| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 314,600 | +314,600 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 88,900 | 167,200 | +78,300 | 0.00 | 0.00 | +0.00 | buy |
| Marex Group plc | 0 | 45,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 12,730 | 33,307 | +20,577 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,867 | +15,867 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.01 | 0.01 | -0.00 | hold |
| PFM Health Sciences, LP | 2,341,107 | 2,341,107 | 0 | 0.26 | 0.20 | -0.06 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.95 | 0.84 | -0.11 | hold |
| Samsara BioCapital, LLC | 3,640,015 | 3,640,015 | 0 | 1.06 | 0.97 | -0.09 | hold |
| Logos Global Management LP | 493,827 | 493,827 | 0 | 0.10 | 0.09 | -0.01 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.41 | 0.96 | +0.55 | hold |
| BANK OF AMERICA CORP /DE/ | 1,844,185 | 1,844,185 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COMERICA BANK | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 145,200 | 124,623 | -20,577 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 51,867 | 0 | -51,867 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,281,682 | 2,197,234 | -84,448 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 1,924,000 | 1,724,000 | -200,000 | 0.10 | 0.08 | -0.02 | sell |
| Novo Holdings A/S | 5,747,067 | 5,088,258 | -658,809 | 0.67 | 0.61 | -0.06 | sell |
| Stonepine Capital Management, LLC | 1,666,037 | 156,167 | -1,509,870 | 1.35 | 0.21 | -1.14 | sell |