| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 2,058,069 | 3,407,549 | +1,349,480 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,483,540 | 2,029,531 | +545,991 | 0.00 | 0.00 | +0.00 | buy |
| INFINITUM ASSET MANAGEMENT, LLC | 3,418,923 | 3,868,923 | +450,000 | 16.49 | 13.13 | -3.36 | buy |
| UBS Group AG | 86,588 | 497,601 | +411,013 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 101,354 | 392,022 | +290,668 | 0.00 | 0.00 | +0.00 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,412,788 | 3,703,452 | +290,664 | 2.80 | 2.07 | -0.73 | buy |
| STATE STREET CORP | 740,792 | 1,027,628 | +286,836 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 256,422 | +256,422 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,838,376 | 2,046,138 | +207,762 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 180,223 | +180,223 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 146,916 | 296,916 | +150,000 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 596,018 | 716,288 | +120,270 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 176,169 | 286,104 | +109,935 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 100,000 | +100,000 | 0.00 | 0.10 | +0.10 | buy |
| Anson Funds Management LP | 0 | 99,887 | +99,887 | 0.00 | 0.20 | +0.20 | buy |
| GOLDMAN SACHS GROUP INC | 339,196 | 431,939 | +92,743 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 91,718 | +91,718 | 0.00 | 0.00 | +0.00 | buy |
| Fund 1 Investments, LLC | 528,395 | 619,851 | +91,456 | 1.63 | 1.40 | -0.23 | buy |
| Novo Holdings A/S | 1,872,142 | 1,942,142 | +70,000 | 2.88 | 2.31 | -0.57 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 188,202 | 243,486 | +55,284 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 41,449 | +41,449 | 0.00 | 0.05 | +0.05 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,571 | 42,268 | +39,697 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 33,500 | +33,500 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,946,054 | 1,971,054 | +25,000 | 9.30 | 5.68 | -3.62 | buy |
| NORTHERN TRUST CORP | 206,755 | 231,167 | +24,412 | 0.00 | 0.00 | -0.00 | buy |
| Jump Financial, LLC | 0 | 20,400 | +20,400 | 0.00 | 0.01 | +0.01 | buy |
| Rafferty Asset Management, LLC | 15,749 | 34,361 | +18,612 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 9,454 | 27,768 | +18,314 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 17,794 | +17,794 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 66,329 | 81,746 | +15,417 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 30,747 | 45,977 | +15,230 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 14,158 | +14,158 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 117,212 | 129,935 | +12,723 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 33,300 | 43,800 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 27,473 | 36,942 | +9,469 | 0.00 | 0.00 | -0.00 | buy |
| Swiss National Bank | 26,400 | 35,500 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 45 | 7,454 | +7,409 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 7,000 | +7,000 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 13,022 | 18,561 | +5,539 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 58,778 | 63,283 | +4,505 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 35,580 | 39,235 | +3,655 | 0.51 | 0.45 | -0.06 | buy |
| WELLS FARGO & COMPANY/MN | 11,903 | 15,179 | +3,276 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 11,453 | 14,355 | +2,902 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 409 | 3,258 | +2,849 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 17,580 | 19,972 | +2,392 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 21 | 2,068 | +2,047 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 1,395 | +1,395 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 3,979 | 4,816 | +837 | 0.03 | 0.03 | -0.00 | buy |
| SIGNATUREFD, LLC | 18 | 368 | +350 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 306 | +306 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 288 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,322 | 1,568 | +246 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,871 | 7,111 | +240 | 0.01 | 0.01 | -0.00 | buy |
| US BANCORP \DE\ | 1,127 | 1,287 | +160 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 25 | 48 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 863 | 873 | +10 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 4 | 11 | +7 | 0.00 | 0.00 | 0.00 | buy |
| Sterling Capital Management LLC | 56 | 60 | +4 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.66 | 1.34 | -0.32 | hold |
| Ameritas Investment Partners, Inc. | 2,352 | 2,352 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 28,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 16 | 16 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.74 | 0.68 | -0.07 | hold |
| Daiwa Securities Group Inc. | 111 | 111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 17,110 | 17,110 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 2.51 | 1.92 | -0.59 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 0.76 | 0.91 | +0.15 | hold |
| IFP Advisors, Inc | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 82 | 82 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 37 | 37 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HHLR ADVISORS, LTD. | 4,484,672 | 4,484,672 | 0 | 3.14 | 2.02 | -1.12 | hold |
| Nuveen, LLC | 47,663 | 47,663 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 700,000 | 700,000 | 0 | 0.79 | 0.51 | -0.28 | hold |
| Police & Firemen's Retirement System of New Jersey | 6,255 | 6,255 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 14,790 | 14,790 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,783 | 7,783 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Clearstead Advisors, LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 20 | 20 | 0 | 0.00 | 0.00 | -0.00 | hold |
| COOPERMAN LEON G | 421,278 | 421,278 | 0 | 0.32 | 0.24 | -0.08 | hold |
| AMALGAMATED BANK | 963 | 963 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GAMMA Investing LLC | 99 | 85 | -14 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 334 | 313 | -21 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 15,049 | 15,016 | -33 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 123 | 24 | -99 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 33,954 | 33,803 | -151 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,403 | 13,246 | -157 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 459 | 281 | -178 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 376 | 190 | -186 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 14,409 | 13,991 | -418 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 14,336 | 11,823 | -2,513 | 0.00 | 0.00 | -0.00 | sell |
| WEXFORD CAPITAL LP | 5,519 | 1,567 | -3,952 | 0.03 | 0.01 | -0.02 | sell |
| Tower Research Capital LLC (TRC) | 6,669 | 1,283 | -5,386 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 8,730 | 0 | -8,730 | 0.04 | 0.00 | -0.04 | sell |
| Brevan Howard Capital Management LP | 9,592 | 0 | -9,592 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 47,585 | 36,136 | -11,449 | 0.01 | 0.01 | -0.00 | sell |
| CITIGROUP INC | 21,567 | 10,037 | -11,530 | 0.00 | 0.00 | -0.00 | sell |
| MOODY ALDRICH PARTNERS LLC | 71,575 | 59,454 | -12,121 | 0.30 | 0.21 | -0.09 | sell |