| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 1,246,456 | 1,880,057 | +633,601 | 1.33 | 1.94 | +0.61 | buy |
| Polar Capital Holdings Plc | 1,022,225 | 1,536,859 | +514,634 | 0.43 | 0.71 | +0.28 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,810,420 | 2,146,938 | +336,518 | 0.02 | 0.02 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,021,236 | 1,319,963 | +298,727 | 0.05 | 0.08 | +0.03 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 216,556 | 483,504 | +266,948 | 0.13 | 0.33 | +0.20 | buy |
| Rhenman & Partners Asset Management AB | 52,500 | 163,350 | +110,850 | 0.50 | 1.54 | +1.03 | buy |
| PERCEPTIVE ADVISORS LLC | 1,562,336 | 1,665,105 | +102,769 | 3.90 | 2.99 | -0.92 | buy |
| Aberdeen Group plc | 76,688 | 165,177 | +88,489 | 0.01 | 0.03 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 574,500 | 643,000 | +68,500 | 0.08 | 0.10 | +0.02 | buy |
| TD ASSET MANAGEMENT INC | 109,584 | 153,360 | +43,776 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 527,050 | 564,298 | +37,248 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 124,178 | 160,483 | +36,305 | 0.82 | 1.18 | +0.35 | buy |
| Candriam S.C.A. | 329,721 | 358,013 | +28,292 | 0.15 | 0.18 | +0.03 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 23,787 | 42,360 | +18,573 | 0.01 | 0.01 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 362,931 | 374,232 | +11,301 | 0.02 | 0.02 | +0.00 | buy |
| Legato Capital Management LLC | 12,651 | 21,732 | +9,081 | 0.12 | 0.19 | +0.07 | buy |
| PROFUND ADVISORS LLC | 10,687 | 17,536 | +6,849 | 0.03 | 0.05 | 0.00 | buy |
| NEOS Investment Management LLC | 33,007 | 37,003 | +3,996 | 0.02 | 0.02 | +0.00 | buy |
| STRS OHIO | 8,100 | 11,700 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 88,503 | 92,021 | +3,518 | 0.03 | 0.04 | +0.01 | buy |
| TEMA ETFS LLC | 33,007 | 36,458 | +3,451 | 0.24 | 0.28 | +0.05 | buy |
| ProShare Advisors LLC | 9,723 | 12,318 | +2,595 | 0.00 | 0.00 | 0.00 | buy |
| Virtus Investment Advisers, LLC | 1,461 | 2,538 | +1,077 | 0.04 | 0.07 | +0.03 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 10,769 | 10,932 | +163 | 0.02 | 0.02 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,686 | 11,769 | +83 | 0.08 | 0.09 | +0.01 | buy |
| J.Safra Asset Management Corp | 9 | 55 | +46 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 4,206 | 4,209 | +3 | 0.01 | 0.01 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,434 | 1,419 | -15 | 0.00 | 0.00 | +0.00 | sell |
| Parkman Healthcare Partners LLC | 120,190 | 118,712 | -1,478 | 1.14 | 1.14 | -0.00 | sell |
| CIBC WORLD MARKETS CORP | 5,295 | 3,312 | -1,983 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 47,981 | 45,945 | -2,036 | 0.01 | 0.02 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 11,842 | 6,842 | -5,000 | 0.10 | 0.05 | -0.05 | sell |
| HighVista Strategies LLC | 93,294 | 73,287 | -20,007 | 1.98 | 1.90 | -0.08 | sell |
| First Turn Management, LLC | 394,754 | 368,697 | -26,057 | 5.13 | 4.24 | -0.89 | sell |
| TANG CAPITAL MANAGEMENT LLC | 50,000 | 21,880 | -28,120 | 0.17 | 0.11 | -0.06 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 372,300 | 311,430 | -60,870 | 4.66 | 4.53 | -0.13 | sell |
| Affinity Asset Advisors, LLC | 384,417 | 322,633 | -61,784 | 3.09 | 2.33 | -0.76 | sell |
| ArrowMark Colorado Holdings LLC | 362,585 | 296,029 | -66,556 | 0.58 | 0.66 | +0.07 | sell |
| Alyeska Investment Group, L.P. | 101,066 | 25,533 | -75,533 | 0.03 | 0.01 | -0.02 | sell |
| BRAIDWELL LP | 1,012,982 | 821,406 | -191,576 | 2.60 | 2.64 | +0.04 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 17,991,024 | 17,248,450 | -742,574 | 23.75 | 22.16 | -1.59 | sell |
| Commodore Capital LP | 1,400,000 | 550,000 | -850,000 | 5.91 | 3.68 | -2.23 | sell |
| Vestal Point Capital, LP | 1,100,000 | 46,000 | -1,054,000 | 4.32 | 0.17 | -4.15 | sell |