| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 0 | 340,190 | +340,190 | 0.00 | 0.53 | +0.53 | buy |
| 5AM Venture Management, LLC | 411,450 | 554,979 | +143,529 | 1.63 | 2.04 | +0.41 | buy |
| EcoR1 Capital, LLC | 0 | 137,014 | +137,014 | 0.00 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 150,468 | 203,709 | +53,241 | 0.03 | 0.03 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 30,001 | +30,001 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 732,584 | 758,967 | +26,383 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 314,478 | 333,469 | +18,991 | 0.00 | 0.00 | -0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 32,730 | 50,220 | +17,490 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 2,506 | 19,227 | +16,721 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 10,880 | +10,880 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 141,599 | 152,250 | +10,651 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 10,607 | +10,607 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 8,867 | +8,867 | 0.00 | 0.07 | +0.07 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 94,112 | 102,436 | +8,324 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 259,458 | 265,354 | +5,896 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 397,618 | 401,706 | +4,088 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 2,653 | +2,653 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 7,114 | 9,531 | +2,417 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19 | 2,031 | +2,012 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 154 | 2,070 | +1,916 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,230 | 4,073 | +843 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,214 | 110,537 | +323 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 858 | 1,004 | +146 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 41,870 | 41,945 | +75 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 940 | 940 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BVF INC/IL | 2,739,595 | 2,739,595 | 0 | 1.02 | 0.95 | -0.07 | hold |
| PERCEPTIVE ADVISORS LLC | 360,000 | 360,000 | 0 | 0.17 | 0.11 | -0.06 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 7,236,454 | 7,236,454 | 0 | 1.96 | 1.57 | -0.40 | hold |
| MetLife Investment Management, LLC | 7,702 | 7,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 19 | 19 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sepio Capital, LP | 10,625 | 10,625 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ikarian Capital, LLC | 48,170 | 48,170 | 0 | 0.25 | 0.18 | -0.06 | hold |
| Auour Investments LLC | 85,020 | 85,020 | 0 | 0.51 | 0.45 | -0.06 | hold |
| Fairmount Funds Management LLC | 1,393,329 | 1,393,329 | 0 | 2.31 | 2.04 | -0.27 | hold |
| TCG Crossover Management, LLC | 1,989,103 | 1,989,103 | 0 | 4.03 | 3.06 | -0.98 | hold |
| Canaan Partners XI LLC | 4,409,991 | 4,409,991 | 0 | 53.26 | 76.34 | +23.07 | hold |
| DIMENSIONAL FUND ADVISORS LP | 10,609 | 10,609 | 0 | 0.00 | 0.00 | -0.00 | hold |
| METROPOLITAN LIFE INSURANCE CO/NY | 814 | 814 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 1,265 | 1,265 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DEUTSCHE BANK AG\ | 6,223 | 6,223 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,046 | 4,031 | -15 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 6,980 | 6,951 | -29 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 22,164 | 22,118 | -46 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 1,571 | 1,445 | -126 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 21,461 | 21,332 | -129 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 3,086 | 2,302 | -784 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 1,028,013 | 1,026,420 | -1,593 | 0.94 | 0.76 | -0.18 | sell |
| SIMPLEX TRADING, LLC | 2,009 | 0 | -2,009 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 24,296 | 22,164 | -2,132 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 14,500 | 10,500 | -4,000 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 5,310 | 0 | -5,310 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 11,009 | 0 | -11,009 | 0.08 | 0.00 | -0.08 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 11,872 | 0 | -11,872 | 0.00 | 0.00 | -0.00 | sell |
| Parkwood LLC | 16,967 | 0 | -16,967 | 0.04 | 0.00 | -0.04 | sell |
| Logos Global Management LP | 31,872 | 0 | -31,872 | 0.06 | 0.00 | -0.06 | sell |
| Artia Global Partners LP | 45,253 | 10,253 | -35,000 | 0.26 | 0.06 | -0.20 | sell |
| Woodline Partners LP | 410,435 | 0 | -410,435 | 0.07 | 0.00 | -0.07 | sell |
| FMR LLC | 3,898,827 | 2,768,696 | -1,130,131 | 0.00 | 0.00 | -0.00 | sell |