| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Caligan Partners LP | 696,825 | 944,257 | +247,432 | 1.28 | 2.04 | +0.77 | buy |
| 5AM Venture Management, LLC | 939,298 | 1,029,298 | +90,000 | 4.81 | 8.51 | +3.69 | buy |
| ALPS ADVISORS INC | 24,700 | 43,827 | +19,127 | 0.00 | 0.01 | 0.00 | buy |
| Sio Capital Management, LLC | 514,947 | 526,002 | +11,055 | 1.82 | 2.18 | +0.35 | buy |
| Eversept Partners, LP | 272,706 | 278,564 | +5,858 | 0.26 | 0.37 | +0.11 | buy |
| OPPENHEIMER & CO INC | 82,238 | 84,726 | +2,488 | 0.01 | 0.03 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 11,015 | 11,756 | +741 | 0.04 | 0.08 | +0.04 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,147 | 1,048 | -99 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 9,342 | 8,697 | -645 | 0.01 | 0.02 | +0.01 | sell |
| PDT Partners, LLC | 43,310 | 42,284 | -1,026 | 0.04 | 0.07 | +0.03 | sell |
| HighVista Strategies LLC | 65,812 | 35,086 | -30,726 | 0.23 | 0.24 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 251,562 | 129,753 | -121,809 | 0.01 | 0.01 | -0.00 | sell |
| Canaan Partners XI LLC | 3,608,109 | 3,374,329 | -233,780 | 49.07 | 64.85 | +15.78 | sell |
| Alta Partners Management Company, L.P. | 4,080,296 | 3,823,425 | -256,871 | 95.15 | 97.03 | +1.88 | sell |
| Kynam Capital Management, LP | 2,329,998 | 1,564,492 | -765,506 | 2.43 | 2.68 | +0.25 | sell |
| BVF INC/IL | 3,649,794 | 2,127,665 | -1,522,129 | 2.07 | 1.88 | -0.19 | sell |