| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NewEdge Advisors, LLC | 0 | 24,217 | +24,217 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 95,000 | 117,691 | +22,691 | 0.08 | 0.11 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 13,096 | +13,096 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 126,400 | 139,300 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 10,385 | +10,385 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 314 | +314 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 130 | 132 | +2 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Novo Holdings A/S | 3,354,449 | 3,354,449 | 0 | 0.28 | 0.33 | +0.05 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.89 | 0.88 | -0.01 | hold |
| Soleus Capital Management, L.P. | 192,670 | 192,670 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.76 | 0.74 | -0.02 | hold |
| Marex Group plc | 45,000 | 45,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 30,858 | 23,366 | -7,492 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 20,029 | 0 | -20,029 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 50,486 | 29,189 | -21,297 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,651,515 | 1,615,074 | -36,441 | 0.00 | 0.00 | +0.00 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 400,234 | 347,408 | -52,826 | 0.04 | 0.04 | -0.00 | sell |
| Dauntless Investment Group, LLC | 681,446 | 324,389 | -357,057 | 2.74 | 2.12 | -0.62 | sell |
| PFM Health Sciences, LP | 2,341,107 | 1,972,073 | -369,034 | 0.20 | 0.24 | +0.04 | sell |