| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,868,095 | 9,654,352 | +786,257 | 0.04 | 0.06 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 2,549,077 | 2,979,235 | +430,158 | 4.67 | 6.54 | +1.87 | buy |
| Paradigm Biocapital Advisors LP | 4,571,678 | 5,000,000 | +428,322 | 13.27 | 17.90 | +4.63 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 611,435 | 1,011,837 | +400,402 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 3,776,016 | 4,133,625 | +357,609 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 754,138 | 1,082,277 | +328,139 | 0.01 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 886,077 | 1,193,679 | +307,602 | 0.64 | 1.03 | +0.39 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 280,000 | +280,000 | 0.00 | 0.05 | +0.05 | buy |
| CITADEL ADVISORS LLC | 5,784 | 242,558 | +236,774 | 0.00 | 0.03 | +0.03 | buy |
| Rock Springs Capital Management LP | 255,989 | 429,994 | +174,005 | 0.59 | 1.43 | +0.85 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 696,607 | 863,957 | +167,350 | 0.51 | 0.76 | +0.25 | buy |
| ArrowMark Colorado Holdings LLC | 139,891 | 295,152 | +155,261 | 0.13 | 0.39 | +0.26 | buy |
| Invesco Ltd. | 15,220 | 170,446 | +155,226 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 27,887 | 180,352 | +152,465 | 0.00 | 0.02 | +0.01 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.08 | +0.08 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 337,500 | +137,500 | 2.39 | 5.36 | +2.97 | buy |
| Alyeska Investment Group, L.P. | 0 | 115,000 | +115,000 | 0.00 | 0.06 | +0.06 | buy |
| First Turn Management, LLC | 252,276 | 359,114 | +106,838 | 3.11 | 5.82 | +2.70 | buy |
| MORGAN STANLEY | 386,657 | 471,717 | +85,060 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 287,500 | 362,500 | +75,000 | 0.13 | 0.18 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 782,181 | 855,610 | +73,429 | 0.01 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 238,205 | 308,362 | +70,157 | 0.06 | 0.10 | +0.04 | buy |
| Polar Asset Management Partners Inc. | 0 | 68,780 | +68,780 | 0.00 | 0.17 | +0.17 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 65,831 | +65,831 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 65,000 | +65,000 | 0.00 | 0.33 | +0.33 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 253,205 | 313,004 | +59,799 | 0.07 | 0.12 | +0.05 | buy |
| MARSHALL WACE, LLP | 84,081 | 141,704 | +57,623 | 0.01 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 119,789 | 176,281 | +56,492 | 0.12 | 0.21 | +0.09 | buy |
| Candriam S.C.A. | 262,008 | 318,367 | +56,359 | 0.12 | 0.19 | +0.07 | buy |
| NORTHERN TRUST CORP | 264,710 | 319,780 | +55,070 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 568,884 | 621,133 | +52,249 | 0.05 | 0.07 | +0.02 | buy |
| SAMLYN CAPITAL, LLC | 229,325 | 281,233 | +51,908 | 0.30 | 0.46 | +0.17 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 265,291 | 315,827 | +50,536 | 0.00 | 0.01 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.37 | +0.37 | buy |
| FRED ALGER MANAGEMENT, LLC | 578,130 | 627,742 | +49,612 | 0.21 | 0.31 | +0.10 | buy |
| BARCLAYS PLC | 27,353 | 68,107 | +40,754 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 40,130 | +40,130 | 0.00 | 0.61 | +0.61 | buy |
| TD ASSET MANAGEMENT INC | 0 | 39,866 | +39,866 | 0.00 | 0.00 | +0.00 | buy |
| Global IMC LLC | 0 | 38,310 | +38,310 | 0.00 | 0.79 | +0.79 | buy |
| Monashee Investment Management LLC | 0 | 35,000 | +35,000 | 0.00 | 0.39 | +0.39 | buy |
| Trek Financial, LLC | 0 | 24,195 | +24,195 | 0.00 | 0.19 | +0.19 | buy |
| State of New Jersey Common Pension Fund D | 0 | 23,575 | +23,575 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,795 | 45,705 | +22,910 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 20,286 | 42,857 | +22,571 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 21,500 | +21,500 | 0.00 | 0.26 | +0.26 | buy |
| Walleye Capital LLC | 0 | 20,071 | +20,071 | 0.00 | 0.02 | +0.02 | buy |
| Exome Asset Management LLC | 0 | 19,945 | +19,945 | 0.00 | 1.38 | +1.38 | buy |
| Artia Global Partners LP | 0 | 15,437 | +15,437 | 0.00 | 0.45 | +0.45 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 12,264 | +12,264 | 0.00 | 0.08 | +0.08 | buy |
| CITIGROUP INC | 82,278 | 94,534 | +12,256 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 0 | 11,640 | +11,640 | 0.00 | 0.24 | +0.24 | buy |
| Verition Fund Management LLC | 0 | 10,446 | +10,446 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 10,442 | +10,442 | 0.00 | 0.18 | +0.18 | buy |
| Ensign Peak Advisors, Inc | 9,472 | 19,472 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 7,783 | +7,783 | 0.00 | 0.01 | +0.01 | buy |
| Virtu Financial LLC | 0 | 7,417 | +7,417 | 0.00 | 0.04 | +0.04 | buy |
| Rhenman & Partners Asset Management AB | 82,750 | 90,000 | +7,250 | 0.60 | 0.75 | +0.14 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 6,451 | 13,590 | +7,139 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 6,411 | +6,411 | 0.00 | 0.05 | +0.05 | buy |
| JANUS HENDERSON GROUP PLC | 12,716 | 17,716 | +5,000 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.83 | +0.83 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 5,000 | +5,000 | 0.00 | 0.03 | +0.03 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 16,559 | 21,516 | +4,957 | 0.10 | 0.10 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 24,862 | 29,774 | +4,912 | 0.00 | 0.01 | +0.00 | buy |
| Advantage Alpha Capital Partners LP | 0 | 4,851 | +4,851 | 0.00 | 0.11 | +0.11 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 4,789 | +4,789 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 59,300 | 64,000 | +4,700 | 1.03 | 1.09 | +0.06 | buy |
| Twin Tree Management, LP | 0 | 4,667 | +4,667 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 6,945 | 11,417 | +4,472 | 0.07 | 0.13 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 15,238 | 19,645 | +4,407 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 4,115 | +4,115 | 0.00 | 0.18 | +0.18 | buy |
| SG Americas Securities, LLC | 3,356 | 7,385 | +4,029 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,255 | +3,255 | 0.00 | 0.01 | +0.01 | buy |
| FORA Capital, LLC | 0 | 3,202 | +3,202 | 0.00 | 0.04 | +0.04 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 7,646 | 10,605 | +2,959 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 7,210 | 10,052 | +2,842 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 13,063 | 15,894 | +2,831 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 32,045 | 34,709 | +2,664 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 2,605 | +2,605 | 0.00 | 0.00 | +0.00 | buy |
| TORNO CAPITAL, LLC | 0 | 2,500 | +2,500 | 0.00 | 0.33 | +0.33 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 2,924 | 5,324 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 2,267 | +2,267 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 2,243 | +2,243 | 0.00 | 0.00 | +0.00 | buy |
| PORTLAND INVESTMENT COUNSEL INC. | 0 | 2,000 | +2,000 | 0.00 | 0.07 | +0.07 | buy |
| RHUMBLINE ADVISERS | 46,611 | 48,558 | +1,947 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 7,700 | 9,300 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,564 | +1,564 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 17,183 | 18,523 | +1,340 | 0.01 | 0.01 | +0.00 | buy |
| M&T BANK CORP | 6,018 | 7,281 | +1,263 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 18,506 | 19,737 | +1,231 | 0.01 | 0.01 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 6,445 | 7,412 | +967 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 9,817 | 10,477 | +660 | 0.03 | 0.03 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 3,941 | 4,600 | +659 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 32,245 | 32,675 | +430 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,765 | 2,147 | +382 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,129 | 3,509 | +380 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 28,698 | 29,018 | +320 | 0.80 | 1.02 | +0.23 | buy |
| Arizona State Retirement System | 8,215 | 8,512 | +297 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 15,762 | 16,025 | +263 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 927 | 1,176 | +249 | 0.00 | 0.00 | +0.00 | buy |