| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 1,845,162 | 2,246,000 | +400,838 | 1.56 | 2.22 | +0.66 | buy |
| STATE STREET CORP | 476,809 | 814,091 | +337,282 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,931,419 | 2,135,092 | +203,673 | 0.00 | 0.00 | +0.00 | buy |
| Hidden Lake Asset Management LP | 0 | 184,605 | +184,605 | 0.00 | 3.36 | +3.36 | buy |
| GOLDMAN SACHS GROUP INC | 72,968 | 207,269 | +134,301 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 1,976,387 | 2,059,387 | +83,000 | 7.44 | 9.33 | +1.90 | buy |
| VANGUARD GROUP INC | 1,345,550 | 1,417,291 | +71,741 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 18,636 | 72,693 | +54,057 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 41,921 | +41,921 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 26,400 | +26,400 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 120,944 | 145,797 | +24,853 | 0.02 | 0.03 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 17,836 | +17,836 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 9,536 | 27,299 | +17,763 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 15,339 | +15,339 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 1,505,315 | 1,520,627 | +15,312 | 1.76 | 2.45 | +0.70 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 14,798 | +14,798 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 20,400 | 34,121 | +13,721 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 41,522 | 53,499 | +11,977 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,064 | 13,649 | +11,585 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,844 | 13,627 | +10,783 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 230,511 | 241,009 | +10,498 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 9,532 | +9,532 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,331 | 24,136 | +8,805 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 8,373 | +8,373 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 8,165 | +8,165 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 7,145 | +7,145 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 10,354 | 14,493 | +4,139 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 202,368 | 206,379 | +4,011 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 12,445 | 15,685 | +3,240 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 33,621 | 36,690 | +3,069 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 2,747 | +2,747 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 43,265 | 45,544 | +2,279 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,783 | 7,783 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 9,345 | 10,965 | +1,620 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 183 | 1,599 | +1,416 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,787 | 17,114 | +1,327 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,123 | +1,123 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 16,350 | 17,460 | +1,110 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 44 | 555 | +511 | 0.00 | 0.01 | +0.01 | buy |
| Sterling Capital Management LLC | 59 | 373 | +314 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,657 | 8,868 | +211 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 888 | 996 | +108 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 27 | 96 | +69 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 25 | 70 | +45 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 45 | +35 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 94 | 107 | +13 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,027,328 | 3,027,328 | 0 | 1.30 | 1.67 | +0.37 | hold |
| Ameritas Investment Partners, Inc. | 2,854 | 2,854 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 28,200 | 28,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HSG Holding Ltd | 663,308 | 663,308 | 0 | 0.74 | 0.69 | -0.04 | hold |
| Cormorant Asset Management, LP | 585,462 | 585,462 | 0 | 0.73 | 0.86 | +0.13 | hold |
| Arax Advisory Partners | 119 | 119 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sofinnova Investments, Inc. | 1,696,752 | 1,696,752 | 0 | 3.30 | 3.31 | +0.01 | hold |
| General Catalyst Group Management, LLC | 1,494,786 | 1,494,786 | 0 | 2.45 | 3.49 | +1.04 | hold |
| HHLR ADVISORS, LTD. | 4,484,672 | 4,484,672 | 0 | 2.31 | 4.14 | +1.82 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 963 | 963 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Blue Trust, Inc. | 39 | 0 | -39 | 0.00 | 0.00 | -0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 67 | 0 | -67 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 11,927 | 11,807 | -120 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 27,433 | 27,252 | -181 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,234 | 10,018 | -216 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 68,321 | 68,003 | -318 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 597,165 | 596,182 | -983 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 15,064 | 14,007 | -1,057 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 1,700 | 0 | -1,700 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 8,775 | 0 | -8,775 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 11,354 | 0 | -11,354 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 2,119,695 | 2,101,037 | -18,658 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 21,965 | 3,300 | -18,665 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 167,734 | 148,584 | -19,150 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 47,266 | 0 | -47,266 | 0.40 | 0.00 | -0.40 | sell |
| Ghisallo Capital Management LLC | 50,000 | 0 | -50,000 | 0.06 | 0.00 | -0.06 | sell |
| MARSHALL WACE, LLP | 85,250 | 0 | -85,250 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 216,630 | 52,545 | -164,085 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 415,000 | 0 | -415,000 | 0.21 | 0.00 | -0.21 | sell |