| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 651,074 | 1,345,550 | +694,476 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 234,944 | 597,165 | +362,221 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 153,623 | 476,809 | +323,186 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 12,103 | 216,630 | +204,527 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,803,304 | 1,976,387 | +173,083 | 5.52 | 7.44 | +1.92 | buy |
| FMR LLC | 1,950,181 | 2,119,695 | +169,514 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 167,734 | +167,734 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 78,190 | 230,511 | +152,321 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,712,703 | 1,845,162 | +132,459 | 1.30 | 1.56 | +0.26 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 79,727 | 202,368 | +122,641 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 85,250 | +85,250 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 72,968 | +72,968 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 515,000 | 585,462 | +70,462 | 0.56 | 0.73 | +0.17 | buy |
| Saturn V Capital Management LP | 0 | 47,266 | +47,266 | 0.00 | 0.40 | +0.40 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 43,265 | +43,265 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 29,847 | 68,321 | +38,474 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,390 | 41,522 | +38,132 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 28,200 | +28,200 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 100,000 | 120,944 | +20,944 | 0.02 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 12,707 | 33,621 | +20,914 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,163 | 20,400 | +18,237 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 15,331 | +15,331 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 12,445 | +12,445 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 11,927 | +11,927 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 11,354 | +11,354 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,881 | 15,787 | +10,906 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,081 | 16,350 | +10,269 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,234 | +10,234 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 5,281 | 15,064 | +9,783 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 9,536 | +9,536 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 9,345 | +9,345 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 8,775 | +8,775 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 8,657 | +8,657 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,603 | 10,354 | +6,751 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 11,985 | 18,636 | +6,651 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 16,568 | 21,965 | +5,397 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,500,000 | 1,505,315 | +5,315 | 1.50 | 1.76 | +0.26 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 2,883 | 5,783 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 954 | 2,844 | +1,890 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 981 | 2,854 | +1,873 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 711 | 2,064 | +1,353 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 26,139 | 27,433 | +1,294 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 390 | 888 | +498 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 540 | 963 | +423 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 58 | 94 | +36 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 10 | 25 | +15 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 5 | 10 | +5 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.12 | 1.30 | +0.19 | hold |
| PERCEPTIVE ADVISORS LLC | 415,000 | 415,000 | 0 | 0.19 | 0.21 | +0.02 | hold |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.55 | 0.74 | +0.19 | hold |
| Arax Advisory Partners | 119 | 119 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 1.98 | 3.30 | +1.32 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 2.39 | 2.45 | +0.06 | hold |
| HHLR ADVISORS, LTD. | 4,484,672 | 4,484,672 | 0 | 2.05 | 2.31 | +0.26 | hold |
| Ghisallo Capital Management LLC | 50,000 | 50,000 | 0 | 0.08 | 0.06 | -0.02 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| STRS OHIO | 1,700 | 1,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 1,492 | 183 | -1,309 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 25,000 | 0 | -25,000 | 0.00 | 0.00 | -0.00 | sell |
| Hidden Lake Asset Management LP | 37,121 | 0 | -37,121 | 0.59 | 0.00 | -0.59 | sell |