| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,248,450 | 17,248,450 | 0 | 20.85 | 22.22 | +1.37 | hold |
| Paradigm Biocapital Advisors LP | 5,324,433 | 5,924,433 | +600,000 | 11.15 | 13.70 | +2.55 | buy |
| BlackRock, Inc. | 4,824,785 | 5,585,619 | +760,834 | 0.01 | 0.01 | +0.00 | buy |
| HBK INVESTMENTS L P | 0 | 3,483,100 | +3,483,100 | 0.00 | 5.04 | +5.04 | buy |
| FIL Ltd | 65 | 2,946,506 | +2,946,441 | 0.00 | 0.26 | +0.26 | buy |
| STATE STREET CORP | 2,035,831 | 2,091,044 | +55,213 | 0.01 | 0.01 | +0.00 | buy |
| Deep Track Capital, LP | 1,376,324 | 1,783,322 | +406,998 | 2.91 | 3.24 | +0.33 | buy |
| GLAZER CAPITAL, LLC | 0 | 1,769,665 | +1,769,665 | 0.00 | 5.39 | +5.39 | buy |
| GOLDMAN SACHS GROUP INC | 537,158 | 1,640,833 | +1,103,675 | 0.01 | 0.02 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 1,580,505 | 1,580,505 | 0 | 3.20 | 3.03 | -0.17 | hold |
| FMR LLC | 9,274,959 | 1,417,590 | -7,857,369 | 0.05 | 0.01 | -0.04 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,298,107 | 1,407,353 | +109,246 | 0.01 | 0.01 | +0.00 | buy |
| BARCLAYS PLC | 30,844 | 1,268,265 | +1,237,421 | 0.00 | 0.05 | +0.05 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 2,534,145 | 1,246,456 | -1,287,689 | 2.75 | 1.34 | -1.41 | sell |
| Pentwater Capital Management LP | 0 | 1,175,000 | +1,175,000 | 0.00 | 1.16 | +1.16 | buy |
| Bellevue Group AG | 1,053,268 | 1,053,268 | 0 | 2.57 | 2.74 | +0.17 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 1,037,583 | +1,037,583 | 0.00 | 0.23 | +0.23 | buy |
| BANK OF AMERICA CORP /DE/ | 216,516 | 876,830 | +660,314 | 0.00 | 0.01 | +0.01 | buy |
| First Trust Capital Management L.P. | 0 | 836,918 | +836,918 | 0.00 | 6.02 | +6.02 | buy |
| MORGAN STANLEY | 200,790 | 681,225 | +480,435 | 0.00 | 0.00 | +0.00 | buy |
| NEXPOINT ASSET MANAGEMENT, L.P. | 0 | 617,820 | +617,820 | 0.00 | 5.10 | +5.10 | buy |
| AQR Arbitrage LLC | 0 | 601,633 | +601,633 | 0.00 | 1.06 | +1.06 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 585,583 | +585,583 | 0.00 | 0.24 | +0.24 | buy |
| NORGES BANK | 0 | 560,041 | +560,041 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 429,373 | 508,124 | +78,751 | 0.01 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 470,221 | +470,221 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 450,801 | 470,221 | +19,420 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 18,057 | 404,192 | +386,135 | 0.00 | 0.03 | +0.03 | buy |
| Allianz Asset Management GmbH | 6,700 | 352,500 | +345,800 | 0.00 | 0.04 | +0.04 | buy |
| Absolute Gestao de Investimentos Ltda. | 0 | 350,000 | +350,000 | 0.00 | 11.92 | +11.92 | buy |
| JPMORGAN CHASE & CO | 3,088,349 | 327,692 | -2,760,657 | 0.02 | 0.00 | -0.02 | sell |
| Polar Asset Management Partners Inc. | 0 | 320,529 | +320,529 | 0.00 | 0.72 | +0.72 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 300,017 | +300,017 | 0.00 | 0.49 | +0.49 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 89,000 | 280,900 | +191,900 | 0.01 | 0.05 | +0.03 | buy |
| WHITEBOX ADVISORS LLC | 0 | 275,001 | +275,001 | 0.00 | 0.55 | +0.55 | buy |
| Affinity Asset Advisors, LLC | 300,000 | 275,000 | -25,000 | 1.80 | 1.66 | -0.14 | sell |
| Cinctive Capital Management LP | 0 | 240,806 | +240,806 | 0.00 | 1.19 | +1.19 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 227,386 | +227,386 | 0.00 | 1.30 | +1.30 | buy |
| OMERS ADMINISTRATION Corp | 0 | 225,500 | +225,500 | 0.00 | 0.17 | +0.17 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,470,491 | 217,213 | -2,253,278 | 0.05 | 0.00 | -0.04 | sell |
| Slotnik Capital, LLC | 0 | 210,000 | +210,000 | 0.00 | 7.22 | +7.22 | buy |
| TWO SIGMA INVESTMENTS, LP | 102,118 | 208,978 | +106,860 | 0.01 | 0.02 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 4,150 | 206,068 | +201,918 | 0.00 | 0.11 | +0.10 | buy |
| Sagefield Capital LP | 0 | 196,481 | +196,481 | 0.00 | 1.80 | +1.80 | buy |
| Bank of New York Mellon Corp | 161,509 | 192,209 | +30,700 | 0.00 | 0.00 | +0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 164,398 | +164,398 | 0.00 | 0.03 | +0.03 | buy |
| TORONTO DOMINION BANK | 0 | 153,900 | +153,900 | 0.00 | 0.03 | +0.03 | buy |
| MARSHALL WACE, LLP | 3,194 | 152,122 | +148,928 | 0.00 | 0.02 | +0.02 | buy |
| Maven Securities LTD | 0 | 150,000 | +150,000 | 0.00 | 1.28 | +1.28 | buy |
| Qube Research & Technologies Ltd | 0 | 147,330 | +147,330 | 0.00 | 0.02 | +0.02 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 0 | 145,000 | +145,000 | 0.00 | 0.17 | +0.17 | buy |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 129,300 | +129,300 | 0.00 | 1.00 | +1.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 126,303 | +126,303 | 0.00 | 0.11 | +0.11 | buy |
| Magnetar Financial LLC | 0 | 125,341 | +125,341 | 0.00 | 0.14 | +0.14 | buy |
| Squarepoint Ops LLC | 104,801 | 120,415 | +15,614 | 0.02 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 109,820 | 120,199 | +10,379 | 0.00 | 0.00 | +0.00 | buy |
| Chicago Capital Management, LLC | 0 | 115,500 | +115,500 | 0.00 | 9.84 | +9.84 | buy |
| GABELLI FUNDS LLC | 0 | 110,896 | +110,896 | 0.00 | 0.09 | +0.09 | buy |
| FNY Investment Advisers, LLC | 0 | 108,951 | +108,951 | 0.00 | 4.87 | +4.87 | buy |
| Jump Financial, LLC | 4,623 | 107,000 | +102,377 | 0.01 | 0.12 | +0.11 | buy |
| WATER ISLAND CAPITAL LLC | 0 | 103,979 | +103,979 | 0.00 | 1.36 | +1.36 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 748,896 | 100,000 | -648,896 | 0.12 | 0.02 | -0.10 | sell |
| Commodore Capital LP | 833,600 | 100,000 | -733,600 | 4.94 | 0.74 | -4.21 | sell |
| GARDNER LEWIS ASSET MANAGEMENT L P | 0 | 95,495 | +95,495 | 0.00 | 2.63 | +2.63 | buy |
| Swiss National Bank | 78,900 | 91,800 | +12,900 | 0.00 | 0.01 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 90,521 | +90,521 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 90,434 | +90,434 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,653 | 85,717 | +58,064 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 363,098 | 84,659 | -278,439 | 0.01 | 0.00 | -0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 81,867 | 80,692 | -1,175 | 0.04 | 0.03 | -0.00 | sell |
| Man Group plc | 24,258 | 80,000 | +55,742 | 0.01 | 0.02 | +0.01 | buy |
| CITIGROUP INC | 36,688 | 77,348 | +40,660 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,056,133 | 75,740 | -1,980,393 | 0.02 | 0.00 | -0.02 | sell |
| GABELLI & Co INVESTMENT ADVISERS, INC. | 0 | 74,244 | +74,244 | 0.00 | 1.33 | +1.33 | buy |
| RHUMBLINE ADVISERS | 63,867 | 71,607 | +7,740 | 0.01 | 0.01 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 70,535 | +70,535 | 0.00 | 0.64 | +0.64 | buy |
| Vestcor Inc | 0 | 65,514 | +65,514 | 0.00 | 0.20 | +0.20 | buy |
| Woodline Partners LP | 610,459 | 64,500 | -545,959 | 0.24 | 0.02 | -0.21 | sell |
| ALLIANCEBERNSTEIN L.P. | 784,023 | 63,190 | -720,833 | 0.03 | 0.00 | -0.02 | sell |
| TIG Advisors, LLC | 0 | 63,055 | +63,055 | 0.00 | 0.36 | +0.36 | buy |
| DEUTSCHE BANK AG\ | 87,746 | 61,735 | -26,011 | 0.00 | 0.00 | -0.00 | sell |
| Weiss Asset Management LP | 0 | 61,041 | +61,041 | 0.00 | 0.08 | +0.08 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 122,187 | 60,102 | -62,085 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 28,480 | 60,000 | +31,520 | 0.02 | 0.03 | +0.02 | buy |
| LMR Partners LLP | 0 | 60,000 | +60,000 | 0.00 | 0.05 | +0.05 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 59,000 | +59,000 | 0.00 | 0.02 | +0.02 | buy |
| ABC ARBITRAGE SA | 0 | 57,147 | +57,147 | 0.00 | 0.76 | +0.76 | buy |
| Groupe la Francaise | 0 | 56,430 | +56,430 | 0.00 | 0.09 | +0.09 | buy |
| WELLS FARGO & COMPANY/MN | 26,310 | 56,163 | +29,853 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 52,455 | +52,455 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 49,670 | 52,342 | +2,672 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 38,420 | 51,487 | +13,067 | 0.00 | 0.00 | +0.00 | buy |
| Alberta Investment Management Corp | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| Carmignac Gestion | 0 | 47,657 | +47,657 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 0 | 46,306 | +46,306 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 50,026 | 46,196 | -3,830 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 92,502 | 45,006 | -47,496 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 408,285 | 44,164 | -364,121 | 0.01 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 20,402 | 44,063 | +23,661 | 0.06 | 0.19 | +0.13 | buy |
| CITADEL ADVISORS LLC | 166,773 | 43,937 | -122,836 | 0.01 | 0.00 | -0.01 | sell |