| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,638,147 | 3,858,008 | +2,219,861 | 5.14 | 13.31 | +8.17 | buy |
| VANGUARD GROUP INC | 2,134,182 | 3,339,850 | +1,205,668 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 7,619,613 | 8,725,070 | +1,105,457 | 0.03 | 0.05 | +0.02 | buy |
| Commodore Capital LP | 828,778 | 1,331,037 | +502,259 | 4.45 | 8.56 | +4.11 | buy |
| PERCEPTIVE ADVISORS LLC | 2,463,451 | 2,917,991 | +454,540 | 3.81 | 4.80 | +0.99 | buy |
| LORD, ABBETT & CO. LLC | 0 | 454,151 | +454,151 | 0.00 | 0.12 | +0.12 | buy |
| Deep Track Capital, LP | 0 | 450,000 | +450,000 | 0.00 | 1.16 | +1.16 | buy |
| STATE STREET CORP | 1,260,466 | 1,701,234 | +440,768 | 0.00 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 806,936 | 1,106,382 | +299,446 | 0.01 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 80,037 | 321,952 | +241,915 | 0.02 | 0.13 | +0.11 | buy |
| CITADEL ADVISORS LLC | 0 | 209,141 | +209,141 | 0.00 | 0.02 | +0.02 | buy |
| Pictet Asset Management Holding SA | 0 | 194,004 | +194,004 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 193,000 | +193,000 | 0.00 | 4.38 | +4.38 | buy |
| Soleus Capital Management, L.P. | 154,416 | 322,888 | +168,472 | 0.72 | 2.64 | +1.92 | buy |
| D. E. Shaw & Co., Inc. | 317,276 | 468,183 | +150,907 | 0.02 | 0.05 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 80,105 | 218,629 | +138,524 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 175,000 | +125,000 | 0.75 | 2.57 | +1.82 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 545,349 | 654,747 | +109,398 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 172,233 | 273,123 | +100,890 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 89,078 | +89,078 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 9,630 | 86,707 | +77,077 | 0.00 | 0.01 | +0.01 | buy |
| Global IMC LLC | 0 | 62,656 | +62,656 | 0.00 | 1.11 | +1.11 | buy |
| UBS Group AG | 18,868 | 80,631 | +61,763 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 59,867 | +59,867 | 0.00 | 0.62 | +0.62 | buy |
| Darwin Global Management, Ltd. | 0 | 57,698 | +57,698 | 0.00 | 0.83 | +0.83 | buy |
| Ghisallo Capital Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.38 | +0.38 | buy |
| ALLIANCEBERNSTEIN L.P. | 24,170 | 66,089 | +41,919 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 40,164 | +40,164 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 197,986 | 236,881 | +38,895 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 17,721 | 55,410 | +37,689 | 0.00 | 0.02 | +0.01 | buy |
| BARCLAYS PLC | 51,243 | 88,105 | +36,862 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 83,306 | 119,414 | +36,108 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 247,106 | 280,571 | +33,465 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 95,715 | 127,046 | +31,331 | 0.03 | 0.04 | +0.01 | buy |
| JANE STREET GROUP, LLC | 54,871 | 84,724 | +29,853 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 29,381 | +29,381 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 40,842 | 68,856 | +28,014 | 0.00 | 0.01 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 86,011 | 112,929 | +26,918 | 0.43 | 0.83 | +0.40 | buy |
| BANK OF AMERICA CORP /DE/ | 64,719 | 90,596 | +25,877 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 38,546 | 62,782 | +24,236 | 0.03 | 0.06 | +0.04 | buy |
| Informed Momentum Co LLC | 27,754 | 50,180 | +22,426 | 0.25 | 0.66 | +0.41 | buy |
| FRANKLIN RESOURCES INC | 154,046 | 175,436 | +21,390 | 0.00 | 0.01 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 265,557 | 283,820 | +18,263 | 0.00 | 0.01 | +0.00 | buy |
| Atom Investors LP | 0 | 17,994 | +17,994 | 0.00 | 0.23 | +0.23 | buy |
| Woodline Partners LP | 47,850 | 65,492 | +17,642 | 0.03 | 0.05 | +0.03 | buy |
| FIRST TRUST ADVISORS LP | 0 | 17,192 | +17,192 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 15,165 | +15,165 | 0.00 | 0.01 | +0.01 | buy |
| ADVISORY RESEARCH INC | 6,620 | 21,606 | +14,986 | 0.04 | 0.25 | +0.20 | buy |
| Jefferies Financial Group Inc. | 0 | 12,400 | +12,400 | 0.00 | 0.01 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 11,700 | +11,700 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 11,500 | +11,500 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 19,508 | 29,178 | +9,670 | 0.01 | 0.03 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 45,524 | 54,478 | +8,954 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 40,863 | 49,345 | +8,482 | 0.00 | 0.00 | +0.00 | buy |
| Nebula Research & Development LLC | 0 | 8,349 | +8,349 | 0.00 | 0.19 | +0.19 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 16,700 | 24,823 | +8,123 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 3,003 | 10,484 | +7,481 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 6,988 | +6,988 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 22,287 | 28,182 | +5,895 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,396 | 40,271 | +5,875 | 0.00 | 0.00 | +0.00 | buy |
| Edgestream Partners, L.P. | 0 | 5,778 | +5,778 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF HAWAII | 0 | 5,716 | +5,716 | 0.00 | 0.02 | +0.02 | buy |
| Handelsbanken Fonder AB | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 45,200 | 50,500 | +5,300 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,327 | 6,619 | +5,292 | 0.02 | 0.09 | +0.08 | buy |
| XTX Topco Ltd | 0 | 5,089 | +5,089 | 0.00 | 0.08 | +0.08 | buy |
| LPL Financial LLC | 0 | 4,795 | +4,795 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 4,500 | +4,500 | 0.00 | 0.15 | +0.15 | buy |
| PROFUND ADVISORS LLC | 16,216 | 20,695 | +4,479 | 0.04 | 0.07 | +0.02 | buy |
| JANUS HENDERSON GROUP PLC | 8,380 | 12,843 | +4,463 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 4,346 | +4,346 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 4,200 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,509 | 27,201 | +3,692 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 3,257 | +3,257 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 3,900 | 7,100 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| High Net Worth Advisory Group LLC | 0 | 3,000 | +3,000 | 0.00 | 0.08 | +0.08 | buy |
| Mirae Asset Global Investments Co., Ltd. | 14,866 | 17,796 | +2,930 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 643 | 3,119 | +2,476 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 34,849 | 37,315 | +2,466 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 7,400 | 9,700 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| Legato Capital Management LLC | 5,639 | 7,883 | +2,244 | 0.04 | 0.08 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,207 | 22,154 | +1,947 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 4,915 | 6,798 | +1,883 | 0.02 | 0.03 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 3,849 | 5,417 | +1,568 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 6,488 | 8,054 | +1,566 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 5,852 | 7,164 | +1,312 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 11,969 | 13,209 | +1,240 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 12,782 | 14,018 | +1,236 | 0.00 | 0.01 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 7,000 | 8,075 | +1,075 | 0.01 | 0.01 | +0.00 | buy |
| Compass Wealth Management LLC | 0 | 850 | +850 | 0.00 | 0.02 | +0.02 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 2,210 | 2,960 | +750 | 0.00 | 0.01 | +0.00 | buy |
| KBC Group NV | 0 | 713 | +713 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 650 | +650 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 554 | +554 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,383 | 2,751 | +368 | 0.00 | 0.01 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 15 | 315 | +300 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 3,530 | 3,815 | +285 | 0.00 | 0.00 | +0.00 | buy |
| First Horizon Advisors, Inc. | 0 | 158 | +158 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 9,635 | 9,774 | +139 | 0.00 | 0.00 | +0.00 | buy |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 0 | 98 | +98 | 0.00 | 0.00 | +0.00 | buy |