| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,248,450 | 17,248,450 | 0 | 22.24 | 20.85 | -1.39 | hold |
| FMR LLC | 10,852,884 | 9,274,959 | -1,577,925 | 0.06 | 0.05 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 5,269,433 | 5,324,433 | +55,000 | 14.19 | 11.15 | -3.05 | buy |
| BlackRock, Inc. | 4,805,261 | 4,824,785 | +19,524 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 2,205,251 | 3,088,349 | +883,098 | 0.01 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,880,057 | 2,534,145 | +654,088 | 1.94 | 2.75 | +0.81 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,461,823 | 2,470,491 | +8,668 | 0.04 | 0.05 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,146,938 | 2,056,133 | -90,805 | 0.02 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 1,864,675 | 2,035,831 | +171,156 | 0.01 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,536,859 | 1,831,253 | +294,394 | 0.71 | 0.82 | +0.11 | buy |
| PERCEPTIVE ADVISORS LLC | 1,665,105 | 1,580,505 | -84,600 | 3.07 | 3.20 | +0.13 | sell |
| T. Rowe Price Investment Management, Inc. | 1,319,963 | 1,413,637 | +93,674 | 0.08 | 0.10 | +0.02 | buy |
| Deep Track Capital, LP | 0 | 1,376,324 | +1,376,324 | 0.00 | 2.91 | +2.91 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,238,234 | 1,298,107 | +59,873 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,499,574 | 1,237,779 | -261,795 | 0.07 | 0.06 | -0.01 | sell |
| Bellevue Group AG | 1,037,468 | 1,053,268 | +15,800 | 1.98 | 2.57 | +0.59 | buy |
| Commodore Capital LP | 550,000 | 833,600 | +283,600 | 3.68 | 4.94 | +1.26 | buy |
| ALLIANCEBERNSTEIN L.P. | 785,445 | 784,023 | -1,422 | 0.02 | 0.03 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 643,000 | 748,896 | +105,896 | 0.10 | 0.12 | +0.02 | buy |
| BRAIDWELL LP | 821,406 | 700,429 | -120,977 | 2.64 | 2.39 | -0.25 | sell |
| Woodline Partners LP | 610,459 | 610,459 | 0 | 0.24 | 0.24 | -0.00 | hold |
| AMERIPRISE FINANCIAL INC | 564,298 | 563,768 | -530 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 594,459 | 537,158 | -57,301 | 0.01 | 0.01 | -0.00 | sell |
| Vestal Point Capital, LP | 46,000 | 481,715 | +435,715 | 0.17 | 1.38 | +1.21 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 483,504 | 481,180 | -2,324 | 0.33 | 0.36 | +0.03 | sell |
| Hood River Capital Management LLC | 475,440 | 479,998 | +4,558 | 0.52 | 0.49 | -0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 453,311 | 450,801 | -2,510 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 411,354 | 434,742 | +23,388 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 374,232 | 431,067 | +56,835 | 0.02 | 0.02 | +0.00 | buy |
| NORTHERN TRUST CORP | 410,450 | 429,373 | +18,923 | 0.01 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 355,681 | 410,485 | +54,804 | 0.03 | 0.04 | +0.01 | buy |
| Invesco Ltd. | 439,300 | 408,285 | -31,015 | 0.01 | 0.01 | -0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 270,470 | 395,546 | +125,076 | 0.29 | 0.42 | +0.13 | buy |
| Candriam S.C.A. | 358,013 | 391,306 | +33,293 | 0.18 | 0.21 | +0.03 | buy |
| First Turn Management, LLC | 368,697 | 370,344 | +1,647 | 4.24 | 4.24 | +0.00 | buy |
| UBS Group AG | 399,053 | 363,098 | -35,955 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 311,430 | 354,914 | +43,484 | 4.53 | 4.28 | -0.25 | buy |
| Tri Locum Partners LP | 307,371 | 308,506 | +1,135 | 4.01 | 4.44 | +0.42 | buy |
| Affinity Asset Advisors, LLC | 322,633 | 300,000 | -22,633 | 2.33 | 1.80 | -0.53 | sell |
| BANK OF AMERICA CORP /DE/ | 180,369 | 216,516 | +36,147 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 267,389 | 200,790 | -66,599 | 0.00 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 281,215 | 199,878 | -81,337 | 0.09 | 0.07 | -0.02 | sell |
| ArrowMark Colorado Holdings LLC | 296,029 | 186,850 | -109,179 | 0.66 | 0.51 | -0.15 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 172,527 | 178,438 | +5,911 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 195,156 | 166,773 | -28,383 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 161,599 | 161,509 | -90 | 0.00 | 0.00 | +0.00 | sell |
| Nicholas Investment Partners, LP | 160,483 | 159,721 | -762 | 1.18 | 1.18 | +0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 151,969 | 145,288 | -6,681 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 174,066 | 140,592 | -33,474 | 0.01 | 0.01 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 153,360 | 137,764 | -15,596 | 0.01 | 0.01 | -0.00 | sell |
| Aberdeen Group plc | 165,177 | 123,577 | -41,600 | 0.03 | 0.02 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 124,555 | 122,187 | -2,368 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 107,620 | 109,820 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 61,746 | 104,801 | +43,055 | 0.01 | 0.02 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 54,202 | 102,312 | +48,110 | 0.01 | 0.02 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 102,118 | +102,118 | 0.00 | 0.01 | +0.01 | buy |
| Fisher Asset Management, LLC | 100,706 | 97,518 | -3,188 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 91,195 | 92,502 | +1,307 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 89,000 | +89,000 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 118,712 | 88,078 | -30,634 | 1.14 | 0.94 | -0.20 | sell |
| DEUTSCHE BANK AG\ | 83,039 | 87,746 | +4,707 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 92,021 | 81,867 | -10,154 | 0.04 | 0.04 | +0.00 | sell |
| BNP Paribas Asset Management Holding S.A. | 61,130 | 81,775 | +20,645 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 163,350 | 81,200 | -82,150 | 1.54 | 1.03 | -0.51 | sell |
| Swiss National Bank | 78,900 | 78,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 77,138 | +77,138 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,275 | 71,295 | -6,980 | 0.01 | 0.01 | -0.00 | sell |
| Burkehill Global Management, LP | 70,000 | 70,000 | 0 | 0.46 | 0.36 | -0.11 | hold |
| Neuberger Berman Group LLC | 0 | 64,599 | +64,599 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 63,837 | 63,867 | +30 | 0.01 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 63,720 | +63,720 | 0.00 | 0.06 | +0.06 | buy |
| HighVista Strategies LLC | 73,287 | 56,602 | -16,685 | 1.90 | 1.60 | -0.30 | sell |
| Tidal Investments LLC | 0 | 53,415 | +53,415 | 0.00 | 0.02 | +0.02 | buy |
| TEMA ETFS LLC | 36,458 | 53,415 | +16,957 | 0.28 | 0.37 | +0.08 | buy |
| XTX Topco Ltd | 15,498 | 53,354 | +37,856 | 0.04 | 0.10 | +0.05 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 42,360 | 50,026 | +7,666 | 0.01 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,284 | 49,670 | +11,386 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 22,165 | 47,617 | +25,452 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 46,690 | 46,382 | -308 | 0.01 | 0.01 | +0.00 | sell |
| Rafferty Asset Management, LLC | 45,945 | 45,083 | -862 | 0.02 | 0.02 | +0.00 | sell |
| Granahan Investment Management, LLC | 40,211 | 43,003 | +2,792 | 0.17 | 0.21 | +0.04 | buy |
| Walleye Capital LLC | 7,956 | 41,873 | +33,917 | 0.00 | 0.03 | +0.02 | buy |
| Creative Planning | 29,940 | 38,420 | +8,480 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 35,831 | 36,688 | +857 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 41,651 | 34,482 | -7,169 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,460 | 33,460 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,547 | 32,931 | +384 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 125,328 | 30,844 | -94,484 | 0.01 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 23,160 | 29,540 | +6,380 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 28,480 | +28,480 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,299 | 27,653 | +14,354 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 27,631 | 27,397 | -234 | 0.01 | 0.01 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 25,520 | 26,831 | +1,311 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 62,155 | 26,310 | -35,845 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 0 | 24,258 | +24,258 | 0.00 | 0.01 | +0.01 | buy |
| FIFTH THIRD BANCORP | 0 | 23,621 | +23,621 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 59,594 | 23,594 | -36,000 | 0.78 | 0.35 | -0.43 | sell |
| ROYAL BANK OF CANADA | 1,439 | 23,569 | +22,130 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,197 | 23,268 | -1,929 | 0.01 | 0.01 | -0.00 | sell |
| Legato Capital Management LLC | 21,732 | 21,500 | -232 | 0.19 | 0.20 | +0.01 | sell |