| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Ikarian Capital, LLC | 0 | 1,525,893 | +1,525,893 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 1,392,396 | +1,392,396 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 591,180 | +591,180 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 139,300 | 547,315 | +408,015 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 250,000 | +250,000 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 29,189 | 179,207 | +150,018 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 83,382 | +83,382 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 39,063 | +39,063 | 0.00 | 0.00 | +0.00 | buy |
| Hilton Capital Management, LLC | 0 | 25,510 | +25,510 | 0.00 | 0.00 | +0.00 | buy |
| PKS Advisory Services, LLC | 0 | 19,500 | +19,500 | 0.00 | 0.00 | +0.00 | buy |
| NewEdge Advisors, LLC | 24,217 | 25,692 | +1,475 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 314 | 1,292 | +978 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 75,000 | 75,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SBI Securities Co., Ltd. | 132 | 122 | -10 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA SECURITIES, LLC | 10,385 | 0 | -10,385 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 13,096 | 0 | -13,096 | 0.00 | 0.00 | -0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 23,366 | 0 | -23,366 | 0.00 | 0.00 | -0.00 | sell |
| Marex Group plc | 45,000 | 0 | -45,000 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 117,691 | 0 | -117,691 | 0.11 | 0.00 | -0.11 | sell |
| Soleus Capital Management, L.P. | 192,670 | 0 | -192,670 | 0.02 | 0.00 | -0.02 | sell |
| Dauntless Investment Group, LLC | 324,389 | 0 | -324,389 | 2.12 | 0.00 | -2.12 | sell |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 347,408 | 0 | -347,408 | 0.04 | 0.00 | -0.04 | sell |
| Novo Holdings A/S | 3,354,449 | 2,512,453 | -841,996 | 0.33 | 0.06 | -0.27 | sell |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 0 | -864,197 | 0.74 | 0.00 | -0.74 | sell |
| MARSHALL WACE, LLP | 2,105,262 | 1,052,631 | -1,052,631 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,615,074 | 0 | -1,615,074 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 1,972,073 | 0 | -1,972,073 | 0.24 | 0.00 | -0.24 | sell |
| Vivo Capital, LLC | 6,173,439 | 0 | -6,173,439 | 0.88 | 0.00 | -0.88 | sell |