| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 2,549,077 | 2,979,235 | +430,158 | 4.66 | 6.45 | +1.79 | buy |
| Paradigm Biocapital Advisors LP | 4,571,678 | 5,000,000 | +428,322 | 13.27 | 17.90 | +4.63 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 754,138 | 1,082,277 | +328,139 | 0.01 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 886,077 | 1,193,679 | +307,602 | 0.64 | 1.03 | +0.39 | buy |
| Rock Springs Capital Management LP | 255,989 | 429,994 | +174,005 | 0.58 | 1.43 | +0.85 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,607 | 863,957 | +167,350 | 0.51 | 0.76 | +0.25 | buy |
| ArrowMark Colorado Holdings LLC | 139,891 | 295,152 | +155,261 | 0.13 | 0.39 | +0.26 | buy |
| D. E. Shaw & Co., Inc. | 399,199 | 245,581 | +153,618 | 0.05 | 0.04 | 0.00 | sell |
| Affinity Asset Advisors, LLC | 200,000 | 337,500 | +137,500 | 2.39 | 5.36 | +2.97 | buy |
| First Turn Management, LLC | 252,276 | 359,114 | +106,838 | 3.11 | 5.82 | +2.70 | buy |
| Polar Capital Holdings Plc | 287,500 | 362,500 | +75,000 | 0.13 | 0.18 | +0.05 | buy |
| LORD, ABBETT & CO. LLC | 238,205 | 308,362 | +70,157 | 0.06 | 0.10 | +0.04 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 119,789 | 176,281 | +56,492 | 0.12 | 0.21 | +0.09 | buy |
| Candriam S.C.A. | 262,008 | 318,367 | +56,359 | 0.12 | 0.19 | +0.07 | buy |
| SAMLYN CAPITAL, LLC | 229,325 | 281,233 | +51,908 | 0.29 | 0.44 | +0.15 | buy |
| FRED ALGER MANAGEMENT, LLC | 578,130 | 627,742 | +49,612 | 0.21 | 0.31 | +0.10 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 172,629 | 150,199 | +22,430 | 0.01 | 0.02 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 282,662 | 262,388 | +20,274 | 0.05 | 0.07 | 0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 44,414 | 33,764 | +10,650 | 0.01 | 0.02 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 82,750 | 90,000 | +7,250 | 0.60 | 0.75 | +0.14 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 16,559 | 21,516 | +4,957 | 0.10 | 0.10 | 0.00 | buy |
| Opaleye Management Inc. | 59,300 | 64,000 | +4,700 | 1.03 | 1.09 | +0.06 | buy |
| China Universal Asset Management Co., Ltd. | 6,945 | 11,417 | +4,472 | 0.07 | 0.13 | +0.05 | buy |
| PROFUND ADVISORS LLC | 12,124 | 8,829 | +3,295 | 0.03 | 0.03 | 0.00 | sell |
| ProShare Advisors LLC | 7,210 | 10,052 | +2,842 | 0.00 | 0.00 | 0.00 | buy |
| NEOS Investment Management LLC | 9,817 | 10,477 | +660 | 0.03 | 0.03 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,941 | 4,600 | +659 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 28,698 | 29,018 | +320 | 0.80 | 1.02 | +0.23 | buy |
| VIRTUS ADVISERS, LLC | 1,146 | 1,165 | +19 | 0.04 | 0.06 | +0.01 | buy |
| Harvest Fund Management Co., Ltd | 306 | 0 | -306 | 0.00 | 0.00 | -0.00 | sell |
| E Fund Management Co., Ltd. | 3,929 | 2,753 | -1,176 | 0.02 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 6,456 | 2,700 | -3,756 | 0.01 | 0.01 | -0.01 | sell |
| Legato Capital Management LLC | 11,807 | 7,943 | -3,864 | 0.12 | 0.10 | -0.02 | sell |
| Edgestream Partners, L.P. | 15,695 | 2,829 | -12,866 | 0.06 | 0.01 | -0.04 | sell |
| Parkman Healthcare Partners LLC | 42,888 | 23,400 | -19,488 | 0.44 | 0.31 | -0.14 | sell |
| Rafferty Asset Management, LLC | 64,692 | 42,847 | -21,845 | 0.02 | 0.02 | -0.00 | sell |
| Nicholas Investment Partners, LP | 125,495 | 100,071 | -25,424 | 0.99 | 0.94 | -0.05 | sell |
| Aberdeen Group plc | 87,693 | 47,460 | -40,233 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 465,710 | 371,441 | -94,269 | 8.72 | 8.56 | -0.16 | sell |
| Soleus Capital Management, L.P. | 171,788 | 74,357 | -97,431 | 1.15 | 0.63 | -0.52 | sell |
| Ikarian Capital, LLC | 151,601 | 52,238 | -99,363 | 3.59 | 1.66 | -1.93 | sell |
| Logos Global Management LP | 195,000 | 75,000 | -120,000 | 1.70 | 0.86 | -0.85 | sell |
| Fairmount Funds Management LLC | 1,924,626 | 1,687,064 | -237,562 | 16.50 | 13.99 | -2.50 | sell |
| Commodore Capital LP | 1,487,756 | 940,000 | -547,756 | 7.70 | 6.01 | -1.69 | sell |