| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 940,000 | 1,621,600 | +681,600 | 6.01 | 9.30 | +3.29 | buy |
| Polar Capital Holdings Plc | 362,500 | 946,723 | +584,223 | 0.18 | 0.41 | +0.24 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | 680,000 | +400,000 | 0.05 | 0.09 | +0.04 | buy |
| Paradigm Biocapital Advisors LP | 5,000,000 | 5,363,379 | +363,379 | 17.90 | 14.61 | -3.29 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,082,277 | 1,297,910 | +215,633 | 0.01 | 0.01 | -0.00 | buy |
| Artia Global Partners LP | 15,437 | 204,045 | +188,608 | 0.45 | 6.44 | +5.99 | buy |
| Candriam S.C.A. | 262,008 | 368,095 | +106,087 | 0.12 | 0.17 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 262,388 | 213,882 | +48,506 | 0.07 | 0.04 | 0.00 | sell |
| Soleus Capital Management, L.P. | 74,357 | 104,357 | +30,000 | 0.63 | 0.62 | -0.01 | buy |
| SAMLYN CAPITAL, LLC | 281,233 | 310,037 | +28,804 | 0.44 | 0.37 | -0.07 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 371,441 | 400,014 | +28,573 | 8.56 | 7.00 | -1.56 | buy |
| Exome Asset Management LLC | 19,945 | 40,580 | +20,635 | 1.38 | 2.40 | +1.02 | buy |
| J. Goldman & Co LP | 2,700 | 23,100 | +20,400 | 0.01 | 0.05 | +0.04 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 33,764 | 15,155 | +18,609 | 0.02 | 0.01 | -0.01 | sell |
| Rafferty Asset Management, LLC | 42,847 | 59,276 | +16,429 | 0.02 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 1,193,679 | 1,204,927 | +11,248 | 1.03 | 0.64 | -0.39 | buy |
| HighVista Strategies LLC | 29,018 | 39,876 | +10,858 | 1.02 | 1.16 | +0.14 | buy |
| Aberdeen Group plc | 47,460 | 56,701 | +9,241 | 0.01 | 0.01 | -0.00 | buy |
| Edgestream Partners, L.P. | 2,829 | 11,724 | +8,895 | 0.01 | 0.04 | +0.03 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,411 | 12,001 | +5,590 | 0.05 | 0.08 | +0.03 | buy |
| Sandia Investment Management LP | 5,000 | 10,000 | +5,000 | 0.83 | 1.48 | +0.65 | buy |
| TD ASSET MANAGEMENT INC | 39,866 | 43,666 | +3,800 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 10,052 | 13,005 | +2,953 | 0.00 | 0.00 | 0.00 | buy |
| PROFUND ADVISORS LLC | 8,829 | 11,670 | +2,841 | 0.03 | 0.03 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,417 | 13,913 | +2,496 | 0.13 | 0.10 | -0.03 | buy |
| Nebula Research & Development LLC | 21,500 | 23,718 | +2,218 | 0.26 | 0.22 | -0.05 | buy |
| E Fund Management Co., Ltd. | 2,753 | 4,213 | +1,460 | 0.01 | 0.02 | +0.00 | buy |
| NEOS Investment Management LLC | 10,477 | 11,617 | +1,140 | 0.03 | 0.02 | -0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,516 | 20,522 | +994 | 0.10 | 0.07 | 0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 4,600 | 5,240 | +640 | 0.01 | 0.01 | -0.00 | buy |
| ArrowMark Colorado Holdings LLC | 295,152 | 295,350 | +198 | 0.39 | 0.31 | -0.08 | buy |
| Parkman Healthcare Partners LLC | 23,400 | 23,588 | +188 | 0.31 | 0.25 | -0.06 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 4,789 | 4,787 | +2 | 0.00 | 0.00 | 0.00 | sell |
| Ikarian Capital, LLC | 52,238 | 52,216 | -22 | 1.66 | 1.17 | -0.49 | sell |
| VIRTUS ADVISERS, LLC | 1,165 | 819 | -346 | 0.06 | 0.03 | -0.03 | sell |
| MARTINGALE ASSET MANAGEMENT L P | 6,104 | 5,594 | -510 | 0.01 | 0.01 | -0.00 | sell |
| Legato Capital Management LLC | 7,943 | 5,451 | -2,492 | 0.10 | 0.06 | -0.04 | sell |
| Opaleye Management Inc. | 64,000 | 58,500 | -5,500 | 1.09 | 0.80 | -0.29 | sell |
| LORD, ABBETT & CO. LLC | 308,362 | 297,588 | -10,774 | 0.10 | 0.07 | -0.03 | sell |
| Alyeska Investment Group, L.P. | 115,000 | 102,605 | -12,395 | 0.06 | 0.03 | -0.03 | sell |
| Rhenman & Partners Asset Management AB | 90,000 | 72,500 | -17,500 | 0.75 | 0.58 | -0.16 | sell |
| Nicholas Investment Partners, LP | 100,071 | 76,427 | -23,644 | 0.94 | 0.53 | -0.41 | sell |
| Polar Asset Management Partners Inc. | 68,780 | 25,580 | -43,200 | 0.15 | 0.02 | -0.13 | sell |
| First Turn Management, LLC | 359,114 | 309,521 | -49,593 | 5.82 | 4.34 | -1.48 | sell |
| Affinity Asset Advisors, LLC | 337,500 | 285,000 | -52,500 | 5.36 | 3.49 | -1.87 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 863,957 | 793,416 | -70,541 | 0.76 | 0.51 | -0.25 | sell |
| FRED ALGER MANAGEMENT, LLC | 627,742 | 308,057 | -319,685 | 0.31 | 0.11 | -0.20 | sell |
| PERCEPTIVE ADVISORS LLC | 2,979,235 | 2,619,977 | -359,258 | 6.45 | 5.65 | -0.80 | sell |
| Fairmount Funds Management LLC | 1,687,064 | 1,317,664 | -369,400 | 13.99 | 10.25 | -3.74 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,697,267 | 1,447,267 | -1,250,000 | 28.71 | 13.33 | -15.38 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 17,991,024 | -2,000,000 | 30.56 | 26.67 | -3.88 | sell |