| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avidity Partners Management LP | 0 | 373,000 | +373,000 | 0.00 | 0.25 | +0.25 | buy |
| VANGUARD GROUP INC | 899,800 | 1,238,501 | +338,701 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 669,159 | 1,007,367 | +338,208 | 0.19 | 0.39 | +0.20 | buy |
| Ally Bridge Group (NY) LLC | 0 | 264,660 | +264,660 | 0.00 | 2.52 | +2.52 | buy |
| Ensign Peak Advisors, Inc | 0 | 190,557 | +190,557 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 149,350 | +149,350 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 24,937 | 170,283 | +145,346 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 416,808 | 522,674 | +105,866 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 14,077 | 114,874 | +100,797 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 88,656 | +88,656 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 292,234 | 368,484 | +76,250 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 535,741 | 600,294 | +64,553 | 3.06 | 3.62 | +0.56 | buy |
| MORGAN STANLEY | 0 | 64,531 | +64,531 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 515,190 | 566,715 | +51,525 | 0.94 | 0.95 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 42,223 | +42,223 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 0 | 40,998 | +40,998 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 38,065 | +38,065 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,212 | 169,945 | +17,733 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 17,570 | +17,570 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 33,032 | 49,517 | +16,485 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 16,078 | +16,078 | 0.00 | 0.09 | +0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 101,788 | 117,032 | +15,244 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 43,735 | 58,087 | +14,352 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 16,887 | 31,146 | +14,259 | 0.00 | 0.01 | +0.00 | buy |
| Parkwood LLC | 0 | 14,056 | +14,056 | 0.00 | 0.03 | +0.03 | buy |
| OPPENHEIMER & CO INC | 59,576 | 70,488 | +10,912 | 0.02 | 0.02 | +0.00 | buy |
| Mariner, LLC | 0 | 10,785 | +10,785 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 4,560 | +4,560 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 7,702 | 12,207 | +4,505 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,013 | 9,327 | +3,314 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 12,174 | 15,306 | +3,132 | 0.02 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 9,850 | 12,519 | +2,669 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 20,998 | 23,572 | +2,574 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,177 | +2,177 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 4,725 | 6,506 | +1,781 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 940 | 1,991 | +1,051 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,265 | 2,249 | +984 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,406 | 1,472 | +66 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 16 | 35 | +19 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1 | 10 | +9 | 0.00 | 0.00 | 0.00 | buy |
| Arax Advisory Partners | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 6 | +6 | 0.00 | 0.00 | 0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 34 | 40 | +6 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 768,638 | 768,638 | 0 | 0.23 | 0.24 | +0.01 | hold |
| BVF INC/IL | 4,661,194 | 4,661,194 | 0 | 2.10 | 2.09 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,416,609 | 10,416,609 | 0 | 2.17 | 2.20 | +0.03 | hold |
| Auour Investments LLC | 85,020 | 85,020 | 0 | 0.51 | 0.51 | -0.01 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 3.45 | 3.36 | -0.09 | hold |
| TCG Crossover Management, LLC | 1,989,103 | 1,989,103 | 0 | 2.58 | 3.31 | +0.74 | hold |
| Canaan Partners XI LLC | 4,409,991 | 4,409,991 | 0 | 79.77 | 85.38 | +5.61 | hold |
| Frazier Life Sciences Management, L.P. | 832,220 | 832,220 | 0 | 0.58 | 0.62 | +0.05 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 424 | 424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Avior Wealth Management, LLC | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 100 | 59 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 126 | 8 | -118 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 713 | 566 | -147 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 501 | 0 | -501 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 814 | 0 | -814 | 0.00 | 0.00 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 48,090 | 47,160 | -930 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 156,472 | 155,451 | -1,021 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 1,345 | 0 | -1,345 | 0.02 | 0.00 | -0.02 | sell |
| Jump Financial, LLC | 15,159 | 12,754 | -2,405 | 0.01 | 0.00 | -0.00 | sell |
| FISHMAN JAY A LTD/MI | 15,000 | 12,500 | -2,500 | 0.03 | 0.02 | -0.01 | sell |
| CITIGROUP INC | 7,106 | 4,433 | -2,673 | 0.00 | 0.00 | -0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 16,053 | 12,245 | -3,808 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 41,742 | 35,272 | -6,470 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 14,172 | 7,575 | -6,597 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 6,892 | 0 | -6,892 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 7,032 | 0 | -7,032 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 10,750 | 0 | -10,750 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 13,317 | 0 | -13,317 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 380,597 | 364,751 | -15,846 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 16,789 | 0 | -16,789 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 19,643 | 0 | -19,643 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 32,149 | 7,423 | -24,726 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 28,300 | 300 | -28,000 | 0.13 | 0.00 | -0.13 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 54,400 | 0 | -54,400 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 272,150 | 170,717 | -101,433 | 0.06 | 0.03 | -0.03 | sell |
| Nicholas Investment Partners, LP | 152,968 | 0 | -152,968 | 0.26 | 0.00 | -0.26 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 203,709 | 0 | -203,709 | 0.03 | 0.00 | -0.03 | sell |
| First Turn Management, LLC | 381,210 | 0 | -381,210 | 0.94 | 0.00 | -0.94 | sell |
| FMR LLC | 3,977,208 | 3,346,663 | -630,545 | 0.00 | 0.00 | -0.00 | sell |
| Fairmount Funds Management LLC | 1,393,329 | 0 | -1,393,329 | 2.49 | 0.00 | -2.49 | sell |