| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| XTX Topco Ltd | 28,040 | 50,486 | +22,446 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 75,000 | 95,000 | +20,000 | 0.05 | 0.08 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 118,800 | 126,400 | +7,600 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 3,354,449 | 3,354,449 | 0 | 0.19 | 0.28 | +0.09 | hold |
| PFM Health Sciences, LP | 2,341,107 | 2,341,107 | 0 | 0.16 | 0.20 | +0.03 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.64 | 0.89 | +0.25 | hold |
| Soleus Capital Management, L.P. | 192,670 | 192,670 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.54 | 0.76 | +0.23 | hold |
| SBI Securities Co., Ltd. | 130 | 130 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Marex Group plc | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 1,651,515 | 1,651,515 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 12,384 | 0 | -12,384 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 32,667 | 20,029 | -12,638 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 12,689 | 0 | -12,689 | 0.00 | 0.00 | -0.00 | sell |
| PKS Advisory Services, LLC | 16,000 | 0 | -16,000 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 20,000 | 0 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 60,650 | 30,858 | -29,792 | 0.00 | 0.00 | -0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 442,196 | 400,234 | -41,962 | 0.04 | 0.04 | -0.00 | sell |
| Dauntless Investment Group, LLC | 747,646 | 681,446 | -66,200 | 2.91 | 2.74 | -0.16 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 174,000 | 75,000 | -99,000 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 270,504 | 0 | -270,504 | 0.00 | 0.00 | -0.00 | sell |