| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 1,972,343 | 2,202,085 | +229,742 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 124,623 | 199,623 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 60,650 | +60,650 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 26,646 | +26,646 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 17,954 | +17,954 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PFM Health Sciences, LP | 2,341,107 | 2,341,107 | 0 | 0.15 | 0.14 | -0.01 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.67 | 0.54 | -0.13 | hold |
| Samsara BioCapital, LLC | 3,640,015 | 3,640,015 | 0 | 0.89 | 0.73 | -0.16 | hold |
| Logos Global Management LP | 493,827 | 493,827 | 0 | 0.07 | 0.06 | -0.01 | hold |
| Soleus Capital Management, L.P. | 192,670 | 192,670 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.78 | 0.54 | -0.24 | hold |
| Marex Group plc | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 1,651,515 | 1,651,515 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Redwood Wealth Management Group, LLC | 4,166 | 0 | -4,166 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 26,555 | 0 | -26,555 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 180,800 | 97,000 | -83,800 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 86,894 | 0 | -86,894 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 314,600 | 0 | -314,600 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 4,429,449 | 3,354,449 | -1,075,000 | 0.28 | 0.17 | -0.10 | sell |
| ARMISTICE CAPITAL, LLC | 1,545,000 | 0 | -1,545,000 | 0.05 | 0.00 | -0.05 | sell |