| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 549,000 | 1,017,000 | +468,000 | 0.25 | 0.34 | +0.09 | buy |
| Sio Capital Management, LLC | 605,439 | 695,315 | +89,876 | 3.33 | 3.68 | +0.35 | buy |
| HighVista Strategies LLC | 131,304 | 184,774 | +53,470 | 1.39 | 1.35 | -0.04 | buy |
| China Universal Asset Management Co., Ltd. | 9,471 | 9,465 | -6 | 0.03 | 0.02 | -0.01 | sell |
| PDT Partners, LLC | 42,284 | 25,684 | -16,600 | 0.10 | 0.04 | -0.05 | sell |
| Sofinnova Investments, Inc. | 204,015 | 32,267 | -171,748 | 0.30 | 0.05 | -0.24 | sell |
| BVF INC/IL | 1,976,196 | 1,476,196 | -500,000 | 2.41 | 1.21 | -1.21 | sell |
| Nextech Invest, Ltd. | 4,055,861 | 3,553,585 | -502,276 | 10.93 | 5.39 | -5.55 | sell |