| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,106,035 | 4,401,083 | +295,048 | 2.06 | 2.75 | +0.69 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 4,123,923 | 4,148,923 | +25,000 | 12.28 | 11.98 | -0.30 | buy |
| HHLR ADVISORS, LTD. | 3,929,117 | 3,929,117 | 0 | 2.55 | 5.42 | +2.87 | hold |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.25 | 1.52 | +0.28 | hold |
| FMR LLC | 3,703,572 | 3,016,132 | -687,440 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 2,372,838 | 2,530,301 | +157,463 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,971,054 | 1,971,054 | 0 | 4.96 | 5.03 | +0.07 | hold |
| Novo Holdings A/S | 1,942,142 | 1,942,142 | 0 | 3.03 | 3.63 | +0.60 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 1.47 | 1.96 | +0.49 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 13.56 | 18.79 | +5.22 | hold |
| STATE STREET CORP | 1,091,980 | 1,421,415 | +329,435 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 0 | 885,916 | +885,916 | 0.00 | 1.70 | +1.70 | buy |
| GOLDMAN SACHS GROUP INC | 742,526 | 853,427 | +110,901 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 753,519 | 803,652 | +50,133 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 216,660 | 748,195 | +531,535 | 0.01 | 0.03 | +0.02 | buy |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.88 | 0.86 | -0.02 | hold |
| Fund 1 Investments, LLC | 565,851 | 499,990 | -65,861 | 1.65 | 1.50 | -0.15 | sell |
| UBS Group AG | 450,920 | 486,263 | +35,343 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 43,030 | 426,281 | +383,251 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 281,952 | 425,923 | +143,971 | 0.00 | 0.01 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 233,324 | 368,795 | +135,471 | 0.00 | 0.01 | +0.00 | buy |
| Logos Global Management LP | 0 | 350,000 | +350,000 | 0.00 | 0.42 | +0.42 | buy |
| NORTHERN TRUST CORP | 245,599 | 268,812 | +23,213 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 250,588 | 258,772 | +8,184 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 242,050 | +242,050 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 118,485 | 180,028 | +61,543 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 150,000 | 175,000 | +25,000 | 0.22 | 0.24 | +0.02 | buy |
| CITADEL ADVISORS LLC | 458,502 | 166,157 | -292,345 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 147,386 | 147,639 | +253 | 0.01 | 0.01 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 141,814 | +141,814 | 0.00 | 0.20 | +0.20 | buy |
| MORGAN STANLEY | 97,590 | 128,546 | +30,956 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 14,743 | 126,525 | +111,782 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 122,276 | +122,276 | 0.00 | 0.40 | +0.40 | buy |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.13 | 0.11 | -0.02 | hold |
| E Fund Management Co., Ltd. | 0 | 93,953 | +93,953 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 56,521 | 80,208 | +23,687 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 82,278 | 78,213 | -4,065 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 73,111 | 75,448 | +2,337 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 70,317 | +70,317 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 69,394 | 65,879 | -3,515 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 129,173 | 65,408 | -63,765 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 26,253 | 63,002 | +36,749 | 0.01 | 0.03 | +0.01 | buy |
| Nuveen, LLC | 53,618 | 56,839 | +3,221 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 56,659 | 56,088 | -571 | 0.21 | 0.23 | +0.02 | sell |
| Squarepoint Ops LLC | 186,492 | 55,432 | -131,060 | 0.01 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 51,437 | 48,716 | -2,721 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 77,479 | 48,682 | -28,797 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 53,424 | 47,053 | -6,371 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 40,000 | 40,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 28,878 | 37,253 | +8,375 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 33,896 | 35,986 | +2,090 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 98,984 | 35,165 | -63,819 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 31,456 | 35,148 | +3,692 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 30,996 | +30,996 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,828 | 30,898 | -211,930 | 0.01 | 0.00 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 38,255 | 30,013 | -8,242 | 0.62 | 0.60 | -0.02 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 28,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 21,531 | 27,979 | +6,448 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 27,239 | +27,239 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,892 | 23,941 | +7,049 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 16,115 | 22,593 | +6,478 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,101 | +22,101 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 24,221 | 21,900 | -2,321 | 0.01 | 0.01 | +0.00 | sell |
| Man Group plc | 0 | 20,727 | +20,727 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 19,515 | +19,515 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 21,681 | 19,367 | -2,314 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 60,129 | 19,025 | -41,104 | 0.01 | 0.00 | -0.01 | sell |
| Optimize Financial Inc | 0 | 18,916 | +18,916 | 0.00 | 0.21 | +0.21 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,378 | 17,726 | +2,348 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 103,255 | 17,658 | -85,597 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 16,657 | 17,324 | +667 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 40,300 | 17,308 | -22,992 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 10,984 | 16,813 | +5,829 | 0.01 | 0.01 | +0.01 | buy |
| IvyRock Asset Management (HK) Ltd | 0 | 16,000 | +16,000 | 0.00 | 0.21 | +0.21 | buy |
| Caption Management, LLC | 0 | 15,967 | +15,967 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 11,475 | 15,923 | +4,448 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 15,331 | +15,331 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 15,275 | 14,676 | -599 | 0.00 | 0.00 | +0.00 | sell |
| Brooklyn Investment Group | 0 | 14,125 | +14,125 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 12,763 | 13,307 | +544 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 4,743 | 13,106 | +8,363 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 12,252 | +12,252 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 32,280 | 12,124 | -20,156 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 11,007 | 11,819 | +812 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,007 | 11,357 | +350 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,894 | 11,165 | +271 | 0.06 | 0.07 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 5,473 | 9,576 | +4,103 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 9,068 | +9,068 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 8,935 | +8,935 | 0.00 | 0.03 | +0.03 | buy |
| Persistent Asset Partners Ltd | 7,963 | 8,108 | +145 | 0.08 | 0.07 | -0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,881 | 7,881 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | 7,783 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CITIGROUP INC | 8,093 | 7,435 | -658 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 6,727 | 7,326 | +599 | 0.01 | 0.01 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 4,300 | 4,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 2,370 | 2,500 | +130 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,352 | 2,352 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 2,006 | 2,153 | +147 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,068 | 2,068 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 1,111 | 1,222 | +111 | 0.00 | 0.00 | +0.00 | buy |