| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | 12,198,625 | 0 | 1.97 | 2.10 | +0.14 | hold |
| Alta Partners Management Company, L.P. | 4,080,296 | 4,080,296 | 0 | 93.82 | 95.15 | +1.32 | hold |
| Nextech Invest, Ltd. | 4,055,861 | 4,055,861 | 0 | 7.35 | 8.64 | +1.29 | hold |
| BVF INC/IL | 3,944,194 | 3,649,794 | -294,400 | 1.35 | 2.07 | +0.72 | sell |
| Canaan Partners XI LLC | 3,608,109 | 3,608,109 | 0 | 20.10 | 49.07 | +28.97 | hold |
| Commodore Capital LP | 3,100,000 | 3,375,000 | +275,000 | 2.09 | 2.30 | +0.21 | buy |
| TCG Crossover Management, LLC | 2,898,103 | 2,898,103 | 0 | 3.17 | 1.99 | -1.17 | hold |
| JANUS HENDERSON GROUP PLC | 2,856,290 | 2,874,804 | +18,514 | 0.01 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 2,655,000 | 2,425,000 | -230,000 | 1.34 | 1.54 | +0.20 | sell |
| Kynam Capital Management, LP | 2,329,998 | 2,329,998 | 0 | 2.40 | 2.43 | +0.03 | hold |
| BlackRock, Inc. | 1,893,328 | 1,869,474 | -23,854 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 1,401,693 | 1,520,185 | +118,492 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,143,818 | 1,143,818 | 0 | 0.05 | 0.09 | +0.04 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 3.46 | 4.81 | +1.36 | hold |
| BALYASNY ASSET MANAGEMENT L.P. | 583,386 | 846,585 | +263,199 | 0.01 | 0.02 | +0.01 | buy |
| Caligan Partners LP | 189,950 | 696,825 | +506,875 | 0.35 | 1.35 | +1.00 | buy |
| MARSHALL WACE, LLP | 428,108 | 602,015 | +173,907 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 567,126 | 597,454 | +30,328 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 810,274 | 514,947 | -295,327 | 3.11 | 1.82 | -1.29 | sell |
| STATE STREET CORP | 418,984 | 428,472 | +9,488 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 378,402 | 322,143 | -56,259 | 0.00 | 0.00 | +0.00 | sell |
| Walleye Capital LLC | 370,408 | 297,808 | -72,600 | 0.03 | 0.03 | +0.00 | sell |
| Point72 Asset Management, L.P. | 224,700 | 282,032 | +57,332 | 0.01 | 0.01 | +0.00 | buy |
| Eversept Partners, LP | 0 | 272,706 | +272,706 | 0.00 | 0.29 | +0.29 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 395,299 | 251,562 | -143,737 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 205,308 | 208,486 | +3,178 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,104 | 201,587 | +23,483 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 105,825 | 199,438 | +93,613 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 186,670 | +186,670 | 0.00 | 0.07 | +0.07 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 135,100 | 170,100 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 407,464 | 144,016 | -263,448 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 372,967 | 134,319 | -238,648 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 97,736 | 128,881 | +31,145 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 63,187 | 126,374 | +63,187 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 87,000 | 113,200 | +26,200 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 216,136 | 111,293 | -104,843 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 105,595 | 100,150 | -5,445 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 80,602 | 87,107 | +6,505 | 0.00 | 0.00 | +0.00 | buy |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | 85,020 | 0 | 1.67 | 2.42 | +0.75 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 103,078 | 82,871 | -20,207 | 0.00 | 0.00 | +0.00 | sell |
| OPPENHEIMER & CO INC | 74,033 | 82,238 | +8,205 | 0.01 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 80,441 | 80,441 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JPMORGAN CHASE & CO | 102,917 | 74,229 | -28,688 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 24,962 | 65,812 | +40,850 | 0.09 | 0.23 | +0.14 | buy |
| Jump Financial, LLC | 71,119 | 62,000 | -9,119 | 0.01 | 0.01 | +0.00 | sell |
| UBS Group AG | 46,268 | 59,144 | +12,876 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 54,039 | 57,162 | +3,123 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 61,555 | 57,126 | -4,429 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 48,644 | 48,644 | 0 | 0.01 | 0.01 | +0.00 | hold |
| JANE STREET GROUP, LLC | 58,168 | 44,680 | -13,488 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 43,310 | 43,310 | 0 | 0.02 | 0.04 | +0.01 | hold |
| RHUMBLINE ADVISERS | 40,685 | 40,636 | -49 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 41,681 | 39,679 | -2,002 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 122,036 | 39,310 | -82,726 | 0.01 | 0.01 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 28,854 | 38,412 | +9,558 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 34,601 | 33,700 | -901 | 0.01 | 0.02 | +0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 35,640 | 33,260 | -2,380 | 0.00 | 0.00 | +0.00 | sell |
| Brevan Howard Capital Management LP | 36,594 | 31,101 | -5,493 | 0.00 | 0.01 | +0.00 | sell |
| AlphaQuest LLC | 73,073 | 30,060 | -43,013 | 0.07 | 0.03 | -0.04 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 76,449 | 29,648 | -46,801 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 28,712 | 28,069 | -643 | 0.00 | 0.00 | +0.00 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 18,512 | 24,962 | +6,450 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 28,729 | 24,700 | -4,029 | 0.00 | 0.00 | +0.00 | sell |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.07 | 0.10 | +0.03 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 44,190 | 18,790 | -25,400 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 15,457 | 18,470 | +3,013 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 44,681 | 15,758 | -28,923 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 0 | 15,510 | +15,510 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,300 | 15,483 | +2,183 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,631 | 14,631 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,022 | 12,801 | +779 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 9,975 | 12,741 | +2,766 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,202 | 12,529 | +327 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 31,408 | 12,214 | -19,194 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 19,919 | 11,402 | -8,517 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,182 | 11,317 | -1,865 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 9,103 | 11,015 | +1,912 | 0.03 | 0.04 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 26,265 | 10,761 | -15,504 | 0.00 | 0.00 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SG Americas Securities, LLC | 0 | 9,542 | +9,542 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 10,681 | 9,342 | -1,339 | 0.01 | 0.01 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,049 | 6,440 | +1,391 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,192 | 2,192 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FEDERATED HERMES, INC. | 314 | 2,155 | +1,841 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,054 | 2,060 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 9,497 | 1,707 | -7,790 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 650 | 1,662 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,541 | 1,529 | -12 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,472 | 1,473 | +1 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,296 | 1,147 | -149 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,840 | 874 | -1,966 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 819 | 819 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 701 | 701 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 0 | 368 | +368 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 215 | 311 | +96 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 173 | 173 | 0 | 0.00 | 0.00 | -0.00 | hold |
| True Wealth Design, LLC | 142 | 142 | 0 | 0.00 | 0.00 | +0.00 | hold |