| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 2,281,682 | +2,281,682 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 1,353,453 | 2,341,107 | +987,654 | 0.09 | 0.26 | +0.17 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 24,386 | 88,900 | +64,514 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 51,867 | +51,867 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 132,200 | 145,200 | +13,000 | 0.00 | 0.01 | +0.00 | buy |
| COMERICA BANK | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 12,730 | 12,730 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Novo Holdings A/S | 5,747,067 | 5,747,067 | 0 | 0.60 | 0.67 | +0.07 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.95 | 0.95 | -0.00 | hold |
| Samsara BioCapital, LLC | 3,640,015 | 3,640,015 | 0 | 1.57 | 1.06 | -0.51 | hold |
| Logos Global Management LP | 493,827 | 493,827 | 0 | 0.10 | 0.10 | +0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.49 | 0.41 | -0.07 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,100 | 10,000 | -100 | 0.00 | 0.00 | +0.00 | sell |
| Ancora Advisors LLC | 908 | 0 | -908 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,854,185 | 1,844,185 | -10,000 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 21,238 | 0 | -21,238 | 0.01 | 0.00 | -0.01 | sell |
| ARMISTICE CAPITAL, LLC | 2,148,000 | 1,924,000 | -224,000 | 0.09 | 0.10 | +0.01 | sell |
| Stonepine Capital Management, LLC | 1,975,308 | 1,666,037 | -309,271 | 0.93 | 1.35 | +0.43 | sell |
| Alyeska Investment Group, L.P. | 987,654 | 0 | -987,654 | 0.01 | 0.00 | -0.01 | sell |
| Avoro Capital Advisors LLC | 2,055,883 | 0 | -2,055,883 | 0.04 | 0.00 | -0.04 | sell |