| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| HHLR ADVISORS, LTD. | 3,929,117 | 4,484,672 | +555,555 | 1.52 | 2.05 | +0.53 | buy |
| Novo Holdings A/S | 1,077,140 | 1,500,000 | +422,860 | 1.33 | 1.50 | +0.17 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,563,709 | 1,712,703 | +148,994 | 1.18 | 1.30 | +0.12 | buy |
| Hidden Lake Asset Management LP | 0 | 37,121 | +37,121 | 0.00 | 0.59 | +0.59 | buy |
| STATE STREET CORP | 122,264 | 153,623 | +31,359 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 26,139 | +26,139 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,659 | 16,568 | +11,909 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 225,049 | 234,944 | +9,895 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 22,707 | 29,847 | +7,140 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 9,765 | 12,707 | +2,942 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 2,883 | +2,883 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 648,735 | 651,074 | +2,339 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 9,895 | 11,985 | +2,090 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,760 | 79,727 | +1,967 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 604 | 1,492 | +888 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,514 | 6,081 | +567 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,741 | 2,163 | +422 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 390 | +390 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,231 | 3,603 | +372 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,950,034 | 1,950,181 | +147 | 0.00 | 0.00 | -0.00 | buy |
| Arax Advisory Partners | 0 | 119 | +119 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 58 | +58 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 896 | 954 | +58 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 27 | +27 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 0.99 | 1.12 | +0.12 | hold |
| Ameritas Investment Partners, Inc. | 981 | 981 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 415,000 | 415,000 | 0 | 0.13 | 0.19 | +0.06 | hold |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.97 | 0.55 | -0.42 | hold |
| Cormorant Asset Management, LP | 515,000 | 515,000 | 0 | 0.41 | 0.56 | +0.15 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 1.79 | 1.98 | +0.20 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 2.05 | 2.39 | +0.34 | hold |
| Walleye Capital LLC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 100,000 | 100,000 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Ghisallo Capital Management LLC | 50,000 | 50,000 | 0 | 0.10 | 0.08 | -0.02 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 1,700 | 1,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 540 | 540 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 78,409 | 78,190 | -219 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 989 | 711 | -278 | 0.00 | 0.00 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 567 | 0 | -567 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 4,360 | 0 | -4,360 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 4,845 | 0 | -4,845 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 14,208 | 3,390 | -10,818 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 12,556 | 0 | -12,556 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 21,890 | 0 | -21,890 | 0.03 | 0.00 | -0.03 | sell |
| Blackstone Inc. | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,181 | 0 | -26,181 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 28,900 | 0 | -28,900 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 30,000 | 0 | -30,000 | 0.19 | 0.00 | -0.19 | sell |
| JANE STREET GROUP, LLC | 36,959 | 0 | -36,959 | 0.00 | 0.00 | -0.00 | sell |
| Octagon Capital Advisors LP | 1,943,836 | 1,803,304 | -140,532 | 4.22 | 5.52 | +1.30 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 151,768 | 0 | -151,768 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 211,689 | 12,103 | -199,586 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 286,512 | 0 | -286,512 | 0.00 | 0.00 | -0.00 | sell |