| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,991,024 | 17,991,024 | 0 | 25.29 | 24.91 | -0.38 | hold |
| FMR LLC | 9,937,193 | 9,968,846 | +31,653 | 0.04 | 0.04 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,269,433 | 5,269,433 | 0 | 17.20 | 17.17 | -0.04 | hold |
| VANGUARD GROUP INC | 4,439,838 | 4,524,124 | +84,286 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 3,748,361 | 4,046,256 | +297,895 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,450,602 | 1,795,373 | +344,771 | 0.01 | 0.02 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,310,196 | 1,782,581 | +472,385 | 0.05 | 0.07 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,442,384 | 1,576,374 | +133,990 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 1,430,659 | 1,490,279 | +59,620 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,447,267 | 1,447,267 | 0 | 15.19 | 13.82 | -1.37 | hold |
| PERCEPTIVE ADVISORS LLC | 1,633,968 | 1,375,180 | -258,788 | 4.11 | 3.94 | -0.17 | sell |
| Commodore Capital LP | 1,855,000 | 1,375,000 | -480,000 | 9.69 | 7.41 | -2.29 | sell |
| JPMORGAN CHASE & CO | 101,991 | 1,197,187 | +1,095,196 | 0.00 | 0.01 | +0.01 | buy |
| BRAIDWELL LP | 840,945 | 1,175,876 | +334,931 | 2.10 | 3.07 | +0.97 | buy |
| T. Rowe Price Investment Management, Inc. | 450,774 | 1,094,568 | +643,794 | 0.02 | 0.05 | +0.03 | buy |
| Vestal Point Capital, LP | 1,075,000 | 1,075,000 | 0 | 5.44 | 4.32 | -1.13 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 893,456 | 996,845 | +103,389 | 0.00 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 1,205,531 | 904,232 | -301,299 | 0.56 | 0.36 | -0.19 | sell |
| Polar Capital Holdings Plc | 946,723 | 816,087 | -130,636 | 0.41 | 0.33 | -0.08 | sell |
| Fairmount Funds Management LLC | 727,563 | 727,563 | 0 | 8.00 | 7.19 | -0.81 | hold |
| Pictet Asset Management Holding SA | 554,141 | 589,832 | +35,691 | 0.04 | 0.05 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 397,000 | 577,500 | +180,500 | 0.05 | 0.07 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 453,620 | 535,445 | +81,825 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 280,341 | 484,343 | +204,002 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 348,080 | 422,722 | +74,642 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 460,000 | 415,000 | -45,000 | 5.11 | 4.68 | -0.43 | sell |
| AMERICAN CENTURY COMPANIES INC | 282,046 | 374,698 | +92,652 | 0.01 | 0.02 | +0.00 | buy |
| NORGES BANK | 131,618 | 374,597 | +242,979 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 291,104 | 369,858 | +78,754 | 0.33 | 0.51 | +0.17 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 317,764 | 346,506 | +28,742 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 328,331 | 341,774 | +13,443 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 331,927 | 320,798 | -11,129 | 4.75 | 4.57 | -0.18 | sell |
| Candriam S.C.A. | 354,129 | 301,259 | -52,870 | 0.16 | 0.13 | -0.02 | sell |
| BANK OF AMERICA CORP /DE/ | 220,016 | 257,940 | +37,924 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 439,018 | 235,583 | -203,435 | 6.50 | 3.68 | -2.83 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 531,210 | 216,422 | -314,788 | 0.36 | 0.13 | -0.23 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 149,941 | 169,539 | +19,598 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 159,630 | 159,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 130,961 | 156,788 | +25,827 | 0.01 | 0.01 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 0.06 | 0.05 | -0.01 | hold |
| BARCLAYS PLC | 96,037 | 149,606 | +53,569 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 143,937 | +143,937 | 0.00 | 0.11 | +0.11 | buy |
| Bank of New York Mellon Corp | 114,826 | 143,375 | +28,549 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 236,894 | 139,193 | -97,701 | 0.01 | 0.01 | -0.01 | sell |
| RAYMOND JAMES FINANCIAL INC | 133,094 | 138,969 | +5,875 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 109,479 | 136,744 | +27,265 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 58,779 | 135,613 | +76,834 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 214,357 | 125,000 | -89,357 | 1.19 | 0.66 | -0.53 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 120,311 | 123,219 | +2,908 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 109,988 | 119,623 | +9,635 | 0.93 | 1.06 | +0.13 | buy |
| Fisher Asset Management, LLC | 121,338 | 114,761 | -6,577 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 106,719 | 103,722 | -2,997 | 0.78 | 0.70 | -0.07 | sell |
| TD ASSET MANAGEMENT INC | 67,078 | 98,900 | +31,822 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 128,416 | 94,840 | -33,576 | 0.02 | 0.01 | -0.01 | sell |
| Rock Springs Capital Management LP | 427,532 | 93,328 | -334,204 | 1.73 | 0.44 | -1.29 | sell |
| Nuveen, LLC | 83,976 | 92,773 | +8,797 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 187,902 | 91,439 | -96,463 | 0.08 | 0.03 | -0.04 | sell |
| Russell Investments Group, Ltd. | 110,356 | 81,609 | -28,747 | 0.01 | 0.01 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 247,046 | 79,381 | -167,665 | 0.06 | 0.02 | -0.04 | sell |
| Aberdeen Group plc | 76,688 | 76,688 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Tri Locum Partners LP | 95,825 | 75,973 | -19,852 | 3.49 | 1.76 | -1.73 | sell |
| Swiss National Bank | 69,900 | 75,800 | +5,900 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 184,801 | 75,348 | -109,453 | 0.09 | 0.04 | -0.04 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,956 | 72,692 | +23,736 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 59,449 | 66,195 | +6,746 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 53,026 | 66,029 | +13,003 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 37,400 | 63,840 | +26,440 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 421,513 | 61,486 | -360,027 | 0.04 | 0.01 | -0.03 | sell |
| STEMPOINT CAPITAL LP | 190,401 | 59,828 | -130,573 | 4.31 | 1.47 | -2.84 | sell |
| Man Group plc | 75,156 | 54,732 | -20,424 | 0.02 | 0.01 | -0.01 | sell |
| Rhenman & Partners Asset Management AB | 52,500 | 52,500 | 0 | 0.43 | 0.51 | +0.08 | hold |
| HighVista Strategies LLC | 39,876 | 50,460 | +10,584 | 1.09 | 1.41 | +0.33 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.20 | 0.19 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 51,303 | 50,000 | -1,303 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 39,620 | 49,940 | +10,320 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 51,192 | 48,383 | -2,809 | 0.02 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 41,306 | 44,837 | +3,531 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 21,457 | 42,975 | +21,518 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 2,046 | 40,355 | +38,309 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,844 | 40,183 | +7,339 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 65,674 | 38,038 | -27,636 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 35,782 | +35,782 | 0.00 | 0.02 | +0.02 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,822 | 34,000 | +3,178 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 9,874 | 33,714 | +23,840 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 26,527 | 33,347 | +6,820 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 33,794 | 31,762 | -2,032 | 0.05 | 0.03 | -0.02 | sell |
| TEMA ETFS LLC | 33,794 | 31,762 | -2,032 | 0.72 | 0.64 | -0.07 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 45,255 | 30,567 | -14,688 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 27,563 | 29,966 | +2,403 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 28,700 | 29,200 | +500 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 40,674 | 27,556 | -13,118 | 0.01 | 0.01 | -0.00 | sell |
| Aquatic Capital Management LLC | 34,576 | 27,545 | -7,031 | 0.06 | 0.04 | -0.02 | sell |
| State of New Jersey Common Pension Fund D | 24,792 | 25,720 | +928 | 0.01 | 0.01 | -0.00 | buy |
| MetLife Investment Management, LLC | 20,763 | 25,706 | +4,943 | 0.01 | 0.01 | +0.00 | buy |
| Atom Investors LP | 48,935 | 24,160 | -24,775 | 0.43 | 0.16 | -0.26 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,936 | 23,736 | +2,800 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 23,588 | +23,588 | 0.00 | 0.07 | +0.07 | buy |
| NATIXIS | 0 | 22,920 | +22,920 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 19,262 | 22,886 | +3,624 | 0.01 | 0.02 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 24,284 | 22,362 | -1,922 | 0.00 | 0.00 | -0.00 | sell |