| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 19,991,024 | 0 | 25.23 | 30.56 | +5.33 | hold |
| FMR LLC | 8,868,095 | 9,654,352 | +786,257 | 0.04 | 0.06 | +0.02 | buy |
| Paradigm Biocapital Advisors LP | 4,571,678 | 5,000,000 | +428,322 | 13.27 | 17.90 | +4.63 | buy |
| VANGUARD GROUP INC | 3,776,016 | 4,133,625 | +357,609 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,549,077 | 2,979,235 | +430,158 | 4.67 | 6.54 | +1.87 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,697,267 | 2,697,267 | 0 | 22.46 | 28.71 | +6.24 | hold |
| Fairmount Funds Management LLC | 1,924,626 | 1,687,064 | -237,562 | 16.50 | 13.99 | -2.50 | sell |
| STATE STREET CORP | 1,326,040 | 1,243,099 | -82,941 | 0.00 | 0.01 | +0.00 | sell |
| Woodline Partners LP | 886,077 | 1,193,679 | +307,602 | 0.64 | 1.03 | +0.39 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 754,138 | 1,082,277 | +328,139 | 0.01 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 611,435 | 1,011,837 | +400,402 | 0.01 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 1,487,756 | 940,000 | -547,756 | 7.70 | 6.01 | -1.69 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,607 | 863,957 | +167,350 | 0.51 | 0.76 | +0.25 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 782,181 | 855,610 | +73,429 | 0.01 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 578,130 | 627,742 | +49,612 | 0.21 | 0.31 | +0.10 | buy |
| Pictet Asset Management Holding SA | 568,884 | 621,133 | +52,249 | 0.05 | 0.07 | +0.02 | buy |
| MORGAN STANLEY | 386,657 | 471,717 | +85,060 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 255,989 | 429,994 | +174,005 | 0.59 | 1.43 | +0.85 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 465,710 | 371,441 | -94,269 | 8.72 | 8.56 | -0.16 | sell |
| Polar Capital Holdings Plc | 287,500 | 362,500 | +75,000 | 0.13 | 0.18 | +0.05 | buy |
| First Turn Management, LLC | 252,276 | 359,114 | +106,838 | 3.11 | 5.82 | +2.70 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 337,500 | +137,500 | 2.39 | 5.36 | +2.97 | buy |
| NORTHERN TRUST CORP | 264,710 | 319,780 | +55,070 | 0.00 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 262,008 | 318,367 | +56,359 | 0.12 | 0.19 | +0.07 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 265,291 | 315,827 | +50,536 | 0.00 | 0.01 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 253,205 | 313,004 | +59,799 | 0.07 | 0.12 | +0.05 | buy |
| LORD, ABBETT & CO. LLC | 238,205 | 308,362 | +70,157 | 0.06 | 0.10 | +0.04 | buy |
| ArrowMark Colorado Holdings LLC | 139,891 | 295,152 | +155,261 | 0.13 | 0.39 | +0.26 | buy |
| SAMLYN CAPITAL, LLC | 229,325 | 281,233 | +51,908 | 0.30 | 0.46 | +0.17 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 280,000 | +280,000 | 0.00 | 0.05 | +0.05 | buy |
| NORGES BANK | 332,681 | 274,644 | -58,037 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 285,383 | 263,607 | -21,776 | 0.00 | 0.01 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 282,662 | 262,388 | -20,274 | 0.05 | 0.06 | +0.01 | sell |
| DIMENSIONAL FUND ADVISORS LP | 348,089 | 258,037 | -90,052 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 399,199 | 245,581 | -153,618 | 0.04 | 0.03 | -0.01 | sell |
| CITADEL ADVISORS LLC | 5,784 | 242,558 | +236,774 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 27,887 | 180,352 | +152,465 | 0.00 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 119,789 | 176,281 | +56,492 | 0.12 | 0.21 | +0.09 | buy |
| Invesco Ltd. | 15,220 | 170,446 | +155,226 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 194,691 | 159,628 | -35,063 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 161,200 | 152,200 | -9,000 | 0.03 | 0.04 | +0.01 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 172,629 | 150,199 | -22,430 | 0.01 | 0.01 | +0.00 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.08 | +0.08 | buy |
| MARSHALL WACE, LLP | 84,081 | 141,704 | +57,623 | 0.01 | 0.02 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 148,609 | 137,821 | -10,788 | 0.00 | 0.00 | +0.00 | sell |
| Alyeska Investment Group, L.P. | 0 | 115,000 | +115,000 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 137,883 | 112,228 | -25,655 | 0.00 | 0.00 | +0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 189,563 | 110,459 | -79,104 | 0.01 | 0.01 | -0.00 | sell |
| Nicholas Investment Partners, LP | 125,495 | 100,071 | -25,424 | 0.99 | 0.94 | -0.05 | sell |
| CITIGROUP INC | 82,278 | 94,534 | +12,256 | 0.01 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 82,750 | 90,000 | +7,250 | 0.60 | 0.75 | +0.14 | buy |
| BANK OF AMERICA CORP /DE/ | 94,244 | 88,781 | -5,463 | 0.00 | 0.00 | +0.00 | sell |
| Logos Global Management LP | 195,000 | 75,000 | -120,000 | 1.70 | 0.86 | -0.85 | sell |
| Soleus Capital Management, L.P. | 171,788 | 74,357 | -97,431 | 1.15 | 0.63 | -0.52 | sell |
| Polar Asset Management Partners Inc. | 0 | 68,780 | +68,780 | 0.00 | 0.17 | +0.17 | buy |
| BARCLAYS PLC | 27,353 | 68,107 | +40,754 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 65,831 | +65,831 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 65,000 | +65,000 | 0.00 | 0.33 | +0.33 | buy |
| Opaleye Management Inc. | 59,300 | 64,000 | +4,700 | 1.03 | 1.09 | +0.06 | buy |
| Swiss National Bank | 57,800 | 57,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 151,601 | 52,238 | -99,363 | 3.59 | 1.66 | -1.93 | sell |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.37 | +0.37 | buy |
| RHUMBLINE ADVISERS | 46,611 | 48,558 | +1,947 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 87,693 | 47,460 | -40,233 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 53,395 | 46,614 | -6,781 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,795 | 45,705 | +22,910 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 20,286 | 42,857 | +22,571 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 64,692 | 42,847 | -21,845 | 0.02 | 0.02 | -0.00 | sell |
| Informed Momentum Co LLC | 0 | 40,130 | +40,130 | 0.00 | 0.61 | +0.61 | buy |
| TD ASSET MANAGEMENT INC | 0 | 39,866 | +39,866 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,120 | 39,120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global IMC LLC | 0 | 38,310 | +38,310 | 0.00 | 0.79 | +0.79 | buy |
| Man Group plc | 118,496 | 37,289 | -81,207 | 0.02 | 0.01 | -0.01 | sell |
| Monashee Investment Management LLC | 0 | 35,000 | +35,000 | 0.00 | 0.39 | +0.39 | buy |
| JPMORGAN CHASE & CO | 32,045 | 34,709 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 44,414 | 33,764 | -10,650 | 0.01 | 0.02 | +0.00 | sell |
| Squarepoint Ops LLC | 77,099 | 33,466 | -43,633 | 0.02 | 0.01 | -0.01 | sell |
| Legal & General Group Plc | 32,245 | 32,675 | +430 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 41,863 | 29,785 | -12,078 | 0.06 | 0.06 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,862 | 29,774 | +4,912 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 28,698 | 29,018 | +320 | 0.80 | 1.02 | +0.23 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,870 | 28,333 | -537 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,202 | 26,892 | -4,310 | 0.01 | 0.01 | +0.00 | sell |
| Trek Financial, LLC | 0 | 24,195 | +24,195 | 0.00 | 0.19 | +0.19 | buy |
| State of New Jersey Common Pension Fund D | 0 | 23,575 | +23,575 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 42,888 | 23,400 | -19,488 | 0.44 | 0.31 | -0.14 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 16,559 | 21,516 | +4,957 | 0.10 | 0.10 | -0.00 | buy |
| Nebula Research & Development LLC | 0 | 21,500 | +21,500 | 0.00 | 0.26 | +0.26 | buy |
| Walleye Capital LLC | 0 | 20,071 | +20,071 | 0.00 | 0.02 | +0.02 | buy |
| Exome Asset Management LLC | 0 | 19,945 | +19,945 | 0.00 | 1.38 | +1.38 | buy |
| MetLife Investment Management, LLC | 18,506 | 19,737 | +1,231 | 0.01 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 67,361 | 19,649 | -47,712 | 0.01 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 15,238 | 19,645 | +4,407 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 9,472 | 19,472 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,701 | 19,466 | -9,235 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 17,183 | 18,523 | +1,340 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 12,716 | 17,716 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 17,000 | 17,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| WELLS FARGO & COMPANY/MN | 15,762 | 16,025 | +263 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 13,063 | 15,894 | +2,831 | 0.00 | 0.00 | +0.00 | buy |