| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 450,774 | 1,094,568 | +643,794 | 0.02 | 0.05 | +0.03 | buy |
| JANUS HENDERSON GROUP PLC | 1,310,196 | 1,782,581 | +472,385 | 0.05 | 0.07 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,450,602 | 1,795,373 | +344,771 | 0.01 | 0.02 | +0.00 | buy |
| BRAIDWELL LP | 840,945 | 1,175,876 | +334,931 | 2.10 | 3.07 | +0.97 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 397,000 | 577,500 | +180,500 | 0.05 | 0.07 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 291,104 | 369,858 | +78,754 | 0.33 | 0.51 | +0.17 | buy |
| TD ASSET MANAGEMENT INC | 67,078 | 98,900 | +31,822 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 39,876 | 50,460 | +10,584 | 1.09 | 1.41 | +0.33 | buy |
| Parkman Healthcare Partners LLC | 109,988 | 119,623 | +9,635 | 0.93 | 1.06 | +0.13 | buy |
| ProShare Advisors LLC | 10,594 | 11,291 | +697 | 0.00 | 0.00 | 0.00 | buy |
| E Fund Management Co., Ltd. | 4,785 | 5,401 | +616 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 5,308 | 5,504 | +196 | 0.01 | 0.01 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 13,271 | 13,331 | +60 | 0.09 | 0.10 | +0.01 | buy |
| J.Safra Asset Management Corp | 7 | 9 | +2 | 0.00 | 0.00 | +0.00 | buy |
| ANTIPODES PARTNERS Ltd | 540 | 479 | -61 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 10,785 | 10,408 | -377 | 0.03 | 0.03 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 1,890 | 1,207 | -683 | 0.04 | 0.03 | -0.01 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 5,494 | 4,206 | -1,288 | 0.01 | 0.01 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 51,303 | 50,000 | -1,303 | 0.01 | 0.01 | -0.00 | sell |
| NEOS Investment Management LLC | 33,794 | 31,762 | -2,032 | 0.05 | 0.03 | -0.02 | sell |
| TEMA ETFS LLC | 33,794 | 31,762 | -2,032 | 0.72 | 0.64 | -0.07 | sell |
| CIBC WORLD MARKETS CORP | 7,798 | 5,295 | -2,503 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 51,192 | 48,383 | -2,809 | 0.02 | 0.01 | -0.00 | sell |
| Nicholas Investment Partners, LP | 106,719 | 103,722 | -2,997 | 0.78 | 0.70 | -0.07 | sell |
| Polar Asset Management Partners Inc. | 19,130 | 15,780 | -3,350 | 0.03 | 0.02 | -0.01 | sell |
| Nebula Research & Development LLC | 12,684 | 7,613 | -5,071 | 0.08 | 0.05 | -0.03 | sell |
| Fisher Asset Management, LLC | 121,338 | 114,761 | -6,577 | 0.00 | 0.00 | -0.00 | sell |
| First Turn Management, LLC | 331,927 | 320,798 | -11,129 | 4.75 | 4.57 | -0.18 | sell |
| Voleon Capital Management LP | 20,994 | 6,000 | -14,994 | 0.12 | 0.03 | -0.09 | sell |
| Tri Locum Partners LP | 95,825 | 75,973 | -19,852 | 3.49 | 1.76 | -1.73 | sell |
| Atom Investors LP | 48,935 | 24,160 | -24,775 | 0.43 | 0.16 | -0.26 | sell |
| Affinity Asset Advisors, LLC | 460,000 | 415,000 | -45,000 | 5.11 | 4.68 | -0.43 | sell |
| Candriam S.C.A. | 354,129 | 301,259 | -52,870 | 0.16 | 0.13 | -0.02 | sell |
| Soleus Capital Management, L.P. | 214,357 | 125,000 | -89,357 | 1.19 | 0.66 | -0.53 | sell |
| FRED ALGER MANAGEMENT, LLC | 187,902 | 91,439 | -96,463 | 0.08 | 0.03 | -0.04 | sell |
| STEMPOINT CAPITAL LP | 190,401 | 59,828 | -130,573 | 4.31 | 1.47 | -2.84 | sell |
| Polar Capital Holdings Plc | 946,723 | 816,087 | -130,636 | 0.41 | 0.33 | -0.08 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 439,018 | 235,583 | -203,435 | 6.50 | 3.68 | -2.83 | sell |
| PERCEPTIVE ADVISORS LLC | 1,633,968 | 1,375,180 | -258,788 | 4.09 | 3.89 | -0.20 | sell |
| Woodline Partners LP | 1,205,531 | 904,232 | -301,299 | 0.56 | 0.36 | -0.19 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 531,210 | 216,422 | -314,788 | 0.36 | 0.13 | -0.23 | sell |
| Rock Springs Capital Management LP | 427,532 | 93,328 | -334,204 | 1.73 | 0.44 | -1.29 | sell |
| Commodore Capital LP | 1,855,000 | 1,375,000 | -480,000 | 9.69 | 7.41 | -2.29 | sell |