| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 19,991,024 | 17,991,024 | -2,000,000 | 30.56 | 26.79 | -3.77 | sell |
| FMR LLC | 9,654,352 | 9,654,326 | -26 | 0.06 | 0.05 | -0.01 | sell |
| Paradigm Biocapital Advisors LP | 5,000,000 | 5,363,379 | +363,379 | 17.90 | 14.61 | -3.29 | buy |
| VANGUARD GROUP INC | 4,133,625 | 4,499,864 | +366,239 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 3,624,981 | 3,851,577 | +226,596 | 0.01 | 0.01 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,979,235 | 2,619,977 | -359,258 | 6.54 | 5.71 | -0.83 | sell |
| Commodore Capital LP | 940,000 | 1,621,600 | +681,600 | 6.01 | 9.30 | +3.29 | buy |
| STATE STREET CORP | 1,243,099 | 1,489,680 | +246,581 | 0.01 | 0.00 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,697,267 | 1,447,267 | -1,250,000 | 28.71 | 13.33 | -15.38 | sell |
| Fairmount Funds Management LLC | 1,687,064 | 1,317,664 | -369,400 | 13.99 | 10.25 | -3.74 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,082,277 | 1,297,910 | +215,633 | 0.01 | 0.01 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,011,837 | 1,284,575 | +272,738 | 0.02 | 0.02 | +0.00 | buy |
| Woodline Partners LP | 1,193,679 | 1,204,927 | +11,248 | 1.03 | 0.64 | -0.39 | buy |
| Polar Capital Holdings Plc | 362,500 | 946,723 | +584,223 | 0.18 | 0.41 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 855,610 | 871,488 | +15,878 | 0.01 | 0.01 | -0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 863,957 | 793,416 | -70,541 | 0.76 | 0.51 | -0.25 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 280,000 | 680,000 | +400,000 | 0.05 | 0.09 | +0.04 | buy |
| Pictet Asset Management Holding SA | 621,133 | 641,781 | +20,648 | 0.07 | 0.05 | -0.02 | buy |
| Vestal Point Capital, LP | 0 | 600,000 | +600,000 | 0.00 | 2.78 | +2.78 | buy |
| Rock Springs Capital Management LP | 429,994 | 429,994 | 0 | 1.43 | 1.28 | -0.15 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 371,441 | 400,014 | +28,573 | 8.56 | 7.00 | -1.56 | buy |
| Candriam S.C.A. | 318,367 | 368,095 | +49,728 | 0.19 | 0.17 | -0.02 | buy |
| MARSHALL WACE, LLP | 141,704 | 361,040 | +219,336 | 0.02 | 0.04 | +0.02 | buy |
| NORTHERN TRUST CORP | 319,780 | 335,550 | +15,770 | 0.01 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 315,827 | 323,569 | +7,742 | 0.01 | 0.00 | -0.00 | buy |
| NORGES BANK | 274,644 | 318,739 | +44,095 | 0.00 | 0.00 | -0.00 | buy |
| SAMLYN CAPITAL, LLC | 281,233 | 310,037 | +28,804 | 0.46 | 0.39 | -0.08 | buy |
| First Turn Management, LLC | 359,114 | 309,521 | -49,593 | 5.82 | 4.34 | -1.48 | sell |
| FRED ALGER MANAGEMENT, LLC | 627,742 | 308,057 | -319,685 | 0.31 | 0.11 | -0.20 | sell |
| LORD, ABBETT & CO. LLC | 308,362 | 297,588 | -10,774 | 0.10 | 0.07 | -0.03 | sell |
| ArrowMark Colorado Holdings LLC | 295,152 | 295,350 | +198 | 0.39 | 0.31 | -0.08 | buy |
| GOLDMAN SACHS GROUP INC | 263,607 | 293,747 | +30,140 | 0.01 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 337,500 | 285,000 | -52,500 | 5.36 | 3.49 | -1.87 | sell |
| BANK OF AMERICA CORP /DE/ | 88,781 | 262,768 | +173,987 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 241,235 | +241,235 | 0.00 | 0.56 | +0.56 | buy |
| AMERIPRISE FINANCIAL INC | 65,831 | 237,556 | +171,725 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 471,717 | 222,284 | -249,433 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 262,388 | 213,882 | -48,506 | 0.06 | 0.04 | -0.02 | sell |
| Artia Global Partners LP | 15,437 | 204,045 | +188,608 | 0.45 | 6.44 | +5.99 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 186,385 | +186,385 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 180,352 | 181,206 | +854 | 0.02 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 245,581 | 176,912 | -68,669 | 0.03 | 0.02 | -0.02 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 313,004 | 170,844 | -142,160 | 0.12 | 0.05 | -0.07 | sell |
| FRANKLIN RESOURCES INC | 159,628 | 159,628 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 150,000 | 150,000 | 0 | 0.08 | 0.06 | -0.02 | hold |
| STEMPOINT CAPITAL LP | 0 | 145,234 | +145,234 | 0.00 | 2.85 | +2.85 | buy |
| TWO SIGMA ADVISERS, LP | 152,200 | 140,100 | -12,100 | 0.04 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 137,821 | 137,818 | -3 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 94,534 | 124,375 | +29,841 | 0.01 | 0.01 | +0.00 | buy |
| Twin Tree Management, LP | 4,667 | 120,352 | +115,685 | 0.01 | 0.23 | +0.22 | buy |
| Bank of New York Mellon Corp | 112,228 | 116,062 | +3,834 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 110,459 | 112,897 | +2,438 | 0.01 | 0.01 | -0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 0 | 111,065 | +111,065 | 0.00 | 0.40 | +0.40 | buy |
| CITADEL ADVISORS LLC | 242,558 | 110,095 | -132,463 | 0.03 | 0.01 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 258,037 | 105,397 | -152,640 | 0.01 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 74,357 | 104,357 | +30,000 | 0.63 | 0.62 | -0.01 | buy |
| Alyeska Investment Group, L.P. | 115,000 | 102,605 | -12,395 | 0.06 | 0.03 | -0.03 | sell |
| BARCLAYS PLC | 68,107 | 98,121 | +30,014 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 34,709 | 82,527 | +47,818 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 37,289 | 78,736 | +41,447 | 0.01 | 0.02 | +0.01 | buy |
| Nicholas Investment Partners, LP | 100,071 | 76,427 | -23,644 | 0.94 | 0.53 | -0.41 | sell |
| Rhenman & Partners Asset Management AB | 90,000 | 72,500 | -17,500 | 0.75 | 0.58 | -0.16 | sell |
| Swiss National Bank | 57,800 | 70,400 | +12,600 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 170,446 | 63,525 | -106,921 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 42,847 | 59,276 | +16,429 | 0.02 | 0.02 | +0.00 | buy |
| Opaleye Management Inc. | 64,000 | 58,500 | -5,500 | 1.09 | 0.80 | -0.29 | sell |
| Aberdeen Group plc | 47,460 | 56,701 | +9,241 | 0.01 | 0.01 | -0.00 | buy |
| UBS Group AG | 46,614 | 54,840 | +8,226 | 0.00 | 0.00 | -0.00 | buy |
| Ikarian Capital, LLC | 52,238 | 52,216 | -22 | 1.66 | 1.17 | -0.49 | sell |
| Trexquant Investment LP | 0 | 51,090 | +51,090 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 48,558 | 50,454 | +1,896 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 50,000 | 0 | 0.37 | 0.26 | -0.11 | hold |
| Walleye Capital LLC | 20,071 | 49,751 | +29,680 | 0.02 | 0.04 | +0.02 | buy |
| Atom Investors LP | 0 | 48,948 | +48,948 | 0.00 | 0.48 | +0.48 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 45,705 | 48,372 | +2,667 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 46,263 | +46,263 | 0.00 | 0.04 | +0.04 | buy |
| FIRST TRUST ADVISORS LP | 42,857 | 44,542 | +1,685 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,315 | +44,315 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 39,866 | 43,666 | +3,800 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 19,945 | 40,580 | +20,635 | 1.38 | 2.40 | +1.02 | buy |
| Legal & General Group Plc | 32,675 | 40,387 | +7,712 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 29,018 | 39,876 | +10,858 | 1.02 | 1.16 | +0.14 | buy |
| ALLIANCEBERNSTEIN L.P. | 39,120 | 39,620 | +500 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 26,892 | 36,005 | +9,113 | 0.01 | 0.01 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,645 | 35,663 | +16,018 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 29,785 | 34,948 | +5,163 | 0.06 | 0.06 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 28,333 | 33,442 | +5,109 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 19,649 | 31,342 | +11,693 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,774 | 31,047 | +1,273 | 0.01 | 0.01 | -0.00 | buy |
| Squarepoint Ops LLC | 33,466 | 30,706 | -2,760 | 0.01 | 0.01 | -0.01 | sell |
| TWINBEECH CAPITAL LP | 0 | 29,598 | +29,598 | 0.00 | 0.04 | +0.04 | buy |
| Polar Asset Management Partners Inc. | 68,780 | 25,580 | -43,200 | 0.17 | 0.03 | -0.14 | sell |
| Verition Fund Management LLC | 10,446 | 23,990 | +13,544 | 0.01 | 0.01 | +0.00 | buy |
| Nebula Research & Development LLC | 21,500 | 23,718 | +2,218 | 0.26 | 0.22 | -0.05 | buy |
| Parkman Healthcare Partners LLC | 23,400 | 23,588 | +188 | 0.31 | 0.25 | -0.06 | buy |
| J. Goldman & Co LP | 2,700 | 23,100 | +20,400 | 0.01 | 0.06 | +0.05 | buy |
| State of New Jersey Common Pension Fund D | 23,575 | 23,053 | -522 | 0.01 | 0.01 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 16,025 | 21,220 | +5,195 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,737 | 21,093 | +1,356 | 0.01 | 0.01 | -0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 21,516 | 20,522 | -994 | 0.10 | 0.07 | -0.03 | sell |