| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,880,057 | 2,534,145 | +654,088 | 1.94 | 2.75 | +0.81 | buy |
| Polar Capital Holdings Plc | 1,536,859 | 1,831,253 | +294,394 | 0.71 | 0.82 | +0.11 | buy |
| Commodore Capital LP | 550,000 | 833,600 | +283,600 | 3.68 | 4.94 | +1.26 | buy |
| T. Rowe Price Investment Management, Inc. | 1,319,963 | 1,413,637 | +93,674 | 0.08 | 0.10 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 5,269,433 | 5,324,433 | +55,000 | 14.19 | 11.15 | -3.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 311,430 | 354,914 | +43,484 | 4.53 | 4.28 | -0.25 | buy |
| Candriam S.C.A. | 358,013 | 391,306 | +33,293 | 0.18 | 0.21 | +0.03 | buy |
| Bellevue Group AG | 1,037,468 | 1,053,268 | +15,800 | 1.98 | 2.57 | +0.59 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 6,359 | 12,744 | +6,385 | 0.00 | 0.01 | +0.01 | buy |
| Hood River Capital Management LLC | 475,440 | 479,998 | +4,558 | 0.52 | 0.49 | -0.03 | buy |
| Granahan Investment Management, LLC | 40,211 | 43,003 | +2,792 | 0.17 | 0.21 | +0.04 | buy |
| Tri Locum Partners LP | 307,371 | 308,506 | +1,135 | 4.01 | 4.44 | +0.42 | buy |
| Shay Capital LLC | 7,500 | 8,275 | +775 | 0.12 | 0.12 | -0.00 | buy |
| E Fund Management Co., Ltd. | 5,401 | 5,812 | +411 | 0.02 | 0.02 | -0.00 | buy |
| J.Safra Asset Management Corp | 55 | 169 | +114 | 0.00 | 0.00 | +0.00 | buy |
| Headlands Technologies LLC | 9,225 | 9,297 | +72 | 0.08 | 0.11 | +0.03 | buy |
| ANTIPODES PARTNERS Ltd | 391 | 275 | -116 | 0.00 | 0.00 | -0.00 | sell |
| Legato Capital Management LLC | 21,732 | 21,500 | -232 | 0.19 | 0.20 | +0.01 | sell |
| Nicholas Investment Partners, LP | 160,483 | 159,721 | -762 | 1.18 | 1.18 | +0.01 | sell |
| Bridgewater Associates, LP | 18,578 | 15,020 | -3,558 | 0.01 | 0.01 | +0.00 | sell |
| HighVista Strategies LLC | 73,287 | 56,602 | -16,685 | 1.90 | 1.60 | -0.30 | sell |
| Affinity Asset Advisors, LLC | 322,633 | 300,000 | -22,633 | 2.33 | 1.80 | -0.53 | sell |
| Parkman Healthcare Partners LLC | 118,712 | 88,078 | -30,634 | 1.14 | 0.94 | -0.20 | sell |
| Ikarian Capital, LLC | 59,594 | 23,594 | -36,000 | 0.78 | 0.35 | -0.43 | sell |
| Aberdeen Group plc | 165,177 | 123,577 | -41,600 | 0.03 | 0.02 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 163,350 | 81,200 | -82,150 | 1.54 | 1.03 | -0.51 | sell |
| PERCEPTIVE ADVISORS LLC | 1,665,105 | 1,580,505 | -84,600 | 3.07 | 3.20 | +0.13 | sell |
| ArrowMark Colorado Holdings LLC | 296,029 | 186,850 | -109,179 | 0.66 | 0.51 | -0.15 | sell |