| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | 12,198,625 | 0 | 3.29 | 4.95 | +1.66 | hold |
| FMR LLC | 12,563 | 7,747,648 | +7,735,085 | 0.00 | 0.02 | +0.02 | buy |
| Nextech Invest, Ltd. | 4,055,861 | 4,055,861 | 0 | 10.31 | 10.93 | +0.62 | hold |
| JANUS HENDERSON GROUP PLC | 2,935,442 | 3,890,589 | +955,147 | 0.03 | 0.07 | +0.04 | buy |
| Alta Partners Management Company, L.P. | 3,823,425 | 3,823,425 | 0 | 97.03 | 96.97 | -0.06 | hold |
| FARALLON CAPITAL MANAGEMENT LLC | 2,066,818 | 3,580,818 | +1,514,000 | 0.28 | 0.81 | +0.53 | buy |
| TCG Crossover Management, LLC | 2,898,103 | 3,248,980 | +350,877 | 2.52 | 3.56 | +1.04 | buy |
| Commodore Capital LP | 3,375,000 | 2,475,000 | -900,000 | 5.91 | 5.48 | -0.42 | sell |
| BlackRock, Inc. | 2,086,423 | 2,217,929 | +131,506 | 0.00 | 0.00 | +0.00 | buy |
| Paradigm Biocapital Advisors LP | 0 | 2,054,991 | +2,054,991 | 0.00 | 1.61 | +1.61 | buy |
| BVF INC/IL | 2,127,665 | 1,976,196 | -151,469 | 1.88 | 2.41 | +0.53 | sell |
| Caligan Partners LP | 944,257 | 1,276,968 | +332,711 | 2.27 | 3.46 | +1.19 | buy |
| STATE STREET CORP | 749,463 | 1,216,078 | +466,615 | 0.00 | 0.00 | +0.00 | buy |
| 5AM Venture Management, LLC | 1,029,298 | 1,029,298 | 0 | 8.51 | 10.94 | +2.44 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 14,432 | 986,061 | +971,629 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 210,000 | 850,000 | +640,000 | 0.37 | 1.68 | +1.31 | buy |
| BARCLAYS PLC | 76,309 | 833,399 | +757,090 | 0.00 | 0.01 | +0.01 | buy |
| Canaan Partners XI LLC | 3,374,329 | 750,000 | -2,624,329 | 64.85 | 37.76 | -27.09 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 657,756 | 658,482 | +726 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 632,432 | +632,432 | 0.00 | 0.02 | +0.02 | buy |
| Sio Capital Management, LLC | 526,002 | 605,439 | +79,437 | 2.29 | 3.34 | +1.05 | buy |
| GOLDMAN SACHS GROUP INC | 182,387 | 550,334 | +367,947 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 549,000 | +549,000 | 0.00 | 0.25 | +0.25 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 818,326 | 351,479 | -466,847 | 0.04 | 0.03 | -0.01 | sell |
| Woodline Partners LP | 0 | 301,040 | +301,040 | 0.00 | 0.04 | +0.04 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 221,177 | 273,274 | +52,097 | 0.15 | 0.24 | +0.09 | buy |
| Affinity Asset Advisors, LLC | 0 | 257,512 | +257,512 | 0.00 | 0.58 | +0.58 | buy |
| RAYMOND JAMES FINANCIAL INC | 170,032 | 247,098 | +77,066 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 114,388 | 221,581 | +107,193 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 200,956 | 218,508 | +17,552 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 38,310 | 209,922 | +171,612 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 204,015 | +204,015 | 0.00 | 0.39 | +0.39 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199,426 | 199,111 | -315 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 711,891 | 197,748 | -514,143 | 0.02 | 0.01 | -0.01 | sell |
| STEMPOINT CAPITAL LP | 0 | 193,177 | +193,177 | 0.00 | 1.42 | +1.42 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 120,278 | 190,039 | +69,761 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 46,870 | 188,010 | +141,140 | 0.02 | 0.11 | +0.09 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 129,753 | 162,204 | +32,451 | 0.01 | 0.03 | +0.01 | buy |
| Trexquant Investment LP | 0 | 147,317 | +147,317 | 0.00 | 0.04 | +0.04 | buy |
| AMERIPRISE FINANCIAL INC | 54,625 | 144,900 | +90,275 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 35,086 | 131,304 | +96,218 | 0.24 | 1.39 | +1.15 | buy |
| BNP Paribas Asset Management Holding S.A. | 129,779 | 128,860 | -919 | 0.00 | 0.01 | +0.00 | sell |
| MORGAN STANLEY | 118,898 | 120,485 | +1,587 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 129,435 | 109,052 | -20,383 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 107,023 | 101,618 | -5,405 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 95,640 | 91,826 | -3,814 | 0.00 | 0.00 | +0.00 | sell |
| OPPENHEIMER & CO INC | 84,726 | 84,192 | -534 | 0.03 | 0.04 | +0.01 | sell |
| XTX Topco Ltd | 30,414 | 83,896 | +53,482 | 0.02 | 0.06 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 79,592 | +79,592 | 0.00 | 0.02 | +0.02 | buy |
| Cinctive Capital Management LP | 0 | 78,018 | +78,018 | 0.00 | 0.20 | +0.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 104,305 | 77,169 | -27,136 | 0.00 | 0.00 | +0.00 | sell |
| Ensign Peak Advisors, Inc | 0 | 74,064 | +74,064 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 60,901 | 72,213 | +11,312 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12,996 | 70,422 | +57,426 | 0.00 | 0.00 | +0.00 | buy |
| Catalio Capital Management, LP | 0 | 67,285 | +67,285 | 0.00 | 0.54 | +0.54 | buy |
| JPMORGAN CHASE & CO | 71,175 | 66,789 | -4,386 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 58,856 | 61,561 | +2,705 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 2,425,000 | 54,000 | -2,371,000 | 2.34 | 0.06 | -2.28 | sell |
| Nuveen, LLC | 47,349 | 50,840 | +3,491 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 46,227 | 47,929 | +1,702 | 0.00 | 0.00 | +0.00 | buy |
| Arkadios Wealth Advisors | 0 | 47,567 | +47,567 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 48,644 | 47,025 | -1,619 | 0.02 | 0.03 | +0.01 | sell |
| ALPS ADVISORS INC | 43,827 | 43,856 | +29 | 0.01 | 0.01 | +0.00 | buy |
| PDT Partners, LLC | 42,284 | 42,284 | 0 | 0.07 | 0.10 | +0.02 | hold |
| Jump Financial, LLC | 0 | 41,375 | +41,375 | 0.00 | 0.02 | +0.02 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,357 | 40,224 | +31,867 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 38,790 | 39,660 | +870 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 874,192 | 38,850 | -835,342 | 0.04 | 0.00 | -0.03 | sell |
| Brevan Howard Capital Management LP | 0 | 38,606 | +38,606 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 29,887 | 38,358 | +8,471 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 15,455 | 34,856 | +19,401 | 0.00 | 0.01 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 39,023 | 33,258 | -5,765 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 31,990 | 31,990 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 28,631 | 29,423 | +792 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 28,800 | 28,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Eversept Partners, LP | 278,564 | 27,055 | -251,509 | 0.41 | 0.07 | -0.34 | sell |
| Swiss National Bank | 0 | 26,400 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 19,603 | 23,948 | +4,345 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.18 | 0.25 | +0.08 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18,542 | 20,522 | +1,980 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 16,377 | 20,495 | +4,118 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 54,424 | 20,494 | -33,930 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 18,715 | +18,715 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 18,203 | +18,203 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 700 | 18,100 | +17,400 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 16,284 | +16,284 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 15,656 | +15,656 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,135 | 15,543 | -39,592 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 15,396 | +15,396 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,790 | 15,230 | -3,560 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 12,908 | 14,626 | +1,718 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 28,900 | 14,300 | -14,600 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 42,791 | 14,066 | -28,725 | 0.01 | 0.01 | -0.01 | sell |
| MetLife Investment Management, LLC | 15,356 | 13,993 | -1,363 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 12,970 | 12,970 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 11,756 | 12,049 | +293 | 0.08 | 0.13 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 29,049 | 11,672 | -17,377 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JANE STREET GROUP, LLC | 0 | 10,169 | +10,169 | 0.00 | 0.00 | +0.00 | buy |