| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,991,024 | 17,991,024 | 0 | 24.91 | 23.84 | -1.07 | hold |
| FMR LLC | 9,968,846 | 10,013,237 | +44,391 | 0.04 | 0.05 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,269,433 | 5,269,433 | 0 | 17.17 | 13.48 | -3.68 | hold |
| VANGUARD GROUP INC | 4,524,124 | 4,605,007 | +80,883 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,046,256 | 4,085,795 | +39,539 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,576,374 | 2,300,865 | +724,491 | 0.02 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 1,782,581 | 2,188,674 | +406,093 | 0.07 | 0.09 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,795,373 | 1,810,420 | +15,047 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,197,187 | 1,674,009 | +476,822 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,490,279 | 1,574,747 | +84,468 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,375,180 | 1,562,336 | +187,156 | 3.94 | 3.90 | -0.03 | buy |
| Commodore Capital LP | 1,375,000 | 1,400,000 | +25,000 | 7.41 | 5.91 | -1.49 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,246,456 | +1,246,456 | 0.00 | 1.33 | +1.33 | buy |
| Vestal Point Capital, LP | 1,075,000 | 1,100,000 | +25,000 | 4.32 | 4.32 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 996,845 | 1,093,993 | +97,148 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 904,232 | 1,069,520 | +165,288 | 0.36 | 0.44 | +0.07 | buy |
| Polar Capital Holdings Plc | 816,087 | 1,022,225 | +206,138 | 0.33 | 0.43 | +0.10 | buy |
| T. Rowe Price Investment Management, Inc. | 1,094,568 | 1,021,236 | -73,332 | 0.05 | 0.05 | +0.00 | sell |
| BRAIDWELL LP | 1,175,876 | 1,012,982 | -162,894 | 3.07 | 2.60 | -0.47 | sell |
| Fairmount Funds Management LLC | 727,563 | 727,563 | 0 | 7.19 | 5.66 | -1.53 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 577,500 | 574,500 | -3,000 | 0.07 | 0.08 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 484,343 | 527,050 | +42,707 | 0.01 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 535,445 | 444,436 | -91,009 | 0.01 | 0.01 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 346,506 | 404,553 | +58,047 | 0.00 | 0.01 | +0.00 | buy |
| First Turn Management, LLC | 320,798 | 394,754 | +73,956 | 4.57 | 5.13 | +0.56 | buy |
| Pictet Asset Management Holding SA | 589,832 | 384,576 | -205,256 | 0.05 | 0.03 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 415,000 | 384,417 | -30,583 | 4.68 | 3.09 | -1.59 | sell |
| NORTHERN TRUST CORP | 341,774 | 381,496 | +39,722 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 235,583 | 372,300 | +136,717 | 3.68 | 4.66 | +0.98 | buy |
| AMERICAN CENTURY COMPANIES INC | 374,698 | 362,931 | -11,767 | 0.02 | 0.02 | +0.00 | sell |
| ArrowMark Colorado Holdings LLC | 369,858 | 362,585 | -7,273 | 0.51 | 0.58 | +0.07 | sell |
| Candriam S.C.A. | 301,259 | 329,721 | +28,462 | 0.13 | 0.15 | +0.02 | buy |
| MORGAN STANLEY | 422,722 | 275,110 | -147,612 | 0.00 | 0.00 | -0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 216,422 | 216,556 | +134 | 0.13 | 0.13 | +0.00 | buy |
| UBS Group AG | 136,744 | 213,121 | +76,377 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 257,940 | 161,186 | -96,754 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 159,630 | 160,134 | +504 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 143,375 | 145,404 | +2,029 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 143,937 | 143,937 | 0 | 0.11 | 0.09 | -0.02 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 135,613 | 137,945 | +2,332 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 123,219 | 134,742 | +11,523 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 138,969 | 131,028 | -7,941 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 149,606 | 126,880 | -22,726 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 103,722 | 124,178 | +20,456 | 0.70 | 0.82 | +0.12 | buy |
| Parkman Healthcare Partners LLC | 119,623 | 120,190 | +567 | 1.06 | 1.14 | +0.09 | buy |
| TD ASSET MANAGEMENT INC | 98,900 | 109,584 | +10,684 | 0.01 | 0.01 | +0.00 | buy |
| Fisher Asset Management, LLC | 114,761 | 106,424 | -8,337 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 50,000 | 101,066 | +51,066 | 0.01 | 0.03 | +0.01 | buy |
| HighVista Strategies LLC | 50,460 | 93,294 | +42,834 | 1.41 | 1.98 | +0.56 | buy |
| Russell Investments Group, Ltd. | 81,609 | 92,484 | +10,875 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 92,773 | 91,633 | -1,140 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 91,439 | 88,503 | -2,936 | 0.03 | 0.03 | -0.00 | sell |
| Soleus Capital Management, L.P. | 125,000 | 88,000 | -37,000 | 0.66 | 0.41 | -0.25 | sell |
| Swiss National Bank | 75,800 | 77,200 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 76,688 | 76,688 | 0 | 0.01 | 0.01 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 29,966 | 71,700 | +41,734 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 169,539 | 65,417 | -104,122 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 66,029 | 65,212 | -817 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 66,195 | 64,462 | -1,733 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 94,840 | 64,379 | -30,461 | 0.01 | 0.01 | -0.00 | sell |
| ROYAL BANK OF CANADA | 40,355 | 55,601 | +15,246 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 52,500 | 52,500 | 0 | 0.51 | 0.50 | -0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.19 | 0.17 | -0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 49,940 | 49,968 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 48,383 | 47,981 | -402 | 0.01 | 0.01 | +0.00 | sell |
| Legal & General Group Plc | 44,837 | 43,283 | -1,554 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 40,183 | 37,886 | -2,297 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 139,193 | 35,160 | -104,033 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 38,038 | 33,757 | -4,281 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 30,567 | 33,084 | +2,517 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 31,762 | 33,007 | +1,245 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 31,762 | 33,007 | +1,245 | 0.64 | 0.24 | -0.41 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 34,000 | 30,967 | -3,033 | 0.01 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 35,782 | 30,886 | -4,896 | 0.02 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 42,975 | 30,872 | -12,103 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 63,840 | 30,226 | -33,614 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 22,362 | 29,525 | +7,163 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 25,720 | 28,881 | +3,161 | 0.01 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,556 | 28,581 | +1,025 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,736 | 28,062 | +4,326 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 33,714 | 27,665 | -6,049 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 156,788 | 27,311 | -129,477 | 0.01 | 0.00 | -0.01 | sell |
| Jefferies Financial Group Inc. | 0 | 25,160 | +25,160 | 0.00 | 0.02 | +0.02 | buy |
| MetLife Investment Management, LLC | 25,706 | 25,087 | -619 | 0.01 | 0.01 | -0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 23,787 | +23,787 | 0.00 | 0.01 | +0.01 | buy |
| Creative Planning | 17,288 | 22,520 | +5,232 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 22,500 | +22,500 | 0.00 | 0.04 | +0.04 | buy |
| Bridgewater Associates, LP | 0 | 22,057 | +22,057 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 0 | 18,836 | +18,836 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 72,692 | 18,388 | -54,304 | 0.01 | 0.00 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 17,000 | 17,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hudson Bay Capital Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 22,886 | 14,953 | -7,933 | 0.02 | 0.01 | -0.00 | sell |
| Aquatic Capital Management LLC | 27,545 | 14,707 | -12,838 | 0.04 | 0.02 | -0.02 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,182 | 14,182 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Handelsbanken Fonder AB | 12,000 | 13,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 10,863 | 12,839 | +1,976 | 0.01 | 0.01 | +0.00 | buy |
| Legato Capital Management LLC | 8,871 | 12,651 | +3,780 | 0.08 | 0.12 | +0.04 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,822 | 11,894 | +2,072 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 11,842 | 11,842 | 0 | 0.15 | 0.10 | -0.05 | hold |