| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 940,000 | 1,621,600 | +681,600 | 6.01 | 9.30 | +3.29 | buy |
| Vestal Point Capital, LP | 0 | 600,000 | +600,000 | 0.00 | 2.78 | +2.78 | buy |
| Polar Capital Holdings Plc | 362,500 | 946,723 | +584,223 | 0.18 | 0.41 | +0.24 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | 680,000 | +400,000 | 0.05 | 0.09 | +0.04 | buy |
| VANGUARD GROUP INC | 4,133,625 | 4,499,864 | +366,239 | 0.01 | 0.01 | -0.00 | buy |
| Paradigm Biocapital Advisors LP | 5,000,000 | 5,363,379 | +363,379 | 17.90 | 14.61 | -3.29 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,011,837 | 1,284,575 | +272,738 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 1,243,099 | 1,489,680 | +246,581 | 0.01 | 0.00 | -0.00 | buy |
| BRAIDWELL LP | 0 | 241,235 | +241,235 | 0.00 | 0.56 | +0.56 | buy |
| BlackRock, Inc. | 3,624,981 | 3,851,577 | +226,596 | 0.01 | 0.01 | -0.00 | buy |
| MARSHALL WACE, LLP | 141,704 | 361,040 | +219,336 | 0.02 | 0.04 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,082,277 | 1,297,910 | +215,633 | 0.01 | 0.01 | -0.00 | buy |
| Artia Global Partners LP | 15,437 | 204,045 | +188,608 | 0.45 | 6.44 | +5.99 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 186,385 | +186,385 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 88,781 | 262,768 | +173,987 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 65,831 | 237,556 | +171,725 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 145,234 | +145,234 | 0.00 | 2.85 | +2.85 | buy |
| Twin Tree Management, LP | 4,667 | 120,352 | +115,685 | 0.01 | 0.23 | +0.22 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 0 | 111,065 | +111,065 | 0.00 | 0.40 | +0.40 | buy |
| Trexquant Investment LP | 0 | 51,090 | +51,090 | 0.00 | 0.05 | +0.05 | buy |
| Candriam S.C.A. | 318,367 | 368,095 | +49,728 | 0.19 | 0.17 | -0.02 | buy |
| Atom Investors LP | 0 | 48,948 | +48,948 | 0.00 | 0.48 | +0.48 | buy |
| JPMORGAN CHASE & CO | 34,709 | 82,527 | +47,818 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,263 | +46,263 | 0.00 | 0.04 | +0.04 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,315 | +44,315 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 274,644 | 318,739 | +44,095 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 37,289 | 78,736 | +41,447 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 263,607 | 293,747 | +30,140 | 0.01 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 68,107 | 98,121 | +30,014 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 74,357 | 104,357 | +30,000 | 0.63 | 0.62 | -0.01 | buy |
| CITIGROUP INC | 94,534 | 124,375 | +29,841 | 0.01 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 20,071 | 49,751 | +29,680 | 0.02 | 0.04 | +0.02 | buy |
| TWINBEECH CAPITAL LP | 0 | 29,598 | +29,598 | 0.00 | 0.04 | +0.04 | buy |
| SAMLYN CAPITAL, LLC | 281,233 | 310,037 | +28,804 | 0.46 | 0.39 | -0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 371,441 | 400,014 | +28,573 | 8.56 | 7.00 | -1.56 | buy |
| Pictet Asset Management Holding SA | 621,133 | 641,781 | +20,648 | 0.07 | 0.05 | -0.02 | buy |
| Exome Asset Management LLC | 19,945 | 40,580 | +20,635 | 1.38 | 2.40 | +1.02 | buy |
| J. Goldman & Co LP | 2,700 | 23,100 | +20,400 | 0.01 | 0.06 | +0.05 | buy |
| ALGERT GLOBAL LLC | 0 | 19,650 | +19,650 | 0.00 | 0.04 | +0.04 | buy |
| Aquatic Capital Management LLC | 0 | 18,028 | +18,028 | 0.00 | 0.04 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 17,366 | +17,366 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 42,847 | 59,276 | +16,429 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,645 | 35,663 | +16,018 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 855,610 | 871,488 | +15,878 | 0.01 | 0.01 | -0.00 | buy |
| NORTHERN TRUST CORP | 319,780 | 335,550 | +15,770 | 0.01 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 10,446 | 23,990 | +13,544 | 0.01 | 0.01 | +0.00 | buy |
| Swiss National Bank | 57,800 | 70,400 | +12,600 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 19,649 | 31,342 | +11,693 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 1,193,679 | 1,204,927 | +11,248 | 1.03 | 0.64 | -0.39 | buy |
| HighVista Strategies LLC | 29,018 | 39,876 | +10,858 | 1.02 | 1.16 | +0.14 | buy |
| Aberdeen Group plc | 47,460 | 56,701 | +9,241 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,892 | 36,005 | +9,113 | 0.01 | 0.01 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 9,100 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 8,932 | +8,932 | 0.00 | 0.11 | +0.11 | buy |
| Edgestream Partners, L.P. | 2,829 | 11,724 | +8,895 | 0.01 | 0.04 | +0.03 | buy |
| UBS Group AG | 46,614 | 54,840 | +8,226 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 315,827 | 323,569 | +7,742 | 0.01 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 32,675 | 40,387 | +7,712 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 7,783 | 14,969 | +7,186 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 13,590 | 20,173 | +6,583 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 6,202 | +6,202 | 0.00 | 0.01 | +0.01 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 6,411 | 12,001 | +5,590 | 0.05 | 0.08 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 16,025 | 21,220 | +5,195 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 29,785 | 34,948 | +5,163 | 0.06 | 0.06 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,333 | 33,442 | +5,109 | 0.00 | 0.00 | -0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 5,080 | +5,080 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 5,000 | 10,000 | +5,000 | 0.83 | 1.48 | +0.65 | buy |
| Qube Research & Technologies Ltd | 0 | 4,944 | +4,944 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 4,805 | +4,805 | 0.00 | 0.07 | +0.07 | buy |
| Bank of New York Mellon Corp | 112,228 | 116,062 | +3,834 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 39,866 | 43,666 | +3,800 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 323 | 3,984 | +3,661 | 0.00 | 0.01 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 3,519 | +3,519 | 0.00 | 0.01 | +0.01 | buy |
| Headlands Technologies LLC | 0 | 3,514 | +3,514 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 7,385 | 10,793 | +3,408 | 0.00 | 0.00 | +0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 3,288 | +3,288 | 0.00 | 0.00 | +0.00 | buy |
| SYON CAPITAL LLC | 0 | 3,243 | +3,243 | 0.00 | 0.02 | +0.02 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 7,412 | 10,609 | +3,197 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 6,000 | 9,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 10,052 | 13,005 | +2,953 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 8,829 | 11,670 | +2,841 | 0.03 | 0.03 | -0.00 | buy |
| Diametric Capital, LP | 0 | 2,706 | +2,706 | 0.00 | 0.14 | +0.14 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 45,705 | 48,372 | +2,667 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,417 | 13,913 | +2,496 | 0.13 | 0.10 | -0.03 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 5,324 | 7,808 | +2,484 | 0.00 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 110,459 | 112,897 | +2,438 | 0.01 | 0.01 | -0.00 | buy |
| Nebula Research & Development LLC | 21,500 | 23,718 | +2,218 | 0.26 | 0.22 | -0.05 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 5,192 | 7,303 | +2,111 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 48,558 | 50,454 | +1,896 | 0.00 | 0.00 | -0.00 | buy |
| Arizona State Retirement System | 8,512 | 10,379 | +1,867 | 0.01 | 0.00 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 42,857 | 44,542 | +1,685 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 9,300 | 10,800 | +1,500 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 2,753 | 4,213 | +1,460 | 0.01 | 0.02 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,737 | 21,093 | +1,356 | 0.01 | 0.01 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,774 | 31,047 | +1,273 | 0.01 | 0.01 | -0.00 | buy |
| M&T BANK CORP | 7,281 | 8,473 | +1,192 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 1,156 | +1,156 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 10,477 | 11,617 | +1,140 | 0.03 | 0.02 | -0.01 | buy |
| GUGGENHEIM CAPITAL LLC | 10,010 | 11,050 | +1,040 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 180,352 | 181,206 | +854 | 0.02 | 0.01 | -0.00 | buy |