| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 0 | 192,670 | +192,670 | 0.00 | 0.02 | +0.02 | buy |
| CITADEL ADVISORS LLC | 0 | 86,894 | +86,894 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 167,200 | 180,800 | +13,600 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 15,867 | 26,555 | +10,688 | 0.00 | 0.00 | -0.00 | buy |
| Redwood Wealth Management Group, LLC | 0 | 4,166 | +4,166 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 124,623 | 124,623 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.01 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 2,341,107 | 2,341,107 | 0 | 0.20 | 0.15 | -0.05 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.84 | 0.67 | -0.17 | hold |
| Samsara BioCapital, LLC | 3,640,015 | 3,640,015 | 0 | 0.97 | 0.89 | -0.08 | hold |
| Logos Global Management LP | 493,827 | 493,827 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.96 | 0.78 | -0.18 | hold |
| Marex Group plc | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 314,600 | 314,600 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Stonepine Capital Management, LLC | 156,167 | 0 | -156,167 | 0.21 | 0.00 | -0.21 | sell |
| ARMISTICE CAPITAL, LLC | 1,724,000 | 1,545,000 | -179,000 | 0.08 | 0.05 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 1,844,185 | 1,651,515 | -192,670 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 2,197,234 | 1,972,343 | -224,891 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 5,088,258 | 4,429,449 | -658,809 | 0.61 | 0.28 | -0.33 | sell |