| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 4,401,083 | 4,515,531 | +114,448 | 2.75 | 3.30 | +0.54 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 4,148,923 | 4,438,384 | +289,461 | 11.98 | 15.68 | +3.70 | buy |
| HHLR ADVISORS, LTD. | 3,929,117 | 3,929,117 | 0 | 5.42 | 16.40 | +10.99 | hold |
| BlackRock, Inc. | 2,530,301 | 3,250,396 | +720,095 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.52 | 1.99 | +0.47 | hold |
| FMR LLC | 3,016,132 | 2,778,959 | -237,173 | 0.00 | 0.00 | +0.00 | sell |
| Octagon Capital Advisors LP | 1,971,054 | 1,971,054 | 0 | 5.03 | 6.28 | +1.25 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 1.96 | 3.15 | +1.19 | hold |
| STATE STREET CORP | 1,421,415 | 1,692,986 | +271,571 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 885,916 | 1,682,097 | +796,181 | 1.70 | 5.34 | +3.64 | buy |
| Novo Holdings A/S | 1,942,142 | 1,500,000 | -442,142 | 3.63 | 3.03 | -0.60 | sell |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 18.79 | 27.55 | +8.76 | hold |
| Logos Global Management LP | 350,000 | 1,000,000 | +650,000 | 0.42 | 1.50 | +1.08 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 803,652 | 972,626 | +168,974 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 368,795 | 872,011 | +503,216 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 853,427 | 853,723 | +296 | 0.00 | 0.00 | +0.00 | buy |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.86 | 1.92 | +1.06 | hold |
| Point72 Asset Management, L.P. | 748,195 | 566,796 | -181,399 | 0.03 | 0.03 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 425,923 | 438,664 | +12,741 | 0.01 | 0.01 | +0.00 | buy |
| UBS Group AG | 486,263 | 438,594 | -47,669 | 0.00 | 0.00 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 426,281 | 395,447 | -30,834 | 0.02 | 0.03 | +0.01 | sell |
| AMERIPRISE FINANCIAL INC | 180,028 | 381,589 | +201,561 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 268,812 | 332,753 | +63,941 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 0 | 301,341 | +301,341 | 0.00 | 1.63 | +1.63 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 294,224 | +294,224 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 258,772 | 294,224 | +35,452 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 218,694 | +218,694 | 0.00 | 5.29 | +5.29 | buy |
| DIMENSIONAL FUND ADVISORS LP | 126,525 | 211,509 | +84,984 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 128,546 | 189,910 | +61,364 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 80,208 | 174,866 | +94,658 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 166,157 | 156,742 | -9,415 | 0.00 | 0.00 | +0.00 | sell |
| NOMURA HOLDINGS INC | 242,050 | 154,617 | -87,433 | 0.05 | 0.02 | -0.02 | sell |
| Woodline Partners LP | 147,639 | 147,639 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 175,000 | 125,000 | -50,000 | 0.24 | 0.21 | -0.02 | sell |
| HRT FINANCIAL LP | 47,053 | 121,224 | +74,171 | 0.00 | 0.01 | +0.00 | buy |
| E Fund Management Co., Ltd. | 93,953 | 109,328 | +15,375 | 0.06 | 0.09 | +0.02 | buy |
| Nuveen, LLC | 56,839 | 107,851 | +51,012 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 75,448 | 103,931 | +28,483 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 78,213 | 100,855 | +22,642 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 100,000 | 100,000 | 0 | 0.11 | 0.13 | +0.01 | hold |
| SECTORAL ASSET MANAGEMENT INC | 30,013 | 79,043 | +49,030 | 0.60 | 1.92 | +1.32 | buy |
| Trexquant Investment LP | 0 | 71,860 | +71,860 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 65,408 | 70,970 | +5,562 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 65,879 | 65,692 | -187 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 63,002 | 62,332 | -670 | 0.03 | 0.03 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 48,682 | 57,804 | +9,122 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 57,034 | +57,034 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 57,034 | +57,034 | 0.00 | 0.06 | +0.06 | buy |
| Soleus Capital Management, L.P. | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| Quadrature Capital Ltd | 13,307 | 49,125 | +35,818 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 40,000 | 48,800 | +8,800 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 35,986 | 47,074 | +11,088 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 35,148 | 46,254 | +11,106 | 0.00 | 0.00 | +0.00 | buy |
| MOODY ALDRICH PARTNERS LLC | 56,088 | 44,044 | -12,044 | 0.23 | 0.27 | +0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 43,560 | +15,360 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,435 | 41,265 | +33,830 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 27,979 | 39,180 | +11,201 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 12,124 | 36,670 | +24,546 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 30,996 | 36,651 | +5,655 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 23,941 | 32,966 | +9,025 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 22,593 | 31,551 | +8,958 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 21,900 | 29,644 | +7,744 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 30,898 | 28,582 | -2,316 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,106 | 28,283 | +15,177 | 0.00 | 0.00 | +0.00 | buy |
| Ellsworth Advisors, LLC | 0 | 27,001 | +27,001 | 0.00 | 0.15 | +0.15 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 19,367 | 26,798 | +7,431 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 48,716 | 24,805 | -23,911 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 37,253 | 24,380 | -12,873 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 22,101 | 23,287 | +1,186 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 17,324 | 22,360 | +5,036 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 22,259 | +22,259 | 0.00 | 0.01 | +0.01 | buy |
| AQR CAPITAL MANAGEMENT LLC | 15,923 | 21,517 | +5,594 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 27,239 | 20,430 | -6,809 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,726 | 20,294 | +2,568 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 19,515 | 19,534 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 18,916 | 18,851 | -65 | 0.21 | 0.24 | +0.02 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 15,331 | 17,579 | +2,248 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 55,432 | 17,544 | -37,888 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 15,967 | 15,967 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Persistent Asset Partners Ltd | 8,108 | 15,734 | +7,626 | 0.07 | 0.17 | +0.10 | buy |
| Legal & General Group Plc | 14,676 | 15,481 | +805 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | 14,783 | +7,000 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 16,813 | 12,643 | -4,170 | 0.01 | 0.01 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,898 | +11,898 | 0.00 | 0.07 | +0.07 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 11,843 | +11,843 | 0.00 | 0.01 | +0.01 | buy |
| Jain Global LLC | 0 | 11,487 | +11,487 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 11,357 | 11,357 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DeepCurrents Investment Group LLC | 0 | 11,227 | +11,227 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,881 | 11,184 | +3,303 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 9,576 | 11,170 | +1,594 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 11,165 | 10,714 | -451 | 0.07 | 0.09 | +0.02 | sell |
| Aquatic Capital Management LLC | 460 | 10,598 | +10,138 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,068 | 10,363 | +1,295 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 10,013 | +10,013 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 9,883 | +9,883 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 12,252 | 9,670 | -2,582 | 0.00 | 0.01 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 11,819 | 9,567 | -2,252 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,375 | +9,375 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,068 | 9,134 | +7,066 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 8,823 | +8,823 | 0.00 | 0.00 | +0.00 | buy |