| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Woodline Partners LP | 65,492 | 886,077 | +820,585 | 0.05 | 0.64 | +0.60 | buy |
| Paradigm Biocapital Advisors LP | 4,177,830 | 4,571,678 | +393,848 | 11.04 | 13.27 | +2.23 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 157,750 | 465,710 | +307,960 | 3.32 | 8.72 | +5.40 | buy |
| Rock Springs Capital Management LP | 125,302 | 255,989 | +130,687 | 0.24 | 0.58 | +0.35 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 200,000 | +50,000 | 1.83 | 2.39 | +0.56 | buy |
| Ikarian Capital, LLC | 101,601 | 151,601 | +50,000 | 2.08 | 3.59 | +1.51 | buy |
| D. E. Shaw & Co., Inc. | 445,382 | 399,199 | +46,183 | 0.05 | 0.05 | 0.00 | sell |
| Soleus Capital Management, L.P. | 129,288 | 171,788 | +42,500 | 0.85 | 1.15 | +0.30 | buy |
| Atom Investors LP | 18,216 | 59,277 | +41,061 | 0.17 | 0.45 | +0.28 | buy |
| FRED ALGER MANAGEMENT, LLC | 544,372 | 578,130 | +33,758 | 0.20 | 0.21 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 19,217 | 44,414 | +25,197 | 0.01 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 672,877 | 696,607 | +23,730 | 0.50 | 0.51 | +0.01 | buy |
| Renaissance Capital LLC | 17,327 | 28,481 | +11,154 | 0.68 | 1.21 | +0.53 | buy |
| NEOS Investment Management LLC | 2,758 | 9,817 | +7,059 | 0.01 | 0.03 | +0.02 | buy |
| PROFUND ADVISORS LLC | 17,039 | 12,124 | +4,915 | 0.05 | 0.03 | 0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 176,245 | 172,629 | +3,616 | 0.01 | 0.01 | +0.00 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 3,354 | 6,104 | +2,750 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 122,790 | 125,495 | +2,705 | 0.94 | 0.99 | +0.04 | buy |
| EntryPoint Capital, LLC | 329 | 2,294 | +1,965 | 0.02 | 0.25 | +0.23 | buy |
| ProShare Advisors LLC | 8,884 | 7,210 | +1,674 | 0.00 | 0.00 | 0.00 | sell |
| BANK OF HAWAII | 6,804 | 6,995 | +191 | 0.02 | 0.02 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 1,096 | 1,146 | +50 | 0.04 | 0.04 | -0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 106 | 76 | -30 | 0.00 | 0.00 | -0.00 | sell |
| ELEVATION POINT WEALTH PARTNERS, LLC | 2,687 | 2,655 | -32 | 0.02 | 0.02 | +0.00 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 3,522 | 3,266 | -256 | 0.06 | 0.05 | -0.01 | sell |
| ArrowMark Colorado Holdings LLC | 140,959 | 139,891 | -1,068 | 0.12 | 0.13 | +0.01 | sell |
| Harvest Fund Management Co., Ltd | 1,495 | 306 | -1,189 | 0.00 | 0.00 | +0.00 | sell |
| E Fund Management Co., Ltd. | 5,136 | 3,929 | -1,207 | 0.02 | 0.02 | -0.01 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 18,977 | 16,559 | -2,418 | 0.19 | 0.10 | -0.09 | sell |
| China Universal Asset Management Co., Ltd. | 11,262 | 6,945 | -4,317 | 0.11 | 0.07 | -0.03 | sell |
| Rhenman & Partners Asset Management AB | 87,500 | 82,750 | -4,750 | 0.62 | 0.60 | -0.02 | sell |
| Parkman Healthcare Partners LLC | 47,808 | 42,888 | -4,920 | 0.44 | 0.44 | +0.00 | sell |
| First Turn Management, LLC | 265,897 | 252,276 | -13,621 | 2.99 | 3.11 | +0.13 | sell |
| J. Goldman & Co LP | 20,164 | 6,456 | -13,708 | 0.05 | 0.01 | -0.03 | sell |
| Candriam S.C.A. | 284,009 | 262,008 | -22,001 | 0.14 | 0.12 | -0.02 | sell |
| HighVista Strategies LLC | 60,011 | 28,698 | -31,313 | 1.61 | 0.80 | -0.81 | sell |
| Rafferty Asset Management, LLC | 108,668 | 64,692 | -43,976 | 0.03 | 0.02 | -0.01 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 858,161 | 754,138 | -104,023 | 0.01 | 0.01 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 452,192 | 238,205 | -213,987 | 0.11 | 0.06 | -0.05 | sell |
| PERCEPTIVE ADVISORS LLC | 2,783,454 | 2,549,077 | -234,377 | 3.66 | 4.66 | +1.00 | sell |