| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| INFINITUM ASSET MANAGEMENT, LLC | 1,643,923 | 2,066,238 | +422,315 | 23.15 | 12.22 | -10.93 | buy |
| Novo Holdings A/S | 1,520,627 | 1,872,142 | +351,515 | 2.45 | 2.63 | +0.18 | buy |
| UBS Group AG | 72,693 | 202,185 | +129,492 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 52,545 | 158,058 | +105,513 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,246,000 | 2,337,496 | +91,496 | 2.22 | 1.75 | -0.47 | buy |
| VANGUARD GROUP INC | 1,417,291 | 1,503,358 | +86,067 | 0.00 | 0.00 | -0.00 | buy |
| Hidden Lake Asset Management LP | 184,605 | 254,371 | +69,766 | 3.36 | 4.64 | +1.28 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 41,381 | +41,381 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 35,851 | +35,851 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 22,268 | +22,268 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 41,921 | 61,348 | +19,427 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 17,836 | 36,791 | +18,955 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 18,426 | +18,426 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 596,182 | 614,523 | +18,341 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 18,000 | +18,000 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 15,293 | +15,293 | 0.00 | 0.00 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 14,379 | +14,379 | 0.00 | 0.04 | +0.04 | buy |
| SG Americas Securities, LLC | 11,807 | 22,680 | +10,873 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 10,090 | +10,090 | 0.00 | 0.15 | +0.15 | buy |
| Virtus Investment Advisers, LLC | 0 | 6,348 | +6,348 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 2,135,092 | 2,139,788 | +4,696 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 14,798 | 18,069 | +3,271 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 10,965 | 12,471 | +1,506 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 15,685 | 16,329 | +644 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 145,797 | 146,373 | +576 | 0.03 | 0.02 | -0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 457 | +457 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 36,690 | 37,143 | +453 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,114 | 17,546 | +432 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,018 | 10,404 | +386 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 13 | 383 | +370 | 0.00 | 0.01 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 14,493 | 14,819 | +326 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 68,003 | 68,225 | +222 | 0.00 | 0.00 | -0.00 | buy |
| US BANCORP \DE\ | 105 | 322 | +217 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 708 | 863 | +155 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 70 | 145 | +75 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 34,121 | 34,169 | +48 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 45 | 70 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 107 | 127 | +20 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,123 | 1,128 | +5 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 4 | +4 | 0.00 | 0.00 | 0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.67 | 1.34 | -0.33 | hold |
| Ameritas Investment Partners, Inc. | 2,854 | 2,854 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,649 | 13,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 28,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.69 | 0.82 | +0.13 | hold |
| Daiwa Securities Group Inc. | 111 | 111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 26,400 | 26,400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 3.31 | 2.37 | -0.95 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 3.49 | 3.11 | -0.37 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 4,484,672 | 4,484,672 | 0 | 4.14 | 2.34 | -1.80 | hold |
| Octagon Capital Advisors LP | 2,059,387 | 2,059,387 | 0 | 9.33 | 5.20 | -4.13 | hold |
| SBI Securities Co., Ltd. | 25 | 25 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,255 | 6,255 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | 7,783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 963 | 963 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 21 | 0 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 13,627 | 13,593 | -34 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 96 | 27 | -69 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 119 | 0 | -119 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 373 | 209 | -164 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 14,007 | 13,803 | -204 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 15,339 | 15,130 | -209 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 555 | 281 | -274 | 0.01 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 17,460 | 17,110 | -350 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,145 | 6,759 | -386 | 0.02 | 0.01 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 1,599 | 993 | -606 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 24,136 | 23,183 | -953 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 996 | 0 | -996 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 3,300 | 1,962 | -1,338 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 27,252 | 25,167 | -2,085 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,747 | 0 | -2,747 | 0.03 | 0.00 | -0.03 | sell |
| NORTHERN TRUST CORP | 241,009 | 237,701 | -3,308 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 8,165 | 0 | -8,165 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 8,373 | 0 | -8,373 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 8,868 | 0 | -8,868 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 9,532 | 0 | -9,532 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 206,379 | 196,494 | -9,885 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 27,299 | 17,409 | -9,890 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 53,499 | 40,583 | -12,916 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 45,544 | 29,285 | -16,259 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,101,037 | 2,078,659 | -22,378 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 148,584 | 121,938 | -26,646 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 814,091 | 767,740 | -46,351 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 207,269 | 76,877 | -130,392 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 585,462 | 0 | -585,462 | 0.86 | 0.00 | -0.86 | sell |