| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ORBIMED ADVISORS LLC | 768,638 | 1,470,086 | +701,448 | 0.33 | 0.42 | +0.09 | buy |
| JANUS HENDERSON GROUP PLC | 1,067,196 | 1,746,320 | +679,124 | 0.01 | 0.01 | 0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,416,609 | 10,637,290 | +220,681 | 2.82 | 1.97 | -0.86 | buy |
| Kynam Capital Management, LP | 467,947 | 530,478 | +62,531 | 0.85 | 0.49 | -0.37 | buy |
| Polar Asset Management Partners Inc. | 88,100 | 111,107 | +23,007 | 0.04 | 0.02 | -0.03 | buy |
| HighVista Strategies LLC | 16,078 | 23,941 | +7,863 | 0.13 | 0.12 | -0.01 | buy |
| VIRTUS ADVISERS, LLC | 4,642 | 4,686 | +44 | 0.05 | 0.03 | -0.02 | buy |
| OPPENHEIMER & CO INC | 76,806 | 75,439 | -1,367 | 0.03 | 0.02 | -0.01 | sell |
| Ally Bridge Group (NY) LLC | 270,075 | 175,063 | -95,012 | 3.40 | 2.09 | -1.31 | sell |
| Sio Capital Management, LLC | 400,870 | 240,870 | -160,000 | 3.74 | 0.94 | -2.80 | sell |
| Canaan Partners XI LLC | 4,409,991 | 4,179,857 | -230,134 | 87.81 | 75.17 | -12.63 | sell |
| BVF INC/IL | 4,661,194 | 3,944,194 | -717,000 | 3.21 | 1.86 | -1.35 | sell |