| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,246,456 | +1,246,456 | 0.00 | 1.33 | +1.33 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,576,374 | 2,300,865 | +724,491 | 0.02 | 0.03 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,197,187 | 1,674,009 | +476,822 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,782,581 | 2,188,674 | +406,093 | 0.07 | 0.09 | +0.02 | buy |
| Polar Capital Holdings Plc | 816,087 | 1,022,225 | +206,138 | 0.33 | 0.43 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 1,375,180 | 1,562,336 | +187,156 | 3.94 | 3.90 | -0.03 | buy |
| Woodline Partners LP | 904,232 | 1,069,520 | +165,288 | 0.36 | 0.44 | +0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 235,583 | 372,300 | +136,717 | 3.68 | 4.66 | +0.98 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 996,845 | 1,093,993 | +97,148 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,490,279 | 1,574,747 | +84,468 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 4,524,124 | 4,605,007 | +80,883 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 136,744 | 213,121 | +76,377 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 320,798 | 394,754 | +73,956 | 4.57 | 5.13 | +0.56 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 346,506 | 404,553 | +58,047 | 0.00 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 50,000 | 101,066 | +51,066 | 0.01 | 0.03 | +0.01 | buy |
| FMR LLC | 9,968,846 | 10,013,237 | +44,391 | 0.04 | 0.05 | +0.00 | buy |
| HighVista Strategies LLC | 50,460 | 93,294 | +42,834 | 1.41 | 1.98 | +0.56 | buy |
| AMERIPRISE FINANCIAL INC | 484,343 | 527,050 | +42,707 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 29,966 | 71,700 | +41,734 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 341,774 | 381,496 | +39,722 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 4,046,256 | 4,085,795 | +39,539 | 0.01 | 0.01 | +0.00 | buy |
| Candriam S.C.A. | 301,259 | 329,721 | +28,462 | 0.13 | 0.15 | +0.02 | buy |
| Jefferies Financial Group Inc. | 0 | 25,160 | +25,160 | 0.00 | 0.02 | +0.02 | buy |
| Commodore Capital LP | 1,375,000 | 1,400,000 | +25,000 | 7.41 | 5.91 | -1.49 | buy |
| Vestal Point Capital, LP | 1,075,000 | 1,100,000 | +25,000 | 4.32 | 4.32 | -0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 23,787 | +23,787 | 0.00 | 0.01 | +0.01 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 22,500 | +22,500 | 0.00 | 0.04 | +0.04 | buy |
| Bridgewater Associates, LP | 0 | 22,057 | +22,057 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 103,722 | 124,178 | +20,456 | 0.70 | 0.82 | +0.12 | buy |
| SG Americas Securities, LLC | 0 | 18,836 | +18,836 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 40,355 | 55,601 | +15,246 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,795,373 | 1,810,420 | +15,047 | 0.02 | 0.02 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 123,219 | 134,742 | +11,523 | 0.01 | 0.01 | +0.00 | buy |
| Russell Investments Group, Ltd. | 81,609 | 92,484 | +10,875 | 0.01 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 98,900 | 109,584 | +10,684 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 7,425 | +7,425 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 7,289 | +7,289 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 22,362 | 29,525 | +7,163 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 5,702 | +5,702 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 5,504 | 10,769 | +5,265 | 0.01 | 0.02 | +0.01 | buy |
| Creative Planning | 17,288 | 22,520 | +5,232 | 0.00 | 0.00 | +0.00 | buy |
| Empire Financial Management Company, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.10 | +0.10 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,736 | 28,062 | +4,326 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 3,960 | +3,960 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 8,871 | 12,651 | +3,780 | 0.08 | 0.12 | +0.04 | buy |
| Graham Capital Management, L.P. | 0 | 3,675 | +3,675 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 3,516 | +3,516 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 7,000 | 10,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 25,720 | 28,881 | +3,161 | 0.01 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30,567 | 33,084 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 135,613 | 137,945 | +2,332 | 0.01 | 0.01 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,822 | 11,894 | +2,072 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 143,375 | 145,404 | +2,029 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 10,863 | 12,839 | +1,976 | 0.01 | 0.01 | +0.00 | buy |
| Handelsbanken Fonder AB | 12,000 | 13,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 75,800 | 77,200 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 31,762 | 33,007 | +1,245 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 31,762 | 33,007 | +1,245 | 0.64 | 0.24 | -0.41 | buy |
| Arax Advisory Partners | 0 | 1,076 | +1,076 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,556 | 28,581 | +1,025 | 0.01 | 0.01 | +0.00 | buy |
| EASTERN BANK | 0 | 604 | +604 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 119,623 | 120,190 | +567 | 1.06 | 1.14 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 159,630 | 160,134 | +504 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 3,802 | 4,253 | +451 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 441 | +441 | 0.00 | 0.02 | +0.02 | buy |
| PROFUND ADVISORS LLC | 10,408 | 10,687 | +279 | 0.03 | 0.03 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 1,207 | 1,461 | +254 | 0.03 | 0.04 | +0.01 | buy |
| J. Goldman & Co LP | 2,700 | 2,936 | +236 | 0.01 | 0.01 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 3,056 | 3,290 | +234 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 11,558 | 11,778 | +220 | 0.01 | 0.01 | +0.00 | buy |
| US BANCORP \DE\ | 1,882 | 2,070 | +188 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 216,422 | 216,556 | +134 | 0.13 | 0.13 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 100 | 175 | +75 | 0.00 | 0.00 | +0.00 | buy |
| Salomon & Ludwin, LLC | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 5,405 | 5,475 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,632 | 1,694 | +62 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 49 | +49 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 5,930 | 5,968 | +38 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 3,346 | 3,380 | +34 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 194 | 227 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Marquette Asset Management, LLC | 0 | 32 | +32 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 49,940 | 49,968 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 29 | 55 | +26 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 269 | 289 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,564 | 2,577 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 10 | 19 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 8 | 16 | +8 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 21 | 27 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 81 | 86 | +5 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1,213 | 1,217 | +4 | 0.00 | 0.00 | -0.00 | buy |
| COMERICA BANK | 77 | 80 | +3 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,991,024 | 17,991,024 | 0 | 24.91 | 23.84 | -1.07 | hold |
| BESSEMER GROUP INC | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MassMutual Private Wealth & Trust, FSB | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.19 | 0.17 | -0.03 | hold |