| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 241,235 | 840,945 | +599,710 | 0.56 | 2.10 | +1.54 | buy |
| Vestal Point Capital, LP | 600,000 | 1,075,000 | +475,000 | 2.78 | 5.44 | +2.66 | buy |
| Commodore Capital LP | 1,621,600 | 1,855,000 | +233,400 | 9.30 | 9.69 | +0.39 | buy |
| Affinity Asset Advisors, LLC | 285,000 | 460,000 | +175,000 | 3.49 | 5.11 | +1.62 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,297,910 | 1,450,602 | +152,692 | 0.01 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 104,357 | 214,357 | +110,000 | 0.62 | 1.19 | +0.57 | buy |
| Parkman Healthcare Partners LLC | 23,588 | 109,988 | +86,400 | 0.25 | 0.93 | +0.68 | buy |
| Edgestream Partners, L.P. | 11,724 | 68,101 | +56,377 | 0.04 | 0.16 | +0.12 | buy |
| TWO SIGMA INVESTMENTS, LP | 213,882 | 159,123 | +54,759 | 0.04 | 0.03 | 0.00 | sell |
| STEMPOINT CAPITAL LP | 145,234 | 190,401 | +45,167 | 2.85 | 4.31 | +1.46 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 400,014 | 439,018 | +39,004 | 7.00 | 6.50 | -0.50 | buy |
| Nicholas Investment Partners, LP | 76,427 | 106,719 | +30,292 | 0.53 | 0.78 | +0.25 | buy |
| TD ASSET MANAGEMENT INC | 43,666 | 67,078 | +23,412 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 309,521 | 331,927 | +22,406 | 4.34 | 4.75 | +0.41 | buy |
| NEOS Investment Management LLC | 11,617 | 33,794 | +22,177 | 0.02 | 0.05 | +0.02 | buy |
| TEMA ETFS LLC | 11,617 | 33,794 | +22,177 | 0.38 | 0.72 | +0.34 | buy |
| Aberdeen Group plc | 56,701 | 76,688 | +19,987 | 0.01 | 0.01 | +0.00 | buy |
| Legato Capital Management LLC | 5,451 | 8,871 | +3,420 | 0.06 | 0.08 | +0.03 | buy |
| ProShare Advisors LLC | 13,005 | 10,594 | +2,411 | 0.00 | 0.00 | 0.00 | sell |
| Woodline Partners LP | 1,204,927 | 1,205,531 | +604 | 0.64 | 0.56 | -0.08 | buy |
| E Fund Management Co., Ltd. | 4,213 | 4,785 | +572 | 0.02 | 0.02 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,378 | 1,680 | +302 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 5,240 | 5,308 | +68 | 0.01 | 0.01 | -0.00 | buy |
| Atom Investors LP | 48,948 | 48,935 | -13 | 0.48 | 0.43 | -0.05 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 5,594 | 5,494 | -100 | 0.01 | 0.01 | -0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 4,805 | 4,483 | -322 | 0.07 | 0.05 | -0.02 | sell |
| SAMLYN CAPITAL, LLC | 310,037 | 309,594 | -443 | 0.37 | 0.33 | -0.04 | sell |
| China Universal Asset Management Co., Ltd. | 13,913 | 13,271 | -642 | 0.10 | 0.09 | -0.01 | sell |
| PROFUND ADVISORS LLC | 11,670 | 10,785 | -885 | 0.03 | 0.03 | -0.00 | sell |
| Rock Springs Capital Management LP | 429,994 | 427,532 | -2,462 | 1.28 | 1.73 | +0.45 | sell |
| ArrowMark Colorado Holdings LLC | 295,350 | 291,104 | -4,246 | 0.31 | 0.33 | +0.02 | sell |
| Sandia Investment Management LP | 10,000 | 5,500 | -4,500 | 1.48 | 1.14 | -0.34 | sell |
| Polar Asset Management Partners Inc. | 25,580 | 19,130 | -6,450 | 0.02 | 0.03 | +0.01 | sell |
| Rafferty Asset Management, LLC | 59,276 | 51,192 | -8,084 | 0.02 | 0.02 | -0.00 | sell |
| Nebula Research & Development LLC | 23,718 | 12,684 | -11,034 | 0.22 | 0.08 | -0.13 | sell |
| Candriam S.C.A. | 368,095 | 354,129 | -13,966 | 0.17 | 0.16 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 72,500 | 52,500 | -20,000 | 0.58 | 0.43 | -0.16 | sell |
| Alyeska Investment Group, L.P. | 102,605 | 51,303 | -51,302 | 0.03 | 0.01 | -0.02 | sell |
| Paradigm Biocapital Advisors LP | 5,363,379 | 5,269,433 | -93,946 | 14.61 | 17.20 | +2.59 | sell |
| LORD, ABBETT & CO. LLC | 297,588 | 184,967 | -112,621 | 0.07 | 0.05 | -0.03 | sell |
| Artia Global Partners LP | 204,045 | 90,745 | -113,300 | 6.44 | 1.89 | -4.55 | sell |
| FRED ALGER MANAGEMENT, LLC | 308,057 | 187,902 | -120,155 | 0.11 | 0.08 | -0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 793,416 | 531,210 | -262,206 | 0.51 | 0.36 | -0.15 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 680,000 | 397,000 | -283,000 | 0.09 | 0.05 | -0.04 | sell |
| Fairmount Funds Management LLC | 1,317,664 | 727,563 | -590,101 | 10.25 | 8.00 | -2.25 | sell |
| Boxer Capital Management, LLC | 1,120,192 | 450,000 | -670,192 | 7.47 | 9.60 | +2.13 | sell |
| PERCEPTIVE ADVISORS LLC | 2,619,977 | 1,633,968 | -986,009 | 5.65 | 4.09 | -1.56 | sell |