| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,000,981 | +1,000,981 | 0.00 | 0.07 | +0.07 | buy |
| Vestal Point Capital, LP | 0 | 990,000 | +990,000 | 0.00 | 0.82 | +0.82 | buy |
| ORBIMED ADVISORS LLC | 768,638 | 1,470,086 | +701,448 | 0.33 | 0.42 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 1,067,196 | 1,746,320 | +679,124 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 354,012 | +354,012 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 10,504 | 315,141 | +304,637 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 244,245 | +244,245 | 0.00 | 0.01 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,416,609 | 10,637,290 | +220,681 | 2.82 | 1.97 | -0.86 | buy |
| BlackRock, Inc. | 1,516,172 | 1,718,504 | +202,332 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 109,748 | +109,748 | 0.00 | 0.02 | +0.02 | buy |
| Nantahala Capital Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.10 | +0.10 | buy |
| Kynam Capital Management, LP | 467,947 | 530,478 | +62,531 | 0.85 | 0.49 | -0.37 | buy |
| Ikarian Capital, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.24 | +0.24 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 39,093 | +39,093 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 10,964 | 47,851 | +36,887 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 19,614 | 54,077 | +34,463 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 23,952 | 55,587 | +31,635 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 35,566 | 65,039 | +29,473 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 29,100 | +29,100 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 9,907 | 37,981 | +28,074 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 30,080 | 56,640 | +26,560 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 88,100 | 111,107 | +23,007 | 0.05 | 0.02 | -0.03 | buy |
| STATE STREET CORP | 384,732 | 407,573 | +22,841 | 0.00 | 0.00 | -0.00 | buy |
| PDT Partners, LLC | 0 | 20,359 | +20,359 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 18,216 | +18,216 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 18,209 | +18,209 | 0.00 | 0.11 | +0.11 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 17,560 | +17,560 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 15,160 | +15,160 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 12,783 | +12,783 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 12,300 | +12,300 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 54,353 | 66,157 | +11,804 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 10,730 | +10,730 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 8 | 10,455 | +10,447 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 25,209 | 35,635 | +10,426 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 214,353 | 222,764 | +8,411 | 0.00 | 0.00 | -0.00 | buy |
| HighVista Strategies LLC | 16,078 | 23,941 | +7,863 | 0.13 | 0.12 | -0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 39,176 | 46,269 | +7,093 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 12,443 | 18,909 | +6,466 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 37,625 | 43,070 | +5,445 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 4,586 | +4,586 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,318 | +4,318 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 90,825 | 94,859 | +4,034 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 0 | 3,612 | +3,612 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,257 | 9,493 | +3,236 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 42,786 | 45,007 | +2,221 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 14,667 | 16,803 | +2,136 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,686 | +1,686 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 25,175 | 26,202 | +1,027 | 0.00 | 0.00 | -0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 561 | +561 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,109 | 11,641 | +532 | 0.00 | 0.00 | -0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 214 | +214 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,211 | 1,417 | +206 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 12,647 | 12,751 | +104 | 0.00 | 0.00 | -0.00 | buy |
| FEDERATED HERMES, INC. | 930 | 1,028 | +98 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 22 | 71 | +49 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 4,642 | 4,686 | +44 | 0.05 | 0.03 | -0.02 | buy |
| SIGNATUREFD, LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 17,570 | 17,570 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 200,000 | 200,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EXCHANGE TRADED CONCEPTS, LLC | 8,311 | 8,311 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 12,207 | 12,207 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.13 | 0.11 | -0.02 | hold |
| 5AM Venture Management, LLC | 939,298 | 939,298 | 0 | 4.56 | 3.12 | -1.45 | hold |
| TCG Crossover Management, LLC | 1,989,103 | 1,989,103 | 0 | 3.96 | 2.70 | -1.26 | hold |
| Covestor Ltd | 6 | 6 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Legal & General Group Plc | 9,340 | 9,340 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 700 | 700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 424 | 424 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 15 | 5 | -10 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 40 | 23 | -17 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 83 | 26 | -57 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 400 | 0 | -400 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 10,864 | 10,102 | -762 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 14,184 | 13,368 | -816 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 848 | 0 | -848 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 76,806 | 75,439 | -1,367 | 0.03 | 0.02 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,936 | 10,570 | -2,366 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 173,737 | 170,600 | -3,137 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 13,211 | 9,671 | -3,540 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 25,700 | 20,700 | -5,000 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 523,190 | 517,578 | -5,612 | 0.00 | 0.00 | -0.00 | sell |
| Mariner, LLC | 9,269 | 0 | -9,269 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 26,346 | 15,577 | -10,769 | 0.01 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 12,988 | 0 | -12,988 | 0.00 | 0.00 | -0.00 | sell |
| Valence8 US LP | 13,188 | 0 | -13,188 | 0.14 | 0.00 | -0.14 | sell |
| AlphaQuest LLC | 20,878 | 5,023 | -15,855 | 0.04 | 0.01 | -0.03 | sell |
| AMERICAN CENTURY COMPANIES INC | 42,999 | 22,142 | -20,857 | 0.00 | 0.00 | -0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 21,023 | 0 | -21,023 | 0.24 | 0.00 | -0.24 | sell |
| Cinctive Capital Management LP | 22,900 | 0 | -22,900 | 0.03 | 0.00 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 89,081 | 64,110 | -24,971 | 0.00 | 0.00 | -0.00 | sell |