| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 19,991,024 | 0 | 26.12 | 25.23 | -0.88 | hold |
| FMR LLC | 8,794,857 | 8,868,095 | +73,238 | 0.04 | 0.04 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 4,177,830 | 4,571,678 | +393,848 | 11.04 | 13.27 | +2.23 | buy |
| VANGUARD GROUP INC | 3,412,072 | 3,776,016 | +363,944 | 0.01 | 0.01 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,697,267 | 2,697,267 | 0 | 16.28 | 22.46 | +6.19 | hold |
| PERCEPTIVE ADVISORS LLC | 2,783,454 | 2,549,077 | -234,377 | 3.68 | 4.67 | +0.98 | sell |
| Fairmount Funds Management LLC | 1,924,626 | 1,924,626 | 0 | 15.75 | 16.50 | +0.74 | hold |
| Commodore Capital LP | 1,487,756 | 1,487,756 | 0 | 7.47 | 7.70 | +0.23 | hold |
| STATE STREET CORP | 1,514,106 | 1,326,040 | -188,066 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 65,492 | 886,077 | +820,585 | 0.05 | 0.64 | +0.60 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 681,596 | 782,181 | +100,585 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 858,161 | 754,138 | -104,023 | 0.01 | 0.01 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 672,877 | 696,607 | +23,730 | 0.50 | 0.51 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 593,602 | 611,435 | +17,833 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 544,372 | 578,130 | +33,758 | 0.20 | 0.21 | +0.01 | buy |
| Pictet Asset Management Holding SA | 202,356 | 568,884 | +366,528 | 0.02 | 0.05 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 157,750 | 465,710 | +307,960 | 3.32 | 8.72 | +5.40 | buy |
| D. E. Shaw & Co., Inc. | 445,382 | 399,199 | -46,183 | 0.04 | 0.04 | -0.00 | sell |
| MORGAN STANLEY | 184,671 | 386,657 | +201,986 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 192,813 | 348,089 | +155,276 | 0.00 | 0.01 | +0.00 | buy |
| NORGES BANK | 314,240 | 332,681 | +18,441 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 287,500 | +287,500 | 0.00 | 0.13 | +0.13 | buy |
| GOLDMAN SACHS GROUP INC | 178,369 | 285,383 | +107,014 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 33,749 | 282,662 | +248,913 | 0.01 | 0.05 | +0.04 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 242,044 | 265,291 | +23,247 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 267,165 | 264,710 | -2,455 | 0.00 | 0.00 | -0.00 | sell |
| Candriam S.C.A. | 284,009 | 262,008 | -22,001 | 0.14 | 0.12 | -0.02 | sell |
| Rock Springs Capital Management LP | 125,302 | 255,989 | +130,687 | 0.24 | 0.59 | +0.35 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 59,558 | 253,205 | +193,647 | 0.02 | 0.07 | +0.06 | buy |
| First Turn Management, LLC | 265,897 | 252,276 | -13,621 | 2.99 | 3.11 | +0.13 | sell |
| LORD, ABBETT & CO. LLC | 452,192 | 238,205 | -213,987 | 0.11 | 0.06 | -0.05 | sell |
| SAMLYN CAPITAL, LLC | 0 | 229,325 | +229,325 | 0.00 | 0.30 | +0.30 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 200,000 | +50,000 | 1.83 | 2.39 | +0.56 | buy |
| Logos Global Management LP | 0 | 195,000 | +195,000 | 0.00 | 1.70 | +1.70 | buy |
| FRANKLIN RESOURCES INC | 194,037 | 194,691 | +654 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 228,115 | 189,563 | -38,552 | 0.02 | 0.01 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 176,245 | 172,629 | -3,616 | 0.01 | 0.01 | +0.00 | sell |
| Soleus Capital Management, L.P. | 129,288 | 171,788 | +42,500 | 0.85 | 1.15 | +0.30 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 161,200 | +161,200 | 0.00 | 0.03 | +0.03 | buy |
| Ikarian Capital, LLC | 101,601 | 151,601 | +50,000 | 2.08 | 3.59 | +1.51 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 98,123 | 148,609 | +50,486 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 140,959 | 139,891 | -1,068 | 0.12 | 0.13 | +0.01 | sell |
| Bank of New York Mellon Corp | 111,917 | 137,883 | +25,966 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 122,790 | 125,495 | +2,705 | 0.94 | 0.99 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 119,789 | +119,789 | 0.00 | 0.12 | +0.12 | buy |
| Man Group plc | 0 | 118,496 | +118,496 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 90,261 | 94,244 | +3,983 | 0.00 | 0.00 | -0.00 | buy |
| Aberdeen Group plc | 0 | 87,693 | +87,693 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 6,852 | 84,081 | +77,229 | 0.00 | 0.01 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 87,500 | 82,750 | -4,750 | 0.62 | 0.60 | -0.02 | sell |
| CITIGROUP INC | 102,431 | 82,278 | -20,153 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 194,178 | 77,755 | -116,423 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 47,528 | 77,099 | +29,571 | 0.01 | 0.02 | +0.01 | buy |
| JANE STREET GROUP, LLC | 34,142 | 67,361 | +33,219 | 0.00 | 0.01 | +0.00 | buy |
| Rafferty Asset Management, LLC | 108,668 | 64,692 | -43,976 | 0.03 | 0.02 | -0.01 | sell |
| Opaleye Management Inc. | 0 | 59,300 | +59,300 | 0.00 | 1.03 | +1.03 | buy |
| Atom Investors LP | 18,216 | 59,277 | +41,061 | 0.17 | 0.45 | +0.28 | buy |
| Swiss National Bank | 50,900 | 57,800 | +6,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 84,018 | 53,395 | -30,623 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 39,191 | 46,611 | +7,420 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 19,217 | 44,414 | +25,197 | 0.01 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 47,808 | 42,888 | -4,920 | 0.44 | 0.44 | +0.00 | sell |
| Jump Financial, LLC | 7,800 | 41,863 | +34,063 | 0.02 | 0.06 | +0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 24,237 | 39,496 | +15,259 | 0.05 | 0.09 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,170 | 39,120 | +1,950 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 28,252 | 32,245 | +3,993 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 34,885 | 32,045 | -2,840 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 24,353 | 31,202 | +6,849 | 0.00 | 0.01 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,917 | 28,870 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 26,825 | 28,701 | +1,876 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 60,011 | 28,698 | -31,313 | 1.61 | 0.80 | -0.81 | sell |
| Renaissance Capital LLC | 17,327 | 28,481 | +11,154 | 0.68 | 1.21 | +0.53 | buy |
| SEI INVESTMENTS CO | 31,062 | 28,441 | -2,621 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 30,733 | 27,887 | -2,846 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 31,450 | 27,353 | -4,097 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 27,300 | 22,795 | -4,505 | 0.00 | 0.00 | -0.00 | sell |
| FIRST TRUST ADVISORS LP | 16,654 | 20,286 | +3,632 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,018 | 18,506 | +4,488 | 0.01 | 0.01 | +0.00 | buy |
| Allianz Asset Management GmbH | 12,900 | 18,200 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 17,543 | +17,543 | 0.00 | 0.01 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 17,000 | 17,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOR CAPITAL ADVISORS, INC. | 18,977 | 16,559 | -2,418 | 0.19 | 0.10 | -0.09 | sell |
| WELLS FARGO & COMPANY/MN | 13,611 | 15,762 | +2,151 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 15,695 | +15,695 | 0.00 | 0.06 | +0.06 | buy |
| DEUTSCHE BANK AG\ | 14,609 | 15,238 | +629 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 195,142 | 15,220 | -179,922 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 22,147 | 13,364 | -8,783 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 10,627 | 13,063 | +2,436 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 33,042 | 12,788 | -20,254 | 0.03 | 0.01 | -0.02 | sell |
| JANUS HENDERSON GROUP PLC | 12,850 | 12,716 | -134 | 0.00 | 0.00 | -0.00 | sell |
| Cinctive Capital Management LP | 0 | 12,529 | +12,529 | 0.00 | 0.05 | +0.05 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,132 | +12,132 | 0.00 | 0.06 | +0.06 | buy |
| PROFUND ADVISORS LLC | 17,039 | 12,124 | -4,915 | 0.05 | 0.03 | -0.02 | sell |
| Legato Capital Management LLC | 11,807 | 11,807 | 0 | 0.11 | 0.12 | +0.01 | hold |
| Erste Asset Management GmbH | 11,500 | 11,500 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,640 | 10,375 | +8,735 | 0.00 | 0.01 | +0.01 | buy |
| NEOS Investment Management LLC | 2,758 | 9,817 | +7,059 | 0.01 | 0.03 | +0.02 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 9,813 | +9,813 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 9,472 | 9,472 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arizona State Retirement System | 7,088 | 8,215 | +1,127 | 0.00 | 0.00 | +0.00 | buy |