| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 7,236,454 | 10,416,609 | +3,180,155 | 1.57 | 2.17 | +0.61 | buy |
| BVF INC/IL | 2,739,595 | 4,661,194 | +1,921,599 | 0.95 | 2.10 | +1.15 | buy |
| FMR LLC | 2,768,696 | 3,977,208 | +1,208,512 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 768,638 | +768,638 | 0.00 | 0.23 | +0.23 | buy |
| Sio Capital Management, LLC | 0 | 535,741 | +535,741 | 0.00 | 3.06 | +3.06 | buy |
| 5AM Venture Management, LLC | 554,979 | 939,298 | +384,319 | 2.04 | 3.45 | +1.41 | buy |
| First Turn Management, LLC | 0 | 381,210 | +381,210 | 0.00 | 0.94 | +0.94 | buy |
| PERCEPTIVE ADVISORS LLC | 360,000 | 669,159 | +309,159 | 0.11 | 0.19 | +0.08 | buy |
| ExodusPoint Capital Management, LP | 0 | 272,150 | +272,150 | 0.00 | 0.06 | +0.06 | buy |
| Kynam Capital Management, LP | 340,190 | 515,190 | +175,000 | 0.53 | 0.94 | +0.41 | buy |
| Nicholas Investment Partners, LP | 0 | 152,968 | +152,968 | 0.00 | 0.26 | +0.26 | buy |
| VANGUARD GROUP INC | 758,967 | 899,800 | +140,833 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 333,469 | 416,808 | +83,339 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 0 | 59,576 | +59,576 | 0.00 | 0.02 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 54,400 | +54,400 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 41,742 | +41,742 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,537 | 152,212 | +41,675 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 28,300 | +28,300 | 0.00 | 0.13 | +0.13 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,031 | 32,149 | +28,118 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 265,354 | 292,234 | +26,880 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 16,887 | +16,887 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 16,789 | +16,789 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 15,159 | +15,159 | 0.00 | 0.01 | +0.01 | buy |
| FISHMAN JAY A LTD/MI | 0 | 15,000 | +15,000 | 0.00 | 0.03 | +0.03 | buy |
| UBS Group AG | 0 | 14,172 | +14,172 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 14,077 | +14,077 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 10,880 | 24,937 | +14,057 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 13,317 | +13,317 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 12,174 | +12,174 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 22,118 | 33,032 | +10,914 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 9,531 | 16,053 | +6,522 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 2,031 | 7,106 | +5,075 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 2,653 | 7,032 | +4,379 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 152,250 | 156,472 | +4,222 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 41,945 | 43,735 | +1,790 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 1,345 | +1,345 | 0.00 | 0.02 | +0.02 | buy |
| STRS OHIO | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,073 | 4,725 | +652 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 10,609 | 10,750 | +141 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 19 | 126 | +107 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 16 | 34 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1 | +1 | 0.00 | 0.00 | 0.00 | buy |
| Ameritas Investment Partners, Inc. | 940 | 940 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 7,702 | 7,702 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Auour Investments LLC | 85,020 | 85,020 | 0 | 0.45 | 0.51 | +0.07 | hold |
| Fairmount Funds Management LLC | 1,393,329 | 1,393,329 | 0 | 2.04 | 2.49 | +0.45 | hold |
| TCG Crossover Management, LLC | 1,989,103 | 1,989,103 | 0 | 3.06 | 2.58 | -0.48 | hold |
| Canaan Partners XI LLC | 4,409,991 | 4,409,991 | 0 | 76.34 | 79.77 | +3.44 | hold |
| GAMMA Investing LLC | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 814 | 814 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 1,265 | 1,265 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 203,709 | 203,709 | 0 | 0.03 | 0.03 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 6,951 | 6,892 | -59 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 6,223 | 6,013 | -210 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 21,332 | 20,998 | -334 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 102,436 | 101,788 | -648 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,302 | 1,406 | -896 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,004 | 0 | -1,004 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,445 | 424 | -1,021 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2,070 | 713 | -1,357 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 50,220 | 48,090 | -2,130 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 8,867 | 0 | -8,867 | 0.07 | 0.00 | -0.07 | sell |
| BARCLAYS PLC | 19,227 | 9,850 | -9,377 | 0.00 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 10,253 | 0 | -10,253 | 0.06 | 0.00 | -0.06 | sell |
| MARSHALL WACE, LLP | 30,001 | 19,643 | -10,358 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 10,500 | 0 | -10,500 | 0.00 | 0.00 | -0.00 | sell |
| Sepio Capital, LP | 10,625 | 0 | -10,625 | 0.01 | 0.00 | -0.01 | sell |
| JPMORGAN CHASE & CO | 401,706 | 380,597 | -21,109 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 22,164 | 0 | -22,164 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 48,170 | 501 | -47,669 | 0.18 | 0.00 | -0.18 | sell |
| EcoR1 Capital, LLC | 137,014 | 0 | -137,014 | 0.05 | 0.00 | -0.05 | sell |
| Frazier Life Sciences Management, L.P. | 1,026,420 | 832,220 | -194,200 | 0.76 | 0.58 | -0.18 | sell |