| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| HHLR ADVISORS, LTD. | 0 | 3,929,117 | +3,929,117 | 0.00 | 1.52 | +1.52 | buy |
| ORBIMED ADVISORS LLC | 0 | 3,027,328 | +3,027,328 | 0.00 | 0.99 | +0.99 | buy |
| FMR LLC | 0 | 1,950,034 | +1,950,034 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 0 | 1,943,836 | +1,943,836 | 0.00 | 4.22 | +4.22 | buy |
| Sofinnova Investments, Inc. | 0 | 1,696,752 | +1,696,752 | 0.00 | 1.79 | +1.79 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 0 | 1,563,709 | +1,563,709 | 0.00 | 1.18 | +1.18 | buy |
| General Catalyst Group Management, LLC | 0 | 1,494,786 | +1,494,786 | 0.00 | 2.05 | +2.05 | buy |
| Novo Holdings A/S | 0 | 1,077,140 | +1,077,140 | 0.00 | 1.33 | +1.33 | buy |
| HSG Holding Ltd | 0 | 663,308 | +663,308 | 0.00 | 0.97 | +0.97 | buy |
| VANGUARD GROUP INC | 0 | 648,735 | +648,735 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 515,000 | +515,000 | 0.00 | 0.41 | +0.41 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 415,000 | +415,000 | 0.00 | 0.13 | +0.13 | buy |
| CITADEL ADVISORS LLC | 0 | 286,512 | +286,512 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 225,049 | +225,049 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 211,689 | +211,689 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 151,768 | +151,768 | 0.00 | 0.02 | +0.02 | buy |
| STATE STREET CORP | 0 | 122,264 | +122,264 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 0 | 78,409 | +78,409 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 77,760 | +77,760 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| JANE STREET GROUP, LLC | 0 | 36,959 | +36,959 | 0.00 | 0.00 | +0.00 | buy |
| MYDA Advisors LLC | 0 | 30,000 | +30,000 | 0.00 | 0.19 | +0.19 | buy |
| Point72 Asset Management, L.P. | 0 | 28,900 | +28,900 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 26,181 | +26,181 | 0.00 | 0.01 | +0.01 | buy |
| Blackstone Inc. | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 25,000 | +25,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 22,707 | +22,707 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 14,208 | +14,208 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 12,556 | +12,556 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 9,895 | +9,895 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 9,765 | +9,765 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 5,514 | +5,514 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 0 | 4,845 | +4,845 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,659 | +4,659 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 4,360 | +4,360 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,231 | +3,231 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,741 | +1,741 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 989 | +989 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 981 | +981 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 896 | +896 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 604 | +604 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 0 | 567 | +567 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 540 | +540 | 0.00 | 0.00 | +0.00 | buy |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |