,331,037 | 1,487,756 | +156,719 | 8.56 | 7.47 | -1.09 | buy |
| Darwin Global Management, Ltd. | 57,698 | 1,436,964 | +1,379,266 | 0.83 | 14.36 | +13.53 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,106,382 | 858,161 | -248,221 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 654,747 | 681,596 | +26,849 | 0.01 | 0.00 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 937,728 | 672,877 | -264,851 | 0.83 | 0.50 | -0.33 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,013,402 | 593,602 | -419,800 | 0.01 | 0.01 | -0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 321,952 | 544,372 | +222,420 | 0.13 | 0.20 | +0.07 | buy |
| LORD, ABBETT & CO. LLC | 454,151 | 452,192 | -1,959 | 0.12 | 0.11 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 468,183 | 445,382 | -22,801 | 0.05 | 0.04 | -0.01 | sell |
| NORGES BANK | 0 | 314,240 | +314,240 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 280,009 | 284,009 | +4,000 | 0.14 | 0.14 | -0.01 | buy |
| Deep Track Capital, LP | 450,000 | 274,512 | -175,488 | 1.16 | 0.59 | -0.57 | sell |
| NORTHERN TRUST CORP | 280,571 | 267,165 | -13,406 | 0.00 | 0.00 | -0.00 | sell |
| First Turn Management, LLC | 255,897 | 265,897 | +10,000 | 2.70 | 2.99 | +0.28 | buy |
| Rubric Capital Management LP | 0 | 261,874 | +261,874 | 0.00 | 0.58 | +0.58 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 236,881 | 242,044 | +5,163 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 86,707 | 228,115 | +141,408 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 194,004 | 202,356 | +8,352 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 170,599 | 195,142 | +24,543 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 89,078 | 194,178 | +105,100 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 175,436 | 194,037 | +18,601 | 0.01 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 283,820 | 192,813 | -91,007 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 273,123 | 184,671 | -88,452 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 218,629 | 178,369 | -40,260 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 185,121 | 176,245 | -8,876 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 193,000 | 157,750 | -35,250 | 4.38 | 3.32 | -1.06 | sell |
| Affinity Asset Advisors, LLC | 175,000 | 150,000 | -25,000 | 2.57 | 1.83 | -0.74 | sell |
| ArrowMark Colorado Holdings LLC | 199,051 | 140,959 | -58,092 | 0.16 | 0.12 | -0.04 | sell |
| Soleus Capital Management, L.P. | 322,888 | 129,288 | -193,600 | 2.64 | 0.85 | -1.78 | sell |
| Rock Springs Capital Management LP | 0 | 125,302 | +125,302 | 0.00 | 0.24 | +0.24 | buy |
| Nicholas Investment Partners, LP | 79,200 | 122,790 | +43,590 | 0.68 | 0.94 | +0.26 | buy |
| Bank of New York Mellon Corp | 119,414 | 111,917 | -7,497 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 209,141 | 109,884 | -99,257 | 0.02 | 0.01 | -0.01 | sell |
| Rafferty Asset Management, LLC | 127,046 | 108,668 | -18,378 | 0.04 | 0.03 | -0.01 | sell |
| CITIGROUP INC | 68,856 | 102,431 | +33,575 | 0.01 | 0.01 | +0.00 | buy |
| Ikarian Capital, LLC | 258,142 | 101,601 | -156,541 | 5.20 | 2.08 | -3.12 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 24,823 | 98,123 | +73,300 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 90,596 | 90,261 | -335 | 0.00 | 0.00 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 112,929 | 87,500 | -25,429 | 0.83 | 0.62 | -0.21 | sell |
| UBS Group AG | 80,631 | 84,018 | +3,387 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 65,492 | 65,492 | 0 | 0.05 | 0.05 | -0.01 | hold |
| HighVista Strategies LLC | 54,083 | 60,011 | +5,928 | 1.44 | 1.61 | +0.16 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 59,558 | +59,558 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 50,500 | 50,900 | +400 | 0.00 | 0.00 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 59,867 | 47,808 | -12,059 | 0.62 | 0.44 | -0.18 | sell |
| Squarepoint Ops LLC | 55,410 | 47,528 | -7,882 | 0.02 | 0.01 | -0.00 | sell |
| Global IMC LLC | 62,656 | 45,292 | -17,364 | 1.11 | 0.79 | -0.33 | sell |
| RHUMBLINE ADVISERS | 37,315 | 39,191 | +1,876 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 38,562 | +38,562 | 0.00 | 0.06 | +0.06 | buy |
| Cubist Systematic Strategies, LLC | 0 | 37,491 | +37,491 | 0.00 | 0.03 | +0.03 | buy |
| ALLIANCEBERNSTEIN L.P. | 66,089 | 37,170 | -28,919 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 62,782 | 35,623 | -27,159 | 0.06 | 0.03 | -0.04 | sell |
| Informed Momentum Co LLC | 50,180 | 34,981 | -15,199 | 0.66 | 0.41 | -0.25 | sell |
| JPMORGAN CHASE & CO | 49,345 | 34,885 | -14,460 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 84,724 | 34,142 | -50,582 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 15,100 | 33,749 | +18,649 | 0.00 | 0.01 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 29,178 | 33,042 | +3,864 | 0.03 | 0.03 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 32,192 | +32,192 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 88,105 | 31,450 | -56,655 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,078 | +31,078 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 29,381 | 31,062 | +1,681 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 40,164 | 30,733 | -9,431 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 28,182 | 28,252 | +70 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,271 | 27,300 | -12,971 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 22,154 | 26,825 | +4,671 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 27,201 | 25,917 | -1,284 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,066 | 24,353 | -1,713 | 0.01 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 54,655 | 24,237 | -30,418 | 0.14 | 0.05 | -0.09 | sell |
| READYSTATE ASSET MANAGEMENT LP | 0 | 23,000 | +23,000 | 0.00 | 0.06 | +0.06 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,832 | 22,147 | +13,315 | 0.00 | 0.00 | +0.00 | buy |
| J. Goldman & Co LP | 0 | 20,164 | +20,164 | 0.00 | 0.07 | +0.07 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 19,217 | +19,217 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 18,977 | +18,977 | 0.00 | 0.19 | +0.19 | buy |
| Atom Investors LP | 17,994 | 18,216 | +222 | 0.23 | 0.17 | -0.06 | buy |
| Renaissance Capital LLC | 0 | 17,327 | +17,327 | 0.00 | 0.68 | +0.68 | buy |
| PROFUND ADVISORS LLC | 20,695 | 17,039 | -3,656 | 0.07 | 0.05 | -0.02 | sell |
| DekaBank Deutsche Girozentrale | 17,000 | 17,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIRST TRUST ADVISORS LP | 17,192 | 16,654 | -538 | 0.00 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 15,165 | 16,083 | +918 | 0.01 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 8,349 | 15,546 | +7,197 | 0.19 | 0.25 | +0.07 | buy |
| DEUTSCHE BANK AG\ | 14,154 | 14,609 | +455 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 14,018 | 14,018 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 17,796 | 13,911 | -3,885 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,270 | 13,853 | +2,583 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,926 | 13,611 | +6,685 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,209 | 13,097 | -112 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 11,700 | 12,900 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 54,478 | 12,878 | -41,600 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 12,843 | 12,850 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Legato Capital Management LLC | 7,883 | 11,807 | +3,924 | 0.08 | 0.11 | +0.03 | buy |
| Erste Asset Management GmbH | 11,500 | 11,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 6,619 | 11,262 | +4,643 | 0.09 | 0.11 | +0.01 | buy |