| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vestal Point Capital, LP | 990,000 | 2,879,829 | +1,889,829 | 0.82 | 1.91 | +1.10 | buy |
| Kynam Capital Management, LP | 530,478 | 2,406,067 | +1,875,589 | 0.49 | 1.91 | +1.43 | buy |
| Commodore Capital LP | 0 | 950,000 | +950,000 | 0.00 | 0.65 | +0.65 | buy |
| JANUS HENDERSON GROUP PLC | 1,746,320 | 2,693,237 | +946,917 | 0.01 | 0.01 | +0.00 | buy |
| TCG Crossover Management, LLC | 1,989,103 | 2,898,103 | +909,000 | 2.70 | 3.68 | +0.97 | buy |
| MARSHALL WACE, LLP | 54,077 | 380,700 | +326,623 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,470,086 | 1,752,831 | +282,745 | 0.42 | 0.39 | -0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 243,244 | +243,244 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 180,590 | +180,590 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 240,870 | 416,617 | +175,747 | 0.94 | 1.17 | +0.23 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,000,981 | 1,143,818 | +142,837 | 0.07 | 0.06 | -0.02 | buy |
| AXA S.A. | 0 | 128,189 | +128,189 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 354,012 | 459,113 | +105,101 | 0.01 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 0 | 100,108 | +100,108 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 315,141 | 404,165 | +89,024 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 62,980 | 140,742 | +77,762 | 0.01 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,318 | 68,950 | +64,632 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 244,245 | 301,801 | +57,556 | 0.01 | 0.01 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 46,371 | +46,371 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 42,174 | +42,174 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 55,587 | 96,282 | +40,695 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 12,300 | 50,100 | +37,800 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 12,783 | 49,600 | +36,817 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 34,813 | +34,813 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 30,235 | +30,235 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 111,107 | 141,241 | +30,134 | 0.02 | 0.04 | +0.02 | buy |
| Caligan Partners LP | 0 | 25,000 | +25,000 | 0.00 | 0.05 | +0.05 | buy |
| AlphaQuest LLC | 5,023 | 29,622 | +24,599 | 0.01 | 0.03 | +0.02 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 29,100 | 51,400 | +22,300 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 46,269 | 64,818 | +18,549 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 66,157 | 83,521 | +17,364 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 64,110 | 78,006 | +13,896 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 13,597 | +13,597 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 15,160 | 27,949 | +12,789 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 10,818 | +10,818 | 0.00 | 0.03 | +0.03 | buy |
| VANGUARD GROUP INC | 1,207,765 | 1,218,371 | +10,606 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 0 | 10,302 | +10,302 | 0.00 | 0.04 | +0.04 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 94,859 | 104,087 | +9,228 | 0.00 | 0.00 | -0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 9,047 | +9,047 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 20,700 | 29,400 | +8,700 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 4,586 | 11,781 | +7,195 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 407,573 | 413,988 | +6,415 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 9,671 | 15,120 | +5,449 | 0.00 | 0.00 | -0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 8,311 | 11,861 | +3,550 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 26,202 | 28,081 | +1,879 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 3,612 | 5,435 | +1,823 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 561 | 2,273 | +1,712 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,142 | 23,431 | +1,289 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 792 | +792 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,417 | 2,083 | +666 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 503 | +503 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 71 | 383 | +312 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 424 | 701 | +277 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,063 | 1,296 | +233 | 0.00 | 0.00 | -0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 23 | 149 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,686 | 1,693 | +7 | 0.00 | 0.00 | -0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 3,944,194 | 3,944,194 | 0 | 1.86 | 1.50 | -0.36 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,570 | 10,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,570 | 17,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 23,941 | 23,941 | 0 | 0.12 | 0.09 | -0.04 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,637,290 | 10,637,290 | 0 | 1.97 | 1.65 | -0.32 | hold |
| MetLife Investment Management, LLC | 12,207 | 12,207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 2,200 | 2,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.11 | 0.08 | -0.03 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 3.12 | 3.30 | +0.19 | hold |
| CoreCap Advisors, LLC | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,049 | 5,049 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alta Partners Management Company, L.P. | 4,080,296 | 4,080,296 | 0 | 89.47 | 90.83 | +1.36 | hold |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | 85,020 | 0 | 3.00 | 1.80 | -1.20 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 5 | 5 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 35,635 | 35,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 19 | 4 | -15 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 24 | 0 | -24 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 26 | 0 | -26 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 63 | 0 | -63 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 9,340 | 9,261 | -79 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,641 | 11,514 | -127 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 9,493 | 9,353 | -140 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 214 | 0 | -214 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 10,455 | 10,239 | -216 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 54,783 | 54,344 | -439 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 56,640 | 56,150 | -490 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 10,102 | 9,590 | -512 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 1,028 | 475 | -553 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 43,070 | 42,511 | -559 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 10,730 | 10,150 | -580 | 0.01 | 0.01 | -0.01 | sell |
| OPPENHEIMER & CO INC | 75,439 | 74,805 | -634 | 0.02 | 0.01 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 517,578 | 516,290 | -1,288 | 0.00 | 0.00 | -0.00 | sell |