| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,991,024 | 17,248,450 | -742,574 | 23.84 | 22.24 | -1.60 | sell |
| FMR LLC | 10,013,237 | 10,852,884 | +839,647 | 0.05 | 0.06 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 5,269,433 | 5,269,433 | 0 | 13.48 | 14.19 | +0.71 | hold |
| VANGUARD GROUP INC | 4,605,007 | 5,244,271 | +639,264 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,085,795 | 4,805,261 | +719,466 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,300,865 | 2,461,823 | +160,958 | 0.03 | 0.04 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,674,009 | 2,205,251 | +531,242 | 0.01 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,810,420 | 2,146,938 | +336,518 | 0.02 | 0.02 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 1,246,456 | 1,880,057 | +633,601 | 1.33 | 1.94 | +0.61 | buy |
| STATE STREET CORP | 1,574,747 | 1,864,675 | +289,928 | 0.00 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,562,336 | 1,665,105 | +102,769 | 3.90 | 3.07 | -0.84 | buy |
| Polar Capital Holdings Plc | 1,022,225 | 1,536,859 | +514,634 | 0.43 | 0.71 | +0.28 | buy |
| JANUS HENDERSON GROUP PLC | 2,188,674 | 1,499,574 | -689,100 | 0.09 | 0.07 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 1,021,236 | 1,319,963 | +298,727 | 0.05 | 0.08 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,093,993 | 1,238,234 | +144,241 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 1,037,468 | +1,037,468 | 0.00 | 1.98 | +1.98 | buy |
| BRAIDWELL LP | 1,012,982 | 821,406 | -191,576 | 2.60 | 2.64 | +0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 49,968 | 785,445 | +735,477 | 0.00 | 0.02 | +0.02 | buy |
| Fairmount Funds Management LLC | 727,563 | 727,563 | 0 | 5.66 | 5.57 | -0.09 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 574,500 | 643,000 | +68,500 | 0.08 | 0.10 | +0.02 | buy |
| Woodline Partners LP | 1,069,520 | 610,459 | -459,061 | 0.44 | 0.24 | -0.20 | sell |
| GOLDMAN SACHS GROUP INC | 444,436 | 594,459 | +150,023 | 0.01 | 0.01 | +0.00 | buy |
| NORGES BANK | 0 | 574,242 | +574,242 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 527,050 | 564,298 | +37,248 | 0.01 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 1,400,000 | 550,000 | -850,000 | 5.91 | 3.68 | -2.23 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 216,556 | 483,504 | +266,948 | 0.13 | 0.33 | +0.20 | buy |
| Hood River Capital Management LLC | 0 | 475,440 | +475,440 | 0.00 | 0.52 | +0.52 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 404,553 | 453,311 | +48,758 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 33,757 | 439,300 | +405,543 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 160,134 | 411,354 | +251,220 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 381,496 | 410,450 | +28,954 | 0.00 | 0.01 | +0.00 | buy |
| UBS Group AG | 213,121 | 399,053 | +185,932 | 0.00 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 362,931 | 374,232 | +11,301 | 0.02 | 0.02 | +0.00 | buy |
| First Turn Management, LLC | 394,754 | 368,697 | -26,057 | 5.13 | 4.24 | -0.89 | sell |
| Candriam S.C.A. | 329,721 | 358,013 | +28,292 | 0.15 | 0.18 | +0.03 | buy |
| Pictet Asset Management Holding SA | 384,576 | 355,681 | -28,895 | 0.03 | 0.03 | +0.00 | sell |
| Affinity Asset Advisors, LLC | 384,417 | 322,633 | -61,784 | 3.09 | 2.33 | -0.76 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 372,300 | 311,430 | -60,870 | 4.66 | 4.53 | -0.13 | sell |
| Tri Locum Partners LP | 0 | 307,371 | +307,371 | 0.00 | 4.01 | +4.01 | buy |
| ArrowMark Colorado Holdings LLC | 362,585 | 296,029 | -66,556 | 0.58 | 0.66 | +0.07 | sell |
| LORD, ABBETT & CO. LLC | 0 | 281,215 | +281,215 | 0.00 | 0.09 | +0.09 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 270,470 | +270,470 | 0.00 | 0.29 | +0.29 | buy |
| MORGAN STANLEY | 275,110 | 267,389 | -7,721 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 30,226 | 195,156 | +164,930 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 161,186 | 180,369 | +19,183 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 137,945 | 174,066 | +36,121 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 134,742 | 172,527 | +37,785 | 0.01 | 0.02 | +0.01 | buy |
| Aberdeen Group plc | 76,688 | 165,177 | +88,489 | 0.01 | 0.03 | +0.02 | buy |
| Rhenman & Partners Asset Management AB | 52,500 | 163,350 | +110,850 | 0.50 | 1.54 | +1.03 | buy |
| Bank of New York Mellon Corp | 145,404 | 161,599 | +16,195 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 124,178 | 160,483 | +36,305 | 0.82 | 1.18 | +0.35 | buy |
| TD ASSET MANAGEMENT INC | 109,584 | 153,360 | +43,776 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 131,028 | 151,969 | +20,941 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 143,937 | 143,937 | 0 | 0.09 | 0.08 | -0.01 | hold |
| BARCLAYS PLC | 126,880 | 125,328 | -1,552 | 0.00 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 65,417 | 124,555 | +59,138 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 120,190 | 118,712 | -1,478 | 1.14 | 1.14 | -0.00 | sell |
| Nuveen, LLC | 91,633 | 107,620 | +15,987 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 106,424 | 100,706 | -5,718 | 0.00 | 0.00 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 88,503 | 92,021 | +3,518 | 0.03 | 0.04 | +0.01 | buy |
| Russell Investments Group, Ltd. | 92,484 | 91,195 | -1,289 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 0 | 88,392 | +88,392 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 71,700 | 83,039 | +11,339 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 81,866 | +81,866 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 77,200 | 78,900 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 64,462 | 78,275 | +13,813 | 0.00 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 93,294 | 73,287 | -20,007 | 1.98 | 1.90 | -0.08 | sell |
| Verition Fund Management LLC | 5,702 | 72,015 | +66,313 | 0.00 | 0.04 | +0.04 | buy |
| Burkehill Global Management, LP | 0 | 70,000 | +70,000 | 0.00 | 0.46 | +0.46 | buy |
| RHUMBLINE ADVISERS | 65,212 | 63,837 | -1,375 | 0.00 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 30,872 | 62,155 | +31,283 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 7,425 | 61,746 | +54,321 | 0.00 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 311 | 61,130 | +60,819 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 59,594 | +59,594 | 0.00 | 0.78 | +0.78 | buy |
| Ensign Peak Advisors, Inc | 64,379 | 54,202 | -10,177 | 0.01 | 0.01 | +0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 33,084 | 46,690 | +13,606 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 1,100,000 | 46,000 | -1,054,000 | 4.32 | 0.17 | -4.15 | sell |
| Rafferty Asset Management, LLC | 47,981 | 45,945 | -2,036 | 0.01 | 0.02 | +0.00 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 23,787 | 42,360 | +18,573 | 0.01 | 0.01 | +0.00 | buy |
| Legal & General Group Plc | 43,283 | 41,651 | -1,632 | 0.00 | 0.00 | +0.00 | sell |
| Granahan Investment Management, LLC | 0 | 40,211 | +40,211 | 0.00 | 0.17 | +0.17 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,886 | 38,284 | +398 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 33,007 | 37,003 | +3,996 | 0.02 | 0.02 | +0.00 | buy |
| TEMA ETFS LLC | 33,007 | 36,458 | +3,451 | 0.24 | 0.28 | +0.05 | buy |
| CITIGROUP INC | 35,160 | 35,831 | +671 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,967 | 32,547 | +1,580 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 28,062 | 32,460 | +4,398 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 22,520 | 29,940 | +7,420 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 3,516 | 27,955 | +24,439 | 0.00 | 0.04 | +0.03 | buy |
| MetLife Investment Management, LLC | 25,087 | 27,631 | +2,544 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 101,066 | 25,533 | -75,533 | 0.03 | 0.01 | -0.02 | sell |
| AQR CAPITAL MANAGEMENT LLC | 27,665 | 25,520 | -2,145 | 0.00 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 28,581 | 25,197 | -3,384 | 0.01 | 0.01 | +0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.19 | +0.19 | buy |
| MARSHALL WACE, LLP | 0 | 23,930 | +23,930 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 5,968 | 23,160 | +17,192 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 22,165 | +22,165 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 21,880 | -28,120 | 0.17 | 0.11 | -0.06 | sell |
| Legato Capital Management LLC | 12,651 | 21,732 | +9,081 | 0.12 | 0.19 | +0.07 | buy |
| SG Americas Securities, LLC | 18,836 | 20,326 | +1,490 | 0.01 | 0.00 | -0.00 | buy |