| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | 12,198,625 | 0 | 4.95 | 3.39 | -1.56 | hold |
| FMR LLC | 7,747,648 | 8,920,513 | +1,172,865 | 0.02 | 0.01 | -0.00 | buy |
| Alta Partners Management Company, L.P. | 3,823,425 | 3,823,425 | 0 | 96.97 | 95.92 | -1.06 | hold |
| Nextech Invest, Ltd. | 4,055,861 | 3,553,585 | -502,276 | 10.93 | 5.39 | -5.55 | sell |
| TCG Crossover Management, LLC | 3,248,980 | 3,248,980 | 0 | 3.56 | 2.49 | -1.07 | hold |
| BlackRock, Inc. | 2,217,929 | 3,031,972 | +814,043 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 986,061 | 2,782,567 | +1,796,506 | 0.00 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 1,216,078 | 2,140,368 | +924,290 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 2,475,000 | 1,875,000 | -600,000 | 5.48 | 3.57 | -1.92 | sell |
| Paradigm Biocapital Advisors LP | 2,054,991 | 1,828,607 | -226,384 | 1.61 | 1.09 | -0.51 | sell |
| BVF INC/IL | 1,976,196 | 1,476,196 | -500,000 | 2.41 | 1.21 | -1.21 | sell |
| 5AM Venture Management, LLC | 1,029,298 | 1,029,298 | 0 | 10.94 | 11.42 | +0.48 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 549,000 | 1,017,000 | +468,000 | 0.25 | 0.34 | +0.09 | buy |
| Hood River Capital Management LLC | 0 | 1,016,775 | +1,016,775 | 0.00 | 0.24 | +0.24 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 658,482 | 970,734 | +312,252 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 1,276,968 | 806,986 | -469,982 | 3.46 | 1.24 | -2.22 | sell |
| Canaan Partners XI LLC | 750,000 | 750,000 | 0 | 37.76 | 18.82 | -18.94 | hold |
| Siren, L.L.C. | 0 | 725,000 | +725,000 | 0.00 | 0.47 | +0.47 | buy |
| Sio Capital Management, LLC | 605,439 | 695,315 | +89,876 | 3.34 | 3.81 | +0.46 | buy |
| STEMPOINT CAPITAL LP | 193,177 | 632,754 | +439,577 | 1.42 | 3.50 | +2.08 | buy |
| MARSHALL WACE, LLP | 197,748 | 583,133 | +385,385 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 550,334 | 463,477 | -86,857 | 0.00 | 0.00 | -0.00 | sell |
| JENNISON ASSOCIATES LLC | 632,432 | 450,964 | -181,468 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA INVESTMENTS, LP | 101,618 | 449,808 | +348,190 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 209,922 | 349,732 | +139,810 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 18,715 | 347,898 | +329,183 | 0.00 | 0.05 | +0.05 | buy |
| Woodline Partners LP | 301,040 | 320,040 | +19,000 | 0.04 | 0.03 | -0.01 | buy |
| NORTHERN TRUST CORP | 218,508 | 310,084 | +91,576 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 120,485 | 300,322 | +179,837 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 15,396 | 278,307 | +262,911 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 267,699 | +267,699 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 199,111 | 267,699 | +68,588 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 266,934 | +266,934 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 190,039 | 240,227 | +50,188 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 188,010 | 239,120 | +51,110 | 0.11 | 0.09 | -0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 91,826 | 217,078 | +125,252 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 257,512 | 200,012 | -57,500 | 0.58 | 0.31 | -0.27 | sell |
| FRANKLIN RESOURCES INC | 12,970 | 192,340 | +179,370 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 131,304 | 184,774 | +53,470 | 1.39 | 1.35 | -0.04 | buy |
| RAYMOND JAMES FINANCIAL INC | 247,098 | 180,881 | -66,217 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 66,789 | 178,263 | +111,474 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 221,581 | 177,672 | -43,909 | 0.01 | 0.00 | -0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 273,274 | 173,559 | -99,715 | 0.24 | 0.10 | -0.14 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 162,000 | +162,000 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 41,375 | 157,000 | +115,625 | 0.02 | 0.04 | +0.02 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 15,230 | 152,585 | +137,355 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 74,064 | 146,537 | +72,473 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 147,317 | 132,740 | -14,577 | 0.04 | 0.03 | -0.01 | sell |
| UBS Group AG | 61,561 | 129,945 | +68,384 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 128,860 | 123,420 | -5,440 | 0.01 | 0.00 | -0.00 | sell |
| LORD, ABBETT & CO. LLC | 0 | 121,833 | +121,833 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 72,213 | 103,720 | +31,507 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 70,422 | 102,443 | +32,021 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 102,000 | +102,000 | 0.00 | 0.06 | +0.06 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 162,204 | 89,205 | -72,999 | 0.03 | 0.01 | -0.02 | sell |
| OPPENHEIMER & CO INC | 84,192 | 83,783 | -409 | 0.04 | 0.03 | -0.01 | sell |
| XTX Topco Ltd | 83,896 | 81,320 | -2,576 | 0.06 | 0.03 | -0.02 | sell |
| Nuveen, LLC | 50,840 | 78,829 | +27,989 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 66,607 | +66,607 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 20,494 | 63,805 | +43,311 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,991 | 62,279 | +56,288 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 28,800 | 60,230 | +31,430 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 43,856 | 60,159 | +16,303 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 77,169 | 59,601 | -17,568 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 39,660 | 52,039 | +12,379 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Arkadios Wealth Advisors | 47,567 | 49,336 | +1,769 | 0.03 | 0.02 | -0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,990 | 48,420 | +16,430 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 33,258 | 46,697 | +13,439 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 47,025 | 44,878 | -2,147 | 0.03 | 0.02 | -0.00 | sell |
| Swiss National Bank | 26,400 | 44,700 | +18,300 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 40,224 | 44,327 | +4,103 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 14,066 | 41,026 | +26,960 | 0.01 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 34,856 | 38,702 | +3,846 | 0.01 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 20,495 | 36,935 | +16,440 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,672 | 33,561 | +21,889 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 204,015 | 32,267 | -171,748 | 0.39 | 0.06 | -0.34 | sell |
| Engineers Gate Manager LP | 0 | 31,958 | +31,958 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,423 | 29,853 | +430 | 0.00 | 0.00 | -0.00 | buy |
| Tidal Investments LLC | 0 | 29,519 | +29,519 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 29,519 | +29,519 | 0.00 | 0.03 | +0.03 | buy |
| SG Americas Securities, LLC | 7,215 | 29,444 | +22,229 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 42,284 | 25,684 | -16,600 | 0.10 | 0.04 | -0.05 | sell |
| Invesco Ltd. | 109,052 | 24,893 | -84,159 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,402 | 24,544 | +23,142 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 18,100 | 22,100 | +4,000 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 23,948 | 21,803 | -2,145 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 13,993 | 21,723 | +7,730 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,626 | 21,364 | +6,738 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 21,151 | +21,151 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.25 | 0.19 | -0.06 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 38,358 | 20,282 | -18,076 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 833,399 | 20,275 | -813,124 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 0 | 20,189 | +20,189 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,656 | 19,588 | +3,932 | 0.02 | 0.02 | -0.00 | buy |
| Legal & General Group Plc | 9,537 | 18,017 | +8,480 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 7,832 | 17,688 | +9,856 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 144,900 | 16,920 | -127,980 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 0 | 16,800 | +16,800 | 0.00 | 0.02 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 14,450 | +14,450 | 0.00 | 0.08 | +0.08 | buy |