| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 1,638,147 | 3,858,008 | +2,219,861 | 5.14 | 13.31 | +8.17 | buy |
| Commodore Capital LP | 828,778 | 1,331,037 | +502,259 | 4.45 | 8.56 | +4.11 | buy |
| PERCEPTIVE ADVISORS LLC | 2,463,451 | 2,917,991 | +454,540 | 3.78 | 4.79 | +1.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 806,936 | 1,106,382 | +299,446 | 0.01 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 80,037 | 321,952 | +241,915 | 0.02 | 0.13 | +0.11 | buy |
| Soleus Capital Management, L.P. | 154,416 | 322,888 | +168,472 | 0.72 | 2.64 | +1.92 | buy |
| Affinity Asset Advisors, LLC | 50,000 | 175,000 | +125,000 | 0.75 | 2.57 | +1.82 | buy |
| Rafferty Asset Management, LLC | 95,715 | 127,046 | +31,331 | 0.03 | 0.04 | +0.01 | buy |
| Rhenman & Partners Asset Management AB | 86,011 | 112,929 | +26,918 | 0.43 | 0.83 | +0.40 | buy |
| Informed Momentum Co LLC | 27,754 | 50,180 | +22,426 | 0.25 | 0.66 | +0.41 | buy |
| Woodline Partners LP | 47,850 | 65,492 | +17,642 | 0.03 | 0.05 | +0.03 | buy |
| ADVISORY RESEARCH INC | 6,620 | 21,606 | +14,986 | 0.04 | 0.25 | +0.20 | buy |
| TD ASSET MANAGEMENT INC | 45,524 | 54,478 | +8,954 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 1,327 | 6,619 | +5,292 | 0.02 | 0.09 | +0.08 | buy |
| PROFUND ADVISORS LLC | 16,216 | 20,695 | +4,479 | 0.04 | 0.07 | 0.00 | buy |
| Legato Capital Management LLC | 5,639 | 7,883 | +2,244 | 0.04 | 0.08 | +0.04 | buy |
| E Fund Management Co., Ltd. | 4,915 | 6,798 | +1,883 | 0.02 | 0.03 | +0.01 | buy |
| Ellsworth Advisors, LLC | 11,691 | 11,176 | -515 | 0.21 | 0.26 | +0.05 | sell |
| VIRTUS ADVISERS, LLC | 2,296 | 1,172 | -1,124 | 0.06 | 0.05 | -0.01 | sell |
| Old Well Partners, LLC | 5,800 | 4,100 | -1,700 | 0.23 | 0.28 | +0.05 | sell |
| Ikarian Capital, LLC | 278,034 | 258,142 | -19,892 | 4.75 | 5.20 | +0.45 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 25,000 | 2,730 | -22,270 | 0.02 | 0.00 | -0.02 | sell |
| Candriam S.C.A. | 350,017 | 280,009 | -70,008 | 0.11 | 0.14 | +0.03 | sell |
| ArrowMark Colorado Holdings LLC | 269,765 | 199,051 | -70,714 | 0.15 | 0.16 | +0.01 | sell |
| Nicholas Investment Partners, LP | 268,342 | 79,200 | -189,142 | 0.92 | 0.68 | -0.24 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 1,239,403 | 937,728 | -301,675 | 0.74 | 0.83 | +0.09 | sell |
| Fairmount Funds Management LLC | 2,451,819 | 1,924,626 | -527,193 | 13.56 | 14.96 | +1.40 | sell |
| Avoro Capital Advisors LLC | 812,500 | 178,921 | -633,579 | 0.58 | 0.18 | -0.40 | sell |