| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | 12,198,625 | 0 | 2.10 | 3.29 | +1.18 | hold |
| Nextech Invest, Ltd. | 4,055,861 | 4,055,861 | 0 | 8.64 | 10.31 | +1.67 | hold |
| Alta Partners Management Company, L.P. | 4,080,296 | 3,823,425 | -256,871 | 95.15 | 97.03 | +1.88 | sell |
| Commodore Capital LP | 3,375,000 | 3,375,000 | 0 | 2.30 | 5.91 | +3.60 | hold |
| Canaan Partners XI LLC | 3,608,109 | 3,374,329 | -233,780 | 49.07 | 64.85 | +15.78 | sell |
| JANUS HENDERSON GROUP PLC | 2,874,804 | 2,935,442 | +60,638 | 0.02 | 0.03 | +0.02 | buy |
| TCG Crossover Management, LLC | 2,898,103 | 2,898,103 | 0 | 1.99 | 2.52 | +0.53 | hold |
| Vestal Point Capital, LP | 2,425,000 | 2,425,000 | 0 | 1.54 | 2.34 | +0.80 | hold |
| BVF INC/IL | 3,649,794 | 2,127,665 | -1,522,129 | 2.07 | 1.88 | -0.19 | sell |
| BlackRock, Inc. | 1,869,474 | 2,086,423 | +216,949 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 1,143,818 | 2,066,818 | +923,000 | 0.09 | 0.28 | +0.19 | buy |
| VANGUARD GROUP INC | 1,520,185 | 1,572,785 | +52,600 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 2,329,998 | 1,564,492 | -765,506 | 2.43 | 2.68 | +0.25 | sell |
| 5AM Venture Management, LLC | 939,298 | 1,029,298 | +90,000 | 4.81 | 8.51 | +3.69 | buy |
| Caligan Partners LP | 696,825 | 944,257 | +247,432 | 1.35 | 2.27 | +0.92 | buy |
| Point72 Asset Management, L.P. | 282,032 | 874,192 | +592,160 | 0.01 | 0.04 | +0.03 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 846,585 | 818,326 | -28,259 | 0.02 | 0.04 | +0.02 | sell |
| STATE STREET CORP | 428,472 | 749,463 | +320,991 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 602,015 | 711,891 | +109,876 | 0.01 | 0.02 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 597,454 | 657,756 | +60,302 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 514,947 | 526,002 | +11,055 | 1.82 | 2.29 | +0.47 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 398,482 | +398,482 | 0.00 | 3.29 | +3.29 | buy |
| Eversept Partners, LP | 272,706 | 278,564 | +5,858 | 0.29 | 0.41 | +0.12 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 186,670 | 221,177 | +34,507 | 0.07 | 0.15 | +0.08 | buy |
| Logos Global Management LP | 0 | 210,000 | +210,000 | 0.00 | 0.37 | +0.37 | buy |
| NORTHERN TRUST CORP | 208,486 | 200,956 | -7,530 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 201,587 | 199,426 | -2,161 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 100,150 | 182,387 | +82,237 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 126,374 | 170,032 | +43,658 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 129,779 | +129,779 | 0.00 | 0.00 | +0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 251,562 | 129,753 | -121,809 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 15,510 | 129,435 | +113,925 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 125,000 | +125,000 | 0.00 | 0.14 | +0.14 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 128,881 | 120,278 | -8,603 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 322,143 | 118,898 | -203,245 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 144,016 | 114,388 | -29,628 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 199,438 | 107,023 | -92,415 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 82,871 | 104,305 | +21,434 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 39,679 | 95,640 | +55,961 | 0.00 | 0.00 | +0.00 | buy |
| INVESTMENT COUNSEL CO OF NEVADA | 85,020 | 85,020 | 0 | 2.42 | 4.80 | +2.38 | hold |
| OPPENHEIMER & CO INC | 82,238 | 84,726 | +2,488 | 0.01 | 0.03 | +0.02 | buy |
| BARCLAYS PLC | 57,126 | 76,309 | +19,183 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 74,229 | 71,175 | -3,054 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 57,162 | 60,901 | +3,739 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 113,200 | 58,900 | -54,300 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 59,144 | 58,856 | -288 | 0.00 | 0.00 | +0.00 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 58,677 | +58,677 | 0.00 | 0.83 | +0.83 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 55,135 | +55,135 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 87,107 | 54,625 | -32,482 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 12,214 | 54,424 | +42,210 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 48,644 | 48,644 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Nuveen, LLC | 80,441 | 47,349 | -33,092 | 0.00 | 0.00 | +0.00 | sell |
| ALGERT GLOBAL LLC | 0 | 46,870 | +46,870 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 38,412 | 46,227 | +7,815 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 45,942 | +45,942 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 24,700 | 43,827 | +19,127 | 0.00 | 0.01 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 42,791 | +42,791 | 0.00 | 0.01 | +0.01 | buy |
| PDT Partners, LLC | 43,310 | 42,284 | -1,026 | 0.04 | 0.07 | +0.03 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 29,648 | 39,023 | +9,375 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 40,636 | 38,790 | -1,846 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 134,319 | 38,310 | -96,009 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 65,812 | 35,086 | -30,726 | 0.23 | 0.24 | +0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 33,260 | 31,990 | -1,270 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 33,700 | 30,414 | -3,286 | 0.02 | 0.02 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 29,887 | +29,887 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,470 | 29,049 | +10,579 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 28,900 | +28,900 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 0 | 28,800 | +28,800 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 28,069 | 28,631 | +562 | 0.00 | 0.00 | +0.00 | buy |
| Auour Investments LLC | 21,020 | 21,020 | 0 | 0.10 | 0.18 | +0.08 | hold |
| Creative Planning | 0 | 19,603 | +19,603 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 18,790 | 18,790 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 24,962 | 18,542 | -6,420 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 15,483 | 16,377 | +894 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 15,455 | +15,455 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,631 | 15,356 | +725 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 12,801 | 14,432 | +1,631 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 12,741 | 12,996 | +255 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 12,970 | +12,970 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 11,317 | 12,908 | +1,591 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 12,529 | 12,563 | +34 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 11,015 | 11,756 | +741 | 0.04 | 0.08 | +0.04 | buy |
| BANK OF NOVA SCOTIA | 0 | 11,100 | +11,100 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 10,607 | 10,607 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 11,402 | 9,801 | -1,601 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,342 | 8,697 | -645 | 0.01 | 0.02 | +0.01 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 8,357 | +8,357 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,423 | 7,423 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,440 | 6,440 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 1,707 | 3,817 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| Bellevue Group AG | 0 | 3,143 | +3,143 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2,997 | +2,997 | 0.00 | 0.02 | +0.02 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,060 | 2,594 | +534 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,192 | 2,367 | +175 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 30,060 | 2,139 | -27,921 | 0.03 | 0.00 | -0.02 | sell |
| Chung Wu Investment Group, LLC | 0 | 2,000 | +2,000 | 0.00 | 0.04 | +0.04 | buy |
| Ameritas Investment Partners, Inc. | 1,991 | 1,991 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,473 | 1,595 | +122 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,529 | 1,546 | +17 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,662 | 1,488 | -174 | 0.00 | 0.00 | +0.00 | sell |