| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,120,465 | 1,638,147 | +517,682 | 3.82 | 5.14 | +1.31 | buy |
| PERCEPTIVE ADVISORS LLC | 2,194,821 | 2,463,451 | +268,630 | 2.69 | 3.81 | +1.12 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 575,678 | 806,936 | +231,258 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 280,016 | 350,017 | +70,001 | 0.09 | 0.11 | +0.03 | buy |
| FRED ALGER MANAGEMENT, LLC | 10,383 | 80,037 | +69,654 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 80,518 | 95,715 | +15,197 | 0.02 | 0.03 | +0.01 | buy |
| Hudson Bay Capital Management LP | 30,000 | 42,955 | +12,955 | 0.01 | 0.02 | +0.01 | buy |
| Ikarian Capital, LLC | 272,752 | 278,034 | +5,282 | 4.06 | 4.75 | +0.69 | buy |
| PROFUND ADVISORS LLC | 14,795 | 16,216 | +1,421 | 0.03 | 0.04 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 673 | 1,327 | +654 | 0.01 | 0.02 | +0.01 | buy |
| Ellsworth Advisors, LLC | 11,732 | 11,691 | -41 | 0.17 | 0.21 | +0.04 | sell |
| VIRTUS ADVISERS, LLC | 2,524 | 2,296 | -228 | 0.06 | 0.06 | +0.00 | sell |
| ADVISORY RESEARCH INC | 11,320 | 6,620 | -4,700 | 0.06 | 0.04 | -0.02 | sell |
| HighVista Strategies LLC | 72,298 | 54,083 | -18,215 | 1.39 | 1.15 | -0.24 | sell |
| Soleus Capital Management, L.P. | 213,000 | 154,416 | -58,584 | 1.00 | 0.72 | -0.28 | sell |
| ArrowMark Colorado Holdings LLC | 382,430 | 269,765 | -112,665 | 0.18 | 0.15 | -0.03 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,440,730 | 1,239,403 | -201,327 | 0.77 | 0.74 | -0.03 | sell |
| Commodore Capital LP | 1,150,000 | 828,778 | -321,222 | 5.45 | 4.45 | -1.00 | sell |
| Fairmount Funds Management LLC | 2,884,492 | 2,451,819 | -432,673 | 17.15 | 13.56 | -3.59 | sell |
| Avoro Capital Advisors LLC | 1,600,000 | 812,500 | -787,500 | 0.92 | 0.58 | -0.33 | sell |