| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,637,290 | 12,198,625 | +1,561,335 | 1.65 | 1.97 | +0.31 | buy |
| Alta Partners Management Company, L.P. | 4,080,296 | 4,080,296 | 0 | 90.83 | 93.82 | +3.00 | hold |
| Nextech Invest, Ltd. | 4,055,861 | 4,055,861 | 0 | 8.77 | 7.35 | -1.42 | hold |
| BVF INC/IL | 3,944,194 | 3,944,194 | 0 | 1.50 | 1.35 | -0.15 | hold |
| Canaan Partners XI LLC | 4,144,590 | 3,608,109 | -536,481 | 58.09 | 20.10 | -37.98 | sell |
| Commodore Capital LP | 950,000 | 3,100,000 | +2,150,000 | 0.65 | 2.09 | +1.44 | buy |
| TCG Crossover Management, LLC | 2,898,103 | 2,898,103 | 0 | 3.68 | 3.17 | -0.51 | hold |
| JANUS HENDERSON GROUP PLC | 2,693,237 | 2,856,290 | +163,053 | 0.01 | 0.01 | -0.00 | buy |
| Vestal Point Capital, LP | 2,879,829 | 2,655,000 | -224,829 | 1.91 | 1.34 | -0.57 | sell |
| Kynam Capital Management, LP | 2,406,067 | 2,329,998 | -76,069 | 1.91 | 2.40 | +0.49 | sell |
| BlackRock, Inc. | 1,695,917 | 1,893,328 | +197,411 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,218,371 | 1,401,693 | +183,322 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,143,818 | 1,143,818 | 0 | 0.06 | 0.05 | -0.01 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 3.30 | 3.46 | +0.15 | hold |
| Sio Capital Management, LLC | 416,617 | 810,274 | +393,657 | 1.17 | 3.11 | +1.94 | buy |
| ORBIMED ADVISORS LLC | 1,752,831 | 804,603 | -948,228 | 0.39 | 0.19 | -0.20 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 243,244 | 583,386 | +340,142 | 0.01 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 516,290 | 567,126 | +50,836 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 380,700 | 428,108 | +47,408 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 413,988 | 418,984 | +4,996 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 404,165 | 407,464 | +3,299 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 301,801 | 395,299 | +93,498 | 0.01 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 180,590 | 378,402 | +197,812 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 83,521 | 372,967 | +289,446 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 140,742 | 370,408 | +229,666 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 49,600 | 224,700 | +175,100 | 0.00 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 96,282 | 216,136 | +119,854 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 216,447 | 205,308 | -11,139 | 0.00 | 0.00 | -0.00 | sell |
| Caligan Partners LP | 25,000 | 189,950 | +164,950 | 0.05 | 0.35 | +0.30 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 164,108 | 178,104 | +13,996 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 51,400 | 135,100 | +83,700 | 0.00 | 0.00 | +0.00 | buy |
| AXA S.A. | 128,189 | 128,400 | +211 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 91,844 | 122,036 | +30,192 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 64,818 | 105,825 | +41,007 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 78,006 | 105,595 | +27,589 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 104,087 | 103,078 | -1,009 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 85,490 | 102,917 | +17,427 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 100,108 | 100,108 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 68,950 | 97,736 | +28,786 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 50,100 | 87,000 | +36,900 | 0.00 | 0.00 | +0.00 | buy |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | 85,020 | 0 | 1.80 | 1.67 | -0.13 | hold |
| AMERIPRISE FINANCIAL INC | 0 | 80,602 | +80,602 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 49,998 | 80,441 | +30,443 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 58,712 | 76,449 | +17,737 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 74,805 | 74,033 | -772 | 0.01 | 0.01 | -0.00 | sell |
| AlphaQuest LLC | 29,622 | 73,073 | +43,451 | 0.03 | 0.07 | +0.04 | buy |
| Jump Financial, LLC | 27,949 | 71,119 | +43,170 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 30,235 | 67,442 | +37,207 | 0.00 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 54,344 | 63,187 | +8,843 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 42,511 | 61,555 | +19,044 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 34,813 | 58,168 | +23,355 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 41,083 | 54,039 | +12,956 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 48,644 | +48,644 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 46,286 | 46,268 | -18 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 0 | 44,681 | +44,681 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 56,150 | 44,190 | -11,960 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 43,310 | +43,310 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 34,712 | 41,681 | +6,969 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 42,174 | 40,939 | -1,235 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 28,081 | 40,685 | +12,604 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 37,782 | +37,782 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 46,371 | 36,594 | -9,777 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 17,570 | 35,640 | +18,070 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 34,601 | +34,601 | 0.00 | 0.01 | +0.01 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 34,115 | +34,115 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 31,408 | +31,408 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 23,431 | 28,854 | +5,423 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 28,729 | +28,729 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 28,712 | +28,712 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 12,093 | 26,265 | +14,172 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 23,941 | 24,962 | +1,021 | 0.09 | 0.09 | +0.00 | buy |
| Corton Capital Inc. | 0 | 24,346 | +24,346 | 0.00 | 0.27 | +0.27 | buy |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.08 | 0.07 | -0.01 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 13,597 | 19,919 | +6,322 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 18,512 | +18,512 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 16,213 | +16,213 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,353 | 15,457 | +6,104 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 12,207 | 14,631 | +2,424 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 11,781 | 13,744 | +1,963 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 16,979 | 13,300 | -3,679 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,514 | 13,182 | +1,668 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 10,302 | 12,350 | +2,048 | 0.04 | 0.04 | -0.00 | buy |
| FMR LLC | 1,707,148 | 12,202 | -1,694,946 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,022 | +12,022 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,150 | 10,681 | +531 | 0.01 | 0.01 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 10,239 | 9,975 | -264 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 15,507 | 9,497 | -6,010 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 10,818 | 9,103 | -1,715 | 0.03 | 0.03 | +0.00 | sell |
| US BANCORP \DE\ | 5,435 | 7,561 | +2,126 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,049 | 5,049 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asia (Singapore) Pte. Ltd. | 792 | 3,490 | +2,698 | 0.00 | 0.01 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,083 | 2,840 | +757 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 2,273 | 2,330 | +57 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 9,261 | 2,192 | -7,069 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,693 | 2,054 | +361 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 383 | 1,541 | +1,158 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,570 | 1,472 | -9,098 | 0.00 | 0.00 | -0.00 | sell |