| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 442,196 | +442,196 | 0.00 | 0.04 | +0.04 | buy |
| CITADEL ADVISORS LLC | 0 | 270,504 | +270,504 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 75,000 | +75,000 | 0.00 | 0.05 | +0.05 | buy |
| Vontobel Holding Ltd. | 0 | 32,667 | +32,667 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 28,040 | +28,040 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 97,000 | 118,800 | +21,800 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 12,384 | +12,384 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 33,307 | 33,307 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MARSHALL WACE, LLP | 2,105,262 | 2,105,262 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Novo Holdings A/S | 3,354,449 | 3,354,449 | 0 | 0.17 | 0.19 | +0.01 | hold |
| PFM Health Sciences, LP | 2,341,107 | 2,341,107 | 0 | 0.14 | 0.16 | +0.02 | hold |
| Vivo Capital, LLC | 6,173,439 | 6,173,439 | 0 | 0.54 | 0.64 | +0.10 | hold |
| Soleus Capital Management, L.P. | 192,670 | 192,670 | 0 | 0.02 | 0.01 | -0.00 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 864,197 | 864,197 | 0 | 0.54 | 0.54 | -0.00 | hold |
| Marex Group plc | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 1,651,515 | 1,651,515 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ACADIAN ASSET MANAGEMENT LLC | 60,650 | 60,650 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HRT FINANCIAL LP | 26,646 | 12,689 | -13,957 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 17,954 | 0 | -17,954 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 199,623 | 174,000 | -25,623 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 493,827 | 0 | -493,827 | 0.06 | 0.00 | -0.06 | sell |
| MORGAN STANLEY | 2,202,085 | 0 | -2,202,085 | 0.00 | 0.00 | -0.00 | sell |
| Samsara BioCapital, LLC | 3,640,015 | 0 | -3,640,015 | 0.73 | 0.00 | -0.73 | sell |