| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 0 | 1,067,196 | +1,067,196 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 200,000 | +200,000 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 42,223 | 150,000 | +107,777 | 0.07 | 0.25 | +0.18 | buy |
| Walleye Capital LLC | 31,146 | 126,597 | +95,451 | 0.01 | 0.03 | +0.03 | buy |
| Polar Asset Management Partners Inc. | 0 | 88,100 | +88,100 | 0.00 | 0.05 | +0.05 | buy |
| NORTHERN TRUST CORP | 155,451 | 214,353 | +58,902 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 32,003 | +32,003 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 26,346 | +26,346 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 3,346,663 | 3,372,850 | +26,187 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 25,700 | +25,700 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 25,209 | +25,209 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 12,519 | 37,625 | +25,106 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 23,952 | +23,952 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 22,900 | +22,900 | 0.00 | 0.03 | +0.03 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 21,023 | +21,023 | 0.00 | 0.24 | +0.24 | buy |
| AlphaQuest LLC | 0 | 20,878 | +20,878 | 0.00 | 0.04 | +0.04 | buy |
| MARSHALL WACE, LLP | 0 | 19,614 | +19,614 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 368,484 | 384,732 | +16,248 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 14,184 | +14,184 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 13,211 | +13,211 | 0.00 | 0.00 | +0.00 | buy |
| Valence8 US LP | 0 | 13,188 | +13,188 | 0.00 | 0.14 | +0.14 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 12,988 | +12,988 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 12,647 | +12,647 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,472 | 12,936 | +11,464 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 10,504 | +10,504 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,433 | 14,667 | +10,234 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 9,907 | +9,907 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 149,350 | 158,187 | +8,837 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,249 | 9,340 | +7,091 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,238,501 | 1,245,408 | +6,907 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 70,488 | 76,806 | +6,318 | 0.02 | 0.03 | +0.01 | buy |
| Ally Bridge Group (NY) LLC | 264,660 | 270,075 | +5,415 | 2.52 | 3.40 | +0.88 | buy |
| BANK OF AMERICA CORP /DE/ | 49,517 | 54,353 | +4,836 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,508 | 11,109 | +4,601 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 64,531 | 68,916 | +4,385 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 35,272 | 39,176 | +3,904 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 364,751 | 368,647 | +3,896 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 169,945 | 173,737 | +3,792 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 7,575 | 10,964 | +3,389 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 9,327 | 12,443 | +3,116 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 23,572 | 25,175 | +1,603 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 848 | +848 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 522,674 | 523,190 | +516 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 566 | 930 | +364 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,560 | 4,642 | +82 | 0.04 | 0.05 | +0.02 | buy |
| GAMMA Investing LLC | 35 | 83 | +48 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 15 | +15 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 10 | 22 | +12 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 768,638 | 768,638 | 0 | 0.24 | 0.33 | +0.09 | hold |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BVF INC/IL | 4,661,194 | 4,661,194 | 0 | 2.09 | 3.21 | +1.12 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,570 | 17,570 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 16,078 | 16,078 | 0 | 0.09 | 0.13 | +0.04 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,416,609 | 10,416,609 | 0 | 2.20 | 2.82 | +0.62 | hold |
| MetLife Investment Management, LLC | 12,207 | 12,207 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 7 | 7 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 8 | 8 | 0 | 0.00 | 0.00 | +0.00 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 3.36 | 4.56 | +1.20 | hold |
| TCG Crossover Management, LLC | 1,989,103 | 1,989,103 | 0 | 3.31 | 3.96 | +0.65 | hold |
| Canaan Partners XI LLC | 4,409,991 | 4,409,991 | 0 | 85.38 | 87.81 | +2.43 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 424 | 424 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 59 | 0 | -59 | 0.00 | 0.00 | 0.00 | sell |
| Corebridge Financial, Inc. | 10,931 | 10,864 | -67 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 6,506 | 6,257 | -249 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,177 | 1,211 | -966 | 0.00 | 0.00 | +0.00 | sell |
| Mariner, LLC | 10,785 | 9,269 | -1,516 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 38,065 | 35,566 | -2,499 | 0.00 | 0.00 | +0.00 | sell |
| EXCHANGE TRADED CONCEPTS, LLC | 12,245 | 8,311 | -3,934 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 40,998 | 31,003 | -9,995 | 0.00 | 0.00 | +0.00 | sell |
| FISHMAN JAY A LTD/MI | 12,500 | 0 | -12,500 | 0.02 | 0.00 | -0.02 | sell |
| Jump Financial, LLC | 12,754 | 0 | -12,754 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 14,056 | 0 | -14,056 | 0.03 | 0.00 | -0.03 | sell |
| Bank of New York Mellon Corp | 58,087 | 42,786 | -15,301 | 0.00 | 0.00 | +0.00 | sell |
| PDT Partners, LLC | 15,306 | 0 | -15,306 | 0.02 | 0.00 | -0.02 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 47,160 | 30,080 | -17,080 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 114,874 | 89,081 | -25,793 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 117,032 | 90,825 | -26,207 | 0.00 | 0.00 | +0.00 | sell |
| Woodline Partners LP | 88,656 | 55,866 | -32,790 | 0.01 | 0.01 | -0.00 | sell |
| Auour Investments LLC | 85,020 | 21,020 | -64,000 | 0.51 | 0.13 | -0.38 | sell |
| Ensign Peak Advisors, Inc | 190,557 | 115,616 | -74,941 | 0.01 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 566,715 | 467,947 | -98,768 | 0.95 | 0.85 | -0.10 | sell |
| Frazier Life Sciences Management, L.P. | 832,220 | 731,020 | -101,200 | 0.62 | 0.69 | +0.07 | sell |
| AMERICAN CENTURY COMPANIES INC | 170,283 | 42,999 | -127,284 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 170,717 | 0 | -170,717 | 0.03 | 0.00 | -0.03 | sell |
| Sio Capital Management, LLC | 600,294 | 400,870 | -199,424 | 3.62 | 4.22 | +0.60 | sell |
| Avidity Partners Management LP | 373,000 | 0 | -373,000 | 0.25 | 0.00 | -0.25 | sell |
| PERCEPTIVE ADVISORS LLC | 1,007,367 | 511,226 | -496,141 | 0.39 | 0.26 | -0.13 | sell |